2018
DOI: 10.15252/embr.201846303
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ADAR 1‐mediated RNA editing is required for thymic self‐tolerance and inhibition of autoimmunity

Abstract: T cells play a crucial role in the adaptive immune system, and their maturation process is tightly regulated. Adenosine deaminase acting on RNA 1 (ADAR1) is the enzyme responsible for adenosine‐to‐inosine RNA editing in dsRNAs, and loss of ADAR1 activates the innate immune sensing response via melanoma differentiation‐associated protein 5 (MDA5), which interprets unedited dsRNA as non‐self. Although ADAR1 is highly expressed in the thymus, its role in the adaptive immune system, especially in T cells, remains … Show more

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Cited by 54 publications
(78 citation statements)
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“…Remarkably, excessive ISG expression in T cells, impaired thymic T cell maturation, and spontaneous colitis could all be rescued by deleting MDA5 in the CD4 cre ADAR1 flox/flox mice. Altogether, these findings demonstrate that ADAR1 is required for thymic T cell tolerance, which is important for preventing autoimmune diseases such as colitis .…”
Section: Adar1 Is Required For Thymic T Cell Maturation and Intestinamentioning
confidence: 73%
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“…Remarkably, excessive ISG expression in T cells, impaired thymic T cell maturation, and spontaneous colitis could all be rescued by deleting MDA5 in the CD4 cre ADAR1 flox/flox mice. Altogether, these findings demonstrate that ADAR1 is required for thymic T cell tolerance, which is important for preventing autoimmune diseases such as colitis .…”
Section: Adar1 Is Required For Thymic T Cell Maturation and Intestinamentioning
confidence: 73%
“…First, these findings suggest that moderate (or low) ISG expression may play an active role in thymic T cell maturation. The authors clearly show that ISG expression is significantly elevated at the 4SP stage . In the absence of ADAR1, however, ISG expression becomes dysregulated leading to excessive ISG expression and defective T cell maturation.…”
Section: Adar1 Is Required For Thymic T Cell Maturation and Intestinamentioning
confidence: 95%
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