H⁺/K⁺ ATPase expression in human parietal cells and gastric acid secretion in elderly individuals

Abstract

Acid secretion-related organelles in parietal cells do not degenerate with aging, the expression of H+ /K+ ATPase even shows a trend to increase, indicating the existence of intact molecular biological basis for acid secretion in healthy elderly individuals.

Molecular mechanisms of Wischnewski spot development on gastric mucosa in fatal hypothermia: an experimental study in rats

“…The variation of its occurrence among cases of fatal hypothermia may rely upon the consideration of factors such as the circumstances of the death and the findings at the scene of death. In addition, differences may result from severe atrophic gastritis or Helicobacter pylori infection, which may cause a low secretion of gastric acid 31 . Wischnewski spots have been recognized in cases of non-hypothermic diabetic ketoacidosis 32 and fatal burn 33 .…”

Non-invasive assessment of gastric secretory function in centenarians

“…In summary, even in the elderly, secretory patterns remain well defined in gastric ulcer patients, who generally result as being acid hyposecretors with an increased susceptibility of the gastric mucosa to damage, whereas duodenal subjects result as being hypersecretors even in geriatric age. 14 The aim to explore physiology of gastric secretion in very old subjects (over 100 years old, so called centenarians), up to now lacking, permits to asses a very important function of upper GI tract directly related with digestive process and indirectly with other aspects like the influence of gut microbiota. Moreover, it focuses on the large use of PPI for gastroprotection, being the centenarians affected by possible important comorbidities and related therapies.…”