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            8 resident memory T cells with interleukin 17A‐producing potential are accumulated in disease‐naïve nonlesional sites of psoriasis possibly in correlation with disease duration

Vo, Sa; Watanabe, Rei; Koguchi‐Yoshioka, Hanako; Matsumura, Yutaka; Ishitsuka, Yosuke; Nakamura, Yoshiyuki; Fujisawa, Yasuhiro; Fujimoto, Manabu

doi:10.1111/bjd.17748

Cited by 55 publications

(58 citation statements)

References 8 publications

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“…In contrast, in the dermis of the psoriatic plaques, TRM cells show lower expression of CD103, as demonstrated by Cheuk et al [5]. In the first stage of psoriatic inflammation, in the skin without lesions yet, epidermal TRM cells expressing CCR6 cooperate with CCL20 expressing keratinocytes [35,36].…”

Section: Tissue Resident Memory Cells In Psoriasismentioning

confidence: 90%

“…Immunofluorescence study showed that CD103+ CD8 TRM, both in non-lesional and lesional were dominant in the epidermis compared to the skin of healthy volunteers. In addition, IL-17A production was higher in patients with longer disease duration [36].…”

Section: Tissue Resident Memory Cells In Psoriasismentioning

confidence: 90%

“…In turn, Vo et al [36] evaluated the phenotypic features of TRM in non-lesional, lesional psoriasis and healthy skin. Immunofluorescence study showed that CD103+ CD8 TRM, both in non-lesional and lesional were dominant in the epidermis compared to the skin of healthy volunteers.…”

Section: Tissue Resident Memory Cells In Psoriasismentioning

confidence: 99%

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Immunological Memory of Psoriatic Lesions

Owczarczyk‐Saczonek

Krajewska–Włodarczyk

Kasprowicz-Furmańczyk

et al. 2020

IJMS

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The natural course of psoriasis is the appearance of new lesions in the place of previous ones, which disappeared after a successful therapy. Recent studies of psoriasis etiopathogenesis showed that after psoriatic plaques have disappeared, in healthy skin we can still find a trace of inflammation in the form of tissue resident memory cells (TRM). They are originally responsible for protection against viral and bacterial infections in non-lymphatic tissues. In psoriatic inflammation, they are characterized by heterogeneity depending on their origin. CD8+ T cells TRM are abundantly present in psoriatic epidermis, while CD4+ TRM preferentially populate the dermis. In psoriasis, epidermal CD8+ TRM cells express CLA, CCR6, CD103 and IL-23R antigen and produce IL-17A during ex vivo stimulation. However, CD4+ CD103+ TRM can also colonize the epidermis and produce IL-22 during stimulation. Besides T cells, Th22 and epidermal DCs proved that epidermal cells in healed skin were still present and functioning after several years of disease remission. It explains the clinical phenomenon of the tendency of psoriatic lesions to relapse in the same location and it allows to develop new therapeutic strategies in the future.

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Section: Tissue Resident Memory Cells In Psoriasismentioning

confidence: 90%

Section: Tissue Resident Memory Cells In Psoriasismentioning

confidence: 90%

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Immunological Memory of Psoriatic Lesions

Owczarczyk‐Saczonek

Krajewska–Włodarczyk

Kasprowicz-Furmańczyk

et al. 2020

IJMS

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“…Previous studies have characterized the phenotypical features of Trm cells in non-lesional, lesional and healthy psoriasis [ 24 ] and demonstrated the cytotoxic function of CD49a + Trm in human skin [ 9 ]. Studies have also shown that Trm cells in psoriatic patients had specific properties not found in Trm cells of healthy skin, suggesting that lasting control of psoriasis disease may require suppression of Trm cells [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Immunological Memory in Imiquimod-Induced Murine Model of Psoriasiform Dermatitis

Fenix

Wijesundara

Cowin

et al. 2020

IJMS

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Psoriasis is a common chronic inflammatory skin condition manifested by T cell responses and characterized by preferential recurrence at previously inflamed sites upon withdrawal of treatment. The site-specific disease memory in psoriasis has been linked to CD8+CD103+ tissue-resident memory T cells (Trm) in the epidermis which were previously thought to only provide “frontline” protection against pathogens and immunosurveillance during cancer development. In this study, we correlated the presence of a subset of the Trm cells which are also CD49a+ with disease severity in human psoriatic lesions with acute and chronic disease. Using an imiquimod (IMQ)-induced murine model of psoriasiform dermatitis, we also investigated the level of CD49a+ Trm cells in acute, chronic and resolved psoriatic lesions. Investigation of clinical human samples showed that patient disease severity highly correlated with the numbers of epidermal CD49a+ Trm cells. Additionally, this subset of Trm cells was shown to persist in resolved lesions of murine psoriasiform dermatitis once clinical disease features had subsided. Importantly, these CD49a+ Trm cells showed significantly higher levels of granzyme B (GzmB) production compared to acute disease, suggesting a potential role of CD49a+ Trm cells for psoriatic re-occurrence in resolved patients. Better understanding of epidermal CD49a+ Trm cell activity is necessary for development of advanced treatment strategies for psoriasis to permit long-term, continuous disease control.

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“…Actually, psoriatic neverlesional epidermis is enriched with CD103 + CD8 T RM with the potential of producing IL-17A. In mild psoriasis, relative IL-17A generation from CD103 + CD8 T RM compared to IFNg expression correlated with disease duration [34]. These observations on CD8 T RM in psoriasis imply that the population of CD8 T RM with an IL-17A-producing profile is constructed in psoriatic skin before disease formation in response to recruiting signals such as CCL20 and ICAM-1 and cytokines such as IL-23 and IL-15 and contributes to future lesion formation (Fig.…”

Section: Psoriasismentioning

confidence: 99%

Protective and pathogenic roles of resident memory T cells in human skin disorders

Watanabe

2019

Journal of Dermatological Science

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A B S T R A C TThe human skin is populated by recirculating T cells and skin-sessile resident memory T cells (T RM ). Skin T RM are constructed during immune responses against antigens that the host immune system encounters in the skin. T RM persist in the same sites for a long time and play important protective roles in skin immune responses in collaboration with other skin-composing cells such as dendritic cells and keratinocytes. These T RM with strong effector functions possibly also engender skin inflammatory disorders. Since human skin T cells, especially T RM , are phenotypically distinct from T cells in the blood circulation, T cells residing in the skin should be directly investigated, without presuming from the activities of blood T cells, in order to understand the functional characteristics of skin T cells in skin disorders. This review summarizes the features of human skin T RM and reviews the immunopathological involvement of T RM in human skin disorders such as infectious disease, inflammatory skin disease, and malignant skin tumors.

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CD 8 resident memory T cells with interleukin 17A‐producing potential are accumulated in disease‐naïve nonlesional sites of psoriasis possibly in correlation with disease duration

Cited by 55 publications

References 8 publications

Immunological Memory of Psoriatic Lesions

Immunological Memory of Psoriatic Lesions

Immunological Memory in Imiquimod-Induced Murine Model of Psoriasiform Dermatitis

Protective and pathogenic roles of resident memory T cells in human skin disorders

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