<scp>B</scp>asal ganglia structure in Tourette's disorder and/or attention‐deficit/hyperactivity disorder

Forde, Natalie J.; Zwiers, Marcel P.; Naaijen, Jilly; Akkermans, Sophie E.A.; Openneer, Thaïra J.C.; Visscher, Frank; Dietrich, Andrea; Buitelaar, Jan K.; Hoekstra, Pieter J.

doi:10.1002/mds.26849

Cited by 17 publications

(10 citation statements)

References 38 publications

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“…One apparently robust result, described best in a relatively large prospective study by Peterson and colleagues (Peterson et al, 2003;Bloch et al, 2005), is decreased caudate nucleus volume. Recent, relatively large morphometry studies in Tourette syndrome and control children, however, did not identify changes in caudate or putamen volumes in Tourette syndrome subjects (Greene et al, 2017;Forde et al, 2017). Greene et al (2017) identified only volume changes in the thalamus, hypothalamus, and midbrain.…”

Section: Imaging Resultsmentioning

confidence: 90%

Tourette syndrome: a disorder of the social decision-making network

Albin

2017

Brain

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Tourette syndrome is a common neurodevelopmental disorder defined by characteristic involuntary movements, tics, with both motor and phonic components. Tourette syndrome is usually conceptualized as a basal ganglia disorder, with an emphasis on striatal dysfunction. While considerable evidence is consistent with these concepts, imaging data suggest diffuse functional and structural abnormalities in Tourette syndrome brain. Tourette syndrome exhibits features that are difficult to explain solely based on basal ganglia circuit dysfunctions. These features include the natural history of tic expression, with typical onset of tics around ages 5 to 7 years and exacerbation during the peri-pubertal years, marked sex disparity with higher male prevalence, and the characteristic distribution of tics. The latter are usually repetitive, somewhat stereotyped involuntary eye, facial and head movements, and phonations. A major functional role of eye, face, and head movements is social signalling. Prior work in social neuroscience identified a phylogenetically conserved network of sexually dimorphic subcortical nuclei, the Social Behaviour Network, mediating many social behaviours. Social behaviour network function is modulated developmentally by gonadal steroids and social behaviour network outputs are stereotyped sex and species specific behaviours. In 2011 O'Connell and Hofmann proposed that the social behaviour network interdigitates with the basal ganglia to form a greater network, the social decision-making network. The social decision-making network may have two functionally complementary limbs: the basal ganglia component responsible for evaluation of socially relevant stimuli and actions with the social behaviour network component responsible for the performance of social acts. Social decision-making network dysfunction can explain major features of the neurobiology of Tourette syndrome. Tourette syndrome may be a disorder of social communication resulting from developmental abnormalities at several levels of the social decision-making network. The social decision-making network dysfunction hypothesis suggests new avenues for research in Tourette syndrome and new potential therapeutic targets.

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Section: Imaging Resultsmentioning

confidence: 90%

Tourette syndrome: a disorder of the social decision-making network

Albin

2017

Brain

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“…The present functional magnetic resonance imaging (fMRI) study aimed to increase this understanding by investigating neural reward processing in children with TS and/or ADHD and healthy controls. Of this sample, basal ganglia structure, glutamate levels, and anterior cingulate cortex cytoarchitecture have been reported previously (Forde et al, 2018(Forde et al, , 2017Naaijen et al, 2017).…”

Section: Introductionmentioning

confidence: 76%

“…The shape of the neurodevelopmental trajectory may be different in patients compared to controls, and persistent cases may present with stronger abnormalities (Debes et al, 2015). Notably, structural abnormalities in basal ganglia are more apparent in older TS samples (Forde et al, 2017). Discrepancies could also be due to variations in paradigms used.…”

Section: Discussionmentioning

confidence: 99%

Neural reward processing in paediatric Tourette syndrome and/or attention-deficit/hyperactivity disorder

Akkermans

Rooij²,

Naaijen³

et al. 2019

Psychiatry Research: Neuroimaging

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“…Previous in vivo MRI studies of basal ganglia volume and shape in TS have produced differing results (reviewed in Greene et al (2017) ). A study of 47 children age 8-12 with TS, and controls with or without ADHD, found no significant group differences ( Forde et al , 2017 ).…”

Section: Resultsmentioning

confidence: 99%

Tourette syndrome research highlights from 2017

2018

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This is the fourth yearly article in the Tourette Syndrome Research Highlights series, summarizing research from 2017 relevant to Tourette syndrome and other tic disorders. The authors briefly summarize reports they consider most important or interesting. The highlights from 2018 article is being drafted on the Authorea online authoring platform, and readers are encouraged to add references or give feedback on our selections using the comments feature on that page. After the calendar year ends, the article is submitted as the annual update for the Tics collection on F1000Research.

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Basal ganglia structure in Tourette's disorder and/or attention‐deficit/hyperactivity disorder

Abstract: We found no evidence that Tourette's disorder, attention-deficit/hyperactivity disorder severity, or a combination thereof are associated with structural variation of the basal ganglia in 8- to 12-year-old patients. © 2016 International Parkinson and Movement Disorder Society.

Cited by 17 publications

References 38 publications

Tourette syndrome: a disorder of the social decision-making network

Tourette syndrome: a disorder of the social decision-making network

Neural reward processing in paediatric Tourette syndrome and/or attention-deficit/hyperactivity disorder

Tourette syndrome research highlights from 2017

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