<scp>d</scp>‐Pinitol promotes tau dephosphorylation through a cyclin‐dependent kinase 5 regulation mechanism: A new potential approach for tauopathies?

Medina-Vera, Dina; Navarro, Juan Antonio Micó; Rivera, Patricia; Rosell‐Valle, Cristina; Gutiérrez‐Adán, Alfonso; Sanjuan, Carlos; López-Gambero, Antonio Jesús; Tovar, Rubén; Suárez, Juan; Pavón-Morón, Francisco Javier; Baixerás, Elena; Decara, Juan; Fonseca, Fernando Rodrı́guez de

doi:10.1111/bph.15907

Cited by 13 publications

(7 citation statements)

References 65 publications

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“…However, the presence of fructose demands more studies to clarify the potential unwanted side effects derived of the repeated consumption of carob syrup. The additional preclinical studies designed have addressed most of these potential problems, as well as added more information regarding the recently described properties of D-Pinitol [25,41,42].…”

Section: Discussionmentioning

confidence: 99%

Endocrine and Metabolic Impact of Oral Ingestion of a Carob-Pod-Derived Natural-Syrup-Containing D-Pinitol: Potential Use as a Novel Sweetener in Diabetes

et al. 2022

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The widespread use of added sugars or non-nutritive sweeteners in processed foods is a challenge for addressing the therapeutics of obesity and diabetes. Both types of sweeteners generate health problems, and both are being blamed for multiple complications associated with these prevalent diseases. As an example, fructose is proven to contribute to obesity and liver steatosis, while non-nutritive sweeteners generate gut dysbiosis that complicates the metabolic control exerted by the liver. The present work explores an alternative approach for sweetening through the use of a simple carob-pod-derived syrup. This sweetener consists of a balanced mixture of fructose (47%) and glucose (45%), as sweetening sugars, and a functional natural ingredient (D-Pinitol) at a concentration (3%) capable of producing active metabolic effects. The administration of this syrup to healthy volunteers (50 g of total carbohydrates) resulted in less persistent glucose excursions, a lower insulin response to the hyperglycemia produced by its ingestion, and an enhanced glucagon/insulin ratio, compared to that observed after the ingestion of 50 g of glucose. Daily administration of the syrup to Wistar rats for 10 days lowered fat depots in the liver, reduced liver glycogen, promoted fat oxidation, and was devoid of toxic effects. In addition, this repeated administration of the syrup improved glucose handling after a glucose (2 g/kg) load. Overall, this alternative functional sweetener retains the natural palatability of a glucose/fructose syrup while displaying beneficial metabolic effects that might serve to protect against the progression towards complicated obesity, especially the development of liver steatosis.

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Section: Discussionmentioning

confidence: 99%

Endocrine and Metabolic Impact of Oral Ingestion of a Carob-Pod-Derived Natural-Syrup-Containing D-Pinitol: Potential Use as a Novel Sweetener in Diabetes

et al. 2022

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“…Moreover, D-pinitol (DPIN), a naturally occurring inositol capable of activating the insulin pathway in peripheral tissue, has also been reported to improve insulin-resistance-associated disorders in the brain. D-pinitol lowered tau phosphorylation by regulating cyclin-dependent kinase 5 (CDK5) activity in mouse brain [ 97 ] and activated the insulin signaling pathway by increasing the phosphorylation of PI3K/Akt in rat hypothalamus [ 98 ], suggesting D-pinitol as a potential drug for the treatment of neurological disorders such as dementia.…”

Section: Mechanisms Of Hypoglycemia Induced Dementia In Patients With...mentioning

confidence: 99%

Dementia in Diabetes: The Role of Hypoglycemia

Husain,

Sarhan,

AlKhalifa

et al. 2023

IJMS

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Hypoglycemia, a common consequence of diabetes treatment, is associated with severe morbidity and mortality and has become a major barrier to intensifying antidiabetic therapy. Severe hypoglycemia, defined as abnormally low blood glucose requiring the assistance of another person, is associated with seizures and comas, but even mild hypoglycemia can cause troubling symptoms such as anxiety, palpitations, and confusion. Dementia generally refers to the loss of memory, language, problem-solving, and other cognitive functions, which can interfere with daily life, and there is growing evidence that diabetes is associated with an increased risk of both vascular and non-vascular dementia. Neuroglycopenia resulting from a hypoglycemic episode in diabetic patients can lead to the degeneration of brain cells, with a resultant cognitive decline, leading to dementia. In light of new evidence, a deeper understating of the relationship between hypoglycemia and dementia can help to inform and guide preventative strategies. In this review, we discuss the epidemiology of dementia among patients with diabetes, and the emerging mechanisms thought to underlie the association between hypoglycemia and dementia. Furthermore, we discuss the risks of various pharmacological therapies, emerging therapies to combat hypoglycemia-induced dementia, as well as risk minimization strategies.

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“…Insulin resistance contributes to the occurrence and worsening of symptoms of neurodegenerative diseases, so D-pinitol as an insulin sensitizer can play an important role in the inhibition of brain alterations. Medina-Vera et al have shown that oral supplementation of D-pinitol lowered tau phosphorylation, by regulating cyclin-dependent kinase 5 (CDK-5) activity [117]. Scyllo-inositol, as mentioned above, is another naturally occurring stereoisomer of MI and it is also considered a potential remedy for neurodegenerative diseases.…”

Section: Itselfmentioning

confidence: 99%

Cyclitols: From Basic Understanding to Their Association with Neurodegeneration

et al. 2023

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One of the most common cyclitols found in eukaryotic cells—Myo-inositol (MI) and its derivatives play a key role in many cellular processes such as ion channel physiology, signal transduction, phosphate storage, cell wall formation, membrane biogenesis and osmoregulation. The aim of this paper is to characterize the possibility of neurodegenerative disorders treatment using MI and the research of other therapeutic methods linked to MI’s derivatives. Based on the reviewed literature the researchers focus on the most common neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease and Spinocerebellar ataxias, but there are also works describing other seldom encountered diseases. The use of MI, d-pinitol and other methods altering MI’s metabolism, although research on this topic has been conducted for years, still needs much closer examination. The dietary supplementation of MI shows a promising effect on the treatment of neurodegenerative disorders and can be of great help in alleviating the accompanying depressive symptoms.

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d‐Pinitol promotes tau dephosphorylation through a cyclin‐dependent kinase 5 regulation mechanism: A new potential approach for tauopathies?

Cited by 13 publications

References 65 publications

Endocrine and Metabolic Impact of Oral Ingestion of a Carob-Pod-Derived Natural-Syrup-Containing D-Pinitol: Potential Use as a Novel Sweetener in Diabetes

Endocrine and Metabolic Impact of Oral Ingestion of a Carob-Pod-Derived Natural-Syrup-Containing D-Pinitol: Potential Use as a Novel Sweetener in Diabetes

Dementia in Diabetes: The Role of Hypoglycemia

Cyclitols: From Basic Understanding to Their Association with Neurodegeneration

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