<scp>3D</scp>‐printed hydroxyapatite scaffolds for bone tissue engineering: A systematic review in experimental animal studies

Avanzi, Ingrid Regina; Parisi, Júlia Risso; Souza, Amanda de; Cruz, Matheus Almeida; Martignago, Cintia Cristina Santi; Ribeiro, Daniel Araki; Braga, Anna Rafaela Cavalcante; Rennó, Ana Cláudia Muniz

doi:10.1002/jbm.b.35134

Cited by 22 publications

(13 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…FDM scaffolds showed favorable mechanical and biochemical properties in the bone regeneration process. The performance of PCL scaffolds in the compression and biocompatibility module has also been demonstrated [ 153 ]. On the other hand, PLA scaffolds with different pore sizes showed the appropriate mechanical properties and the distribution of bone marrow stromal cells.…”

Section: Three-dimensional Printing and Computer-aided Designmentioning

confidence: 99%

Application of 3D Printing in Bone Grafts

Brachet

Belzek

Furtak

et al. 2023

Cells

View full text Add to dashboard Cite

The application of 3D printing in bone grafts is gaining in importance and is becoming more and more popular. The choice of the method has a direct impact on the preparation of the patient for surgery, the probability of rejection of the transplant, and many other complications. The aim of the article is to discuss methods of bone grafting and to compare these methods. This review of literature is based on a selective literature search of the PubMed and Web of Science databases from 2001 to 2022 using the search terms “bone graft”, “bone transplant”, and “3D printing”. In addition, we also reviewed non-medical literature related to materials used for 3D printing. There are several methods of bone grafting, such as a demineralized bone matrix, cancellous allograft, nonvascular cortical allograft, osteoarticular allograft, osteochondral allograft, vascularized allograft, and an autogenic transplant using a bone substitute. Currently, autogenous grafting, which involves removing the patient’s bone from an area of low aesthetic importance, is referred to as the gold standard. 3D printing enables using a variety of materials. 3D technology is being applied to bone tissue engineering much more often. It allows for the treatment of bone defects thanks to the creation of a porous scaffold with adequate mechanical strength and favorable macro- and microstructures. Bone tissue engineering is an innovative approach that can be used to repair multiple bone defects in the process of transplantation. In this process, biomaterials are a very important factor in supporting regenerative cells and the regeneration of tissue. We have years of research ahead of us; however, it is certain that 3D printing is the future of transplant medicine.

show abstract

Section: Three-dimensional Printing and Computer-aided Designmentioning

confidence: 99%

Application of 3D Printing in Bone Grafts

Brachet

Belzek

Furtak

et al. 2023

Cells

View full text Add to dashboard Cite

show abstract

“…Three-dimensional printing of gelatinbased hydrogels 92,93 for bone and cartilage applications was reported as were printed PEEK hip stems 94 and hydroxyapatite-based biomaterials. 95 Many other topics were covered in JBMR B in the past year and no review can possibly cover all that was accomplished. I encourage you to review the work published in 2022 in JBMR B.…”

Section: Biomaterials Research In Advanced Materials (Ekaterina Peret...mentioning

confidence: 99%

“…These works have investigated the range of 3D printing from electron‐beam printing of titanium‐based spinal cages 91 to 3D printing of Hydroxyapatite and/or polymeric hydrogel biomaterials. Three‐dimensional printing of gelatin‐based hydrogels 92,93 for bone and cartilage applications was reported as were printed PEEK hip stems 94 and hydroxyapatite‐based biomaterials 95 …”

Section: Journal Of Biomedical Materials Research Part B: Applied Bio...mentioning

confidence: 99%

The Year 2022 in biomaterials research: A perspective from the editors of six leading journals

Stegemann

Wagner

Göbel

et al. 2023

J Biomedical Materials Res

View full text Add to dashboard Cite

The field of biomaterials science is highly active, with a steadily increasing number of publications and new journals being founded. This article brings together contributions from the editors of six leading journals in the area of biomaterials science and engineering. Each contributor highlights specific advances, topics, and trends that have emerged through the publications in their respective journal in the calendar year 2022. It presents a global perspective on a wide range of material types, functionalities, and applications. The highlighted topics include a diversity of biomaterials; from proteins, polysaccharides, and lipids to ceramics, metals, advanced composites, and a variety of new forms of these materials. Important advances in dynamically functional materials are presented, including a range of fabrication techniques such as bioassembly, 3D bioprinting and microgel formation. Similarly, several applications are highlighted in drug and gene delivery, biological sensing, cell guidance, immunoengineering, electroconductivity, wound healing, infection resistance, tissue engineering, and treatment of cancer. The goal of this paper is to provide the reader with both a broad view of recent biomaterials research, as well as expert commentary on some of the key advances that will shape the future of biomaterials science and engineering.

show abstract

“…39 The solubility, bioactivity, and biological response of HAp can be modified by anionic and cationic substitution. For these reasons, HAp is widely used for preparing polymer-ceramic composite materials 41,42 to impart bioactivity and osteoconductivity and improve mechanical properties. 43 Kokubo and Takadama 44 proposed that HAp formation in vitro can be produced using a simulated body fluid (SBF) with ion concentrations practically equal to those of human blood plasma.…”

Section: Introductionmentioning

confidence: 99%

Biomimetic Growth of Hydroxyapatite in Hybrid Polycaprolactone/Graphene Oxide Ultra-Porous Scaffolds

et al. 2023

View full text Add to dashboard Cite

This paper reports the preparation and characterization of hybrid scaffolds composed of polycaprolactone (PCL) and different graphene oxide (GO) amounts, intending to incorporate the intrinsic characteristics of their constituents, such as bioactivity and biocidal effect. These materials were fabricated by a solvent-casting/particulate leaching technique showing a bimodal porosity (macro and micro) that was around 90%. The highly interconnected scaffolds were immersed in a simulated body fluid, promoting the growth of a hydroxyapatite (HAp) layer, making them ideal candidates for bone tissue engineering. The growth kinetics of the HAp layer was influenced by the GO content, a remarkable result. Furthermore, as expected, the addition of GO neither significantly improves nor reduces the compressive modulus of PCL scaffolds. The thermal behavior of composites was investigated by differential scanning calorimetry, showing an increase in crystallinity as the addition of GO raised, which implies that GO nanosheets can act as seeds to induce the crystallization of PCL. The improved bioactivity was demonstrated by the deposition of an HAp layer on the surface of the scaffold with GO, especially with a 0.1% GO content.

show abstract

3D‐printed hydroxyapatite scaffolds for bone tissue engineering: A systematic review in experimental animal studies

Cited by 22 publications

References 59 publications

Application of 3D Printing in Bone Grafts

Application of 3D Printing in Bone Grafts

The Year 2022 in biomaterials research: A perspective from the editors of six leading journals

Biomimetic Growth of Hydroxyapatite in Hybrid Polycaprolactone/Graphene Oxide Ultra-Porous Scaffolds

Contact Info

Product

Resources

About