<scp>Health-Related</scp> Quality of Life in Cancer Survivors with <scp>Chemotherapy-Induced</scp> Peripheral Neuropathy: A Randomized Clinical Trial

Bao, Ting; Baser, Raymond E.; Chen, Connie; Weitzman, Matthew; Zhang, Yi Lily; Seluzicki, Christina; Li, Qing Susan; Piulson, Lauren; Zhi, Wanqing Iris

doi:10.1002/onco.13933

Cited by 33 publications

(63 citation statements)

References 34 publications

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“…The present study examined two CIM intervention groups, treated with either acupuncture alone (group A) or a multimodal regimen combining acupuncture with other CIM therapies (group B). Although others, such as Bao et al, 29,30 compared true vs placebo/sham acupuncture for CIPN-related symptoms, the present study compared two true interventions, an approach more reflective of real-life clinical IO practice. 31,32 Although the findings do not suggest a significant difference between the two intervention subgroups, several differences are worth noting.…”

Section: Discussionmentioning

confidence: 99%

Impact of acupuncture and integrative therapies on chemotherapy‐induced peripheral neuropathy: A multicentered, randomized controlled trial

Ben‐Arye

Hausner

Samuels

et al. 2022

Cancer

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BACKGROUND:To explore the impact of acupuncture with other complementary and integrative medicine (CIM) modalities on chemotherapy-induced peripheral neuropathy (CIPN) and quality of life (QoL) in oncology patients. METHODS: In this prospective, pragmatic, and patient-preference study, patients with CIPN were treated with acupuncture and CIM therapies (intervention group) or standard care alone (controls) for 6 weeks. Patients in the intervention arm were randomized to twice-weekly acupuncture-only (group A) or acupuncture with additional manual-movement or mind-body CIM therapies (group B). Severity of CIPN was assessed at baseline and at 6 weeks using the Functional Assessment of Cancer Therapy-Taxane (FACT-Tax) tool. Other QoL-related outcomes were assessed with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC); and the Measure Yourself Concerns and Well-being questionnaire. Von Frey measurements examined perception thresholds. RESULTS: Of 168 participants, 136 underwent the study intervention (group A, 69; group B, 67), with 32 controls. Baseline-to-6-week assessment scores improved significantly in the intervention arm (vs controls) on FACT-Tax (p = .038) and emotional well-being (p = .04) scores; FACT-TAX scores for hand numbness/ tingling (p = .007) and discomfort (p < .0001); and EORTC physical functioning (p = .045). Intervention groups A and B showed improved FACT-Tax physical well-being (p < .001), FACT-TAX total score (p < .001), FACT-TAX feet discomfort (p = .003), and EORTC pain (p = .017) scores. CONCLUSIONS: Acupuncture, with or without CIM modalities, can relieve CIPN-related symptoms during oncology treatment. This is most pronounced for hand numbness, tingling, pain, discomfort, and for physical functioning.

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Section: Discussionmentioning

confidence: 99%

Impact of acupuncture and integrative therapies on chemotherapy‐induced peripheral neuropathy: A multicentered, randomized controlled trial

Ben‐Arye

Hausner

Samuels

et al. 2022

Cancer

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“…We included studies with at least one outcome measure. The severity of neurotoxicity and associated dysfunction was evaluated on the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (FACT/GOG-Ntx), which is used to assess sensory, motor, and hearing impairments associated with neuropathy ( 23 ). Ratings range from 0 to 44 points.…”

Section: Methodsmentioning

confidence: 99%

“…However, due to the poor quality of the included studies, the conclusions need further substantiation. Recently, three high-quality randomized controlled trials (RCTs) on acupuncture for CIPN treatment have been reported (22)(23)(24). Two studies revealed that, compared with placebo acupuncture, acupuncture does not reduce chemotherapyinduced neurotoxicity and functional disability (22,23).…”

Section: Introductionmentioning

confidence: 99%

“…Recently, three high-quality randomized controlled trials (RCTs) on acupuncture for CIPN treatment have been reported (22)(23)(24). Two studies revealed that, compared with placebo acupuncture, acupuncture does not reduce chemotherapyinduced neurotoxicity and functional disability (22,23). Another study showed that, compared with placebo acupuncture, acupuncture does not relieve neuropathic pain (24).…”

Section: Introductionmentioning

confidence: 99%

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The effectiveness and safety of acupuncture for chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis

Wang²,

Wu³

et al. 2022

Front. Neurol.

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ObjectivesThis systematic review and meta-analysis aimed to evaluate the effectiveness and safety of acupuncture on chemotherapy-induced peripheral neuropathy (CIPN).MethodsWe searched for relevant randomized controlled trials (RCTs) in PubMed, Cochrane Library, and Embase databases from their inception to 1 April 2022. The Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (FACT/GOG-Ntx), Brief Pain Inventory-Short Form (BPI-SF), the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Core30 (EORTC QLQ-C30), Numerical Rating Scale (NRS), and adverse events were the outcome measures. All studies had at least one of these outcome measures. Mean differences (MDs) with 95% confidence intervals (CIs) were assessed in the meta-analysis using the RevMan 5.3 software.ResultsFive studies were included in the analysis. The results showed that acupuncture and placebo acupuncture were not significantly different in reducing chemotherapy-induced neurotoxicity and functional disability (random-effects estimates; MD: 4.30; 95% CI: −0.85~9.45; P = 0.10; I2 = 74%). Acupuncture was better than placebo acupuncture in reducing pain severity and pain interference with patients' daily function (fixed-effect estimates; MD: −1.14; 95% CI: 1.87 to −0.42; P = 0.002; I2 = 13%). Acupuncture was not significantly different from placebo acupuncture in relieving CIPN symptoms (MD: −0.81; 95% CI: −2.02 to 0.40, P = 0.19). Acupuncture improved quality of life better than placebo acupuncture (MD: 10.10; 95% CI: 12.34 to 17.86, P = 0.01). No severe adverse events were recorded in all five studies.ConclusionThis meta-analysis suggests that acupuncture may be more effective and safer in reducing pain severity and pain interference with patients' daily function than placebo acupuncture. Additionally, acupuncture may improve the quality of life of patients with CIPN. However, large sample size studies are needed to confirm this conclusion.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=324930, identifier: CRD42022324930.

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“…A total of 5 RCTs investigated the effectiveness of treatment on numbness in 566 cancer survivors (24,31,33,39,58).…”

Section: Meta-analysis For Numbnessmentioning

confidence: 99%

Efficacy of treatments for pain and numbness in cancer survivors: a systematic review and meta-analysis

et al. 2022

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Background: Pain and numbness in cancer survivors frequently have negative impacts on quality of life (QoL). This meta-analysis aimed to identify the current treatment options for pain and numbness in cancer survivors and to evaluate their effects.Methods: Cancer survivors were defined as patients diagnosed with cancer who had completed active cancer treatment, whose conditions were stable, and who had no evidence of recurrent or progressive disease.A systematic search through the PubMed, MEDLINE, Embase, Cochrane Central Register of Controlled Trials, Web of Science, PsycInfo, and CINAHL databases was conducted, which targeted randomized controlled trials (RCTs) published until April 2022 that evaluated any type of treatment for pain or numbness in cancer survivors. A meta-analysis was conducted using the random-effects model to obtain the effect sizes of 7 types of treatments: opioid therapy, nonopioid pharmacotherapy, interventional therapy, acupuncture, education/cognitive behavioral therapy (CBT), physical exercise, and alternative medicine.Results: A total of 36 studies involving 2,870 cancer survivors were included. Among them, 35 (n=2,813) were included in the meta-analysis for pain. The analysis suggested that physical exercise [n=761; 13 studies;

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Health-Related Quality of Life in Cancer Survivors with Chemotherapy-Induced Peripheral Neuropathy: A Randomized Clinical Trial

Cited by 33 publications

References 34 publications

Impact of acupuncture and integrative therapies on chemotherapy‐induced peripheral neuropathy: A multicentered, randomized controlled trial

Impact of acupuncture and integrative therapies on chemotherapy‐induced peripheral neuropathy: A multicentered, randomized controlled trial

The effectiveness and safety of acupuncture for chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis

Efficacy of treatments for pain and numbness in cancer survivors: a systematic review and meta-analysis

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