AgI‐promoted one‐pot synthesis of aminoindolizines via sequential Mannich‐Grignard addition and intramolecular cyclization in water

Abstract

The efficient synthesis of aminoindolizines in ecofriendly water with broad substrate scope from the mild and readily available AgI‐catalyzed one‐pot three‐component reaction of pyridine‐2‐carboxaldehyde, secondary amines, and terminal alkynes proceeds through the sequential Mannich‐Grignard addition as well as intramolecular cyclization was reported for the first time.

An Overview of Silver‐Catalyzed Mannich Reactions

“…Using a similar approach (Mannich-Grignard followed by cyclization), Vadde and team could synthesize a range of aminoindolizines using silver catalysis. [55] In this context, secondary amines reacted with 2-formylpyridine and various alkynes under the conditions of-2 mol% AgI in green solventwater at 70 °C for 15-15.5 h under nitrogen atmosphere (Scheme 35). Here, dibenzylamines and aliphatic amines (cyclic) rendered higher yields of products in comparison to acyclic amines.…”