2023
DOI: 10.1111/pim.12979
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CD193 (CCR3) expression by B cells correlates with reduced IgE production in paediatric schistosomiasis

Abstract: We demonstrate that CD193, the eotaxin receptor, is highly expressed on circulating B cells in paediatric schistosomiasis mansoni. CD193 plays a role in directing granulocytes into sites of allergic-like inflammation in the mucosa, but little is known about its functional significance on human B cells. We sought to characterize CD193 expression and its relationship with S. mansoni infection. We found that CD193+ B cells increased with the intensity of schistosome infection. In addition, a significant negative … Show more

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