Scopolamine Effects Under a Titrating-Delayed-Nonmatching-to-Position Procedure

Porritt, Matthew; Poling, Alan

doi:10.1007/bf03395601

Cited by 5 publications

(8 citation statements)

References 21 publications

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“…Indeed, the terminal retention intervals in our study are substantially longer than those produced by comparable procedures in animals given fewer sessions [41], [46], [47]. Thus, the TDMTP procedure used here might be a good choice for future studies evaluating the effects of working-memory training on subsequent delay discounting in rats.…”

Section: Discussionmentioning

confidence: 76%

Impulsive Choice Predicts Poor Working Memory in Male Rats

2014

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A number of maladaptive behaviors and poor health outcomes (e.g., substance abuse, obesity) correlate with impulsive choice, which describes the tendency to prefer smaller, immediate rewards in lieu of larger, delayed rewards. Working memory deficits are often reported in those diagnosed with the same maladaptive behaviors. Human studies suggest that impulsive choice is associated with working memory ability but, to date, only one study has explored the association between working memory and impulsive choice in rats and no relation was reported. The current study reevaluated the association between working memory and impulsive choice in 19 male Long-Evans rats. Psychophysical adjusting procedures were used to quantify working memory (titrating-delay match-to-position procedure) and impulsive choice (adjusting delay procedure). Rats were partitioned into low- and high-impulsive groups based on performance in the impulsive choice task. Low-impulsive rats performed significantly better in the working memory assessment. Across all rats, impulsive choice was negatively correlated with working memory performance. These findings support the hypothesis that prefrontal cortex function, specifically, working memory, is related to impulsive choice. Future research might profitably examine the experimental variables designed to influence working memory to evaluate the effects of these variables on impulsive choice and maladaptive behaviors with which it is correlated.

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Section: Discussionmentioning

confidence: 76%

Impulsive Choice Predicts Poor Working Memory in Male Rats

2014

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“…First, it is possible that the working-memory ability of the WMT rats did not improve (relative to the Sham-trained rats) by the working-memory training that was provided. One piece of evidence against this is the posttraining retention intervals across which our rats remembered the sample stimulus are, to the best or our knowledge, the highest reported in the titrating-delay match-to-position literature (e.g., Porritt & Poling, 2008, using a similar procedure, reported a mean peak retention interval of 32.85 s, SEM = 4.56, whereas our WMT rats achieved a mean peak retention interval of 68.32 s, SEM = 5.71, in the posttraining reassessment of working memory). More robust evidence that WMT positively impacted working-memory ability would have been obtained had WMT rats performed better than Sham rats in a novel working-memory task (for review of rodent working-memory preparations, see Dudchenko, 2004; Pontecorvo, Sahgal, & Steckler, 1996) and future studies might include such a posttraining test phase.…”

Section: Discussionmentioning

confidence: 94%

“…Working-memory training (WMT). Rats assigned to the WMT group completed 140 WMT sessions in which they earned food by making correct choices in a modified TDMTP task (see, e.g., Kangas et al, 2010;Porritt & Poling, 2008). In this procedure, rats were required to remember a cue over a delay period (i.e., retention interval) in which the cue was absent.…”

Section: Apparatusmentioning

confidence: 99%

“…One rat from each pair was randomly assigned to the WMT group; the other rat was assigned to the Sham-training group. WMT was a variation of the titrating-delay match-to-position (TDMTP) task, a commonly used operant preparation to assess working memory in nonhumans (see, Kangas, Vaidya, & Branch, 2010; Porritt & Poling, 2008). We selected this task for two reasons.…”

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confidence: 99%

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Working‐memory training: Effects on delay discounting in male long evans rats

Renda

Stein

Madden

2014

J Exper Analysis Behavior

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Delay discounting describes the devaluation of a reward as the delay to the receipt of the reward increases. Because steep delay discounting is robustly correlated with a number of behavioral problems (e.g., substance dependence, gambling) and some evidence suggests steep discounting precedes and predicts drug-taking in humans and rats, this study sought to experimentally reduce rats' delay discounting. Human stimulant-dependent participants given working-memory training reportedly decreased their rates of discounting relative to a sham-training group (Bickel, Yi, Landes, Hill, & Baxter, 2011). To evaluate the cross-species generality of this effect, 38 male Long-Evans rats, matched on pretraining delay-discounting rates, were randomly assigned to receive 140 sessions of working-memory training or sham training (which required no memory of the sample stimulus). Large between-group differences in working memory were observed after training; however, posttraining delay-discounting rates were undifferentiated across groups. Potential explanations for these findings are discussed.

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“…Relações de identidade de cor ou forma, ou seja, a escolha definida como correta é a do estímulo de comparação com cor ou forma igual a do modelo, foram requeridas em 13 dos 21 experimentos. Dois estudos (Porritt & Poling, 2008;Robinson, Scheff, Pierre-Louis, & Han, 2000) utilizaram tarefas de escolha da posição diferente (oddity ou non matching) e três o MTS arbitrário. Neste último, o modelo e o estímulo de comparação correspondente não apresentam semelhança física; a relação é definida pelo experimentador (e.g., uma forma abstrata e um som).…”

Section: Tipos De Discriminações Condicionaisunclassified

Pareamento Ao Modelo Com Ajuste Do Atraso: Uma Revisão Da Literatura

Albrecht¹,

Hanna²

2019

REBAC

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O Pareamento-ao-Modelo com Ajuste do Atraso (TDMTS) é utilizado para estudar memória de trabalho e fenômenos correlatos. Neste procedimento, a escolha do estímulo correspondente ao modelo deve ocorrer após um intervalo de tempo desde a retirada do modelo (atraso). O atraso é ajustado a partir dos acertos e erros do participante. O objetivo deste artigo foi fazer uma revisão de literatura de estudos que manipularam variáveis metodológicas do TDMTS. A partir de buscas em bancos de dados, na internet e nas referências dos artigos encontrados, foram analisados 16 artigos, que descrevem 21 experimentos, publicados de 1965 a 2019. A revisão mostrou os critérios e valores de parâmetros mais utilizados na literatura, e resumiu os efeitos da manipulação de aspectos metodológicos. Atrasos ajustados mais longos estão relacionados ao: aumento da observação ao modelo, programação do atraso inicial de cada sessão baseada nos atrasos finais da sessão anterior; critério de ajuste mais tolerante; maiores valores do incremento; e programação de reforços diferenciais para cada discriminação. Estes resultados carecem de replicações controladas para avaliar a generalidade, considerando a variedade de parâmetros, critérios e sujeitos experimentais.Palavras-chave: discriminação condicional, memória de trabalho, pareamento-ao-modelo com atraso, ajuste do atraso, revisão.

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Scopolamine Effects Under a Titrating-Delayed-Nonmatching-to-Position Procedure

Abstract: In a study of working memory, the performance of rats under titrating-delayednonmatching-to-position (TDNMTP)

Cited by 5 publications

References 21 publications

Impulsive Choice Predicts Poor Working Memory in Male Rats

Impulsive Choice Predicts Poor Working Memory in Male Rats

Working‐memory training: Effects on delay discounting in male long evans rats

Pareamento Ao Modelo Com Ajuste Do Atraso: Uma Revisão Da Literatura

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