Scorbutic and fasted guinea pig sera contain an insulin-like growth factor I-reversible inhibitor of proteoglycan and collagen synthesis in chick embryo chondrocytes and adult human skin fibroblasts

Dietary Protein as a Potent Regulator of the Hyaluronan Synthase Gene in Rat Skin

“…[34][35][36][37] We and others have shown that protein malnutrition reduced IGF-I and W or increased IGFBP-1 in the circulation. 15,[35][36][37] These results suggest that alterations in the components of the IGF system may play a part in the reduction of hyaluronan under protein malnutrition. Further studies, using transgenic and knockout models, would help determine the role of the IGF system in the regulation of hyaluronan gene expression by protein nutrition.…”

Effects of Protein Deprivation on α1(I) and α1(III) Collagen and Its Degrading System in Rat Skin

“…10,[31][32][33] Elevated circulating levels of these IGFBPs under these conditions seem to block the action of insulin-like growth factor-I (IGF-I) which is essential for maintaining the expression of collagen genes. We and others have shown that protein malnutrition reduced IGF-I and increased IGFBP-1 in the circulation.…”

Administration of Ascorbic Acid and an Aldose Reductase Inhibitor (Tolrestat) in Diabetes: Effect on Urinary Albumin Excretion

“…AA is an important anti-oxidant, and this is particularly relevant in this context, as diabetes has been shown to be a state of increased oxidative stress which can affect endothelial cell function [6, 7]. Tissue culture experiments, involving a number of human and animal cell types, have also shown that deposition of matrix collagen, glycoproteins, and proteoglycans (PG) is enhanced by AA [8, 9, 10, 11, 12]. In addition, we have previously shown that AA affects PG of rat mesangial matrix qualitatively, by increasing its degree of sulphation [13].…”