<scp><i>Campylobacter</i></scp>

Wu, Zhongliang; Şahin, Orhan; Zhang, Qijing

doi:10.1002/9781119754862.ch18

Cited by 7 publications

(12 citation statements)

References 74 publications

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“…fetus causes abortions in goats, sheep and cattle, and C. hepaticus causes spotty liver disease in layer hens [19,32]. The origin of these strains is of particular importance, and it has been proposed that C. hepaticus in chickens may have an environmental origin [33,34]. The widespread resistance of Campylobacter to β-lactams, tetracyclines, fluoroquinolones and macrolides emphasises the importance of ongoing susceptibility testing.…”

Section: Campylobacter Spp Overviewmentioning

confidence: 99%

“…The pathogenic character of Campylobacter resides in the diversity of its virulence factors, including invasion of epithelial cells, adhesion to the intestinal mucosa, toxicity, motility and chemotaxis, as well as surface structure [33,49]. Adhesion-related virulence factors include the cadF gene, encoding the Campylobacter adhesion protein to fibronectin (CadF), the flaA gene, encoding the major flagellin protein FlaA and the docA gene, encoding a periplasmic cytochrome C peroxidase.…”

Section: Campylobacter Spp Overviewmentioning

confidence: 99%

“…Adhesion-related virulence factors include the cadF gene, encoding the Campylobacter adhesion protein to fibronectin (CadF), the flaA gene, encoding the major flagellin protein FlaA and the docA gene, encoding a periplasmic cytochrome C peroxidase. Other adhesion-associated factors include the FlpA, PEB1, MOMP, HtrA, CapA and JlpA [33]. Among significant virulence markers linked with invasion encompass the Campylobacter invasion antigen conferred by the ciaB gene, phospholipase A encoded by the pldA gene, invasion-associated marker (encrypted by the iam gene) and the virB11 gene [40,50].…”

Section: Campylobacter Spp Overviewmentioning

confidence: 99%

“…LOS activates Toll-like receptor 4-mediated innate immunity and resists killing via cationic antimicrobial peptides. The S-layer proteins are relevant to immune evasion and resist complement-mediated killing [33]. Of all the toxins produced by Campylobacter spp., the most characterised is the cytolethal distending toxin (CDT) encoded by the cdtABC operon.…”

Section: Campylobacter Spp Overviewmentioning

confidence: 99%

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Overview of Virulence and Antibiotic Resistance in Campylobacter spp. Livestock Isolates

Bunduruș¹,

Balta²,

Ştef³

et al. 2023

Antibiotics

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Campylobacter remains the most prevalent foodborne pathogen bacterium responsible for causing gastroenteritis worldwide. Specifically, this pathogen colonises a ubiquitous range of environments, from poultry, companion pets and livestock animals to humans. The bacterium is uniquely adaptable to various niches, leading to complicated gastroenteritis and, in some cases, difficult to treat due to elevated resistance to certain antibiotics. This increased resistance is currently detected via genomic, clinical or epidemiological studies, with the results highlighting worrying multi-drug resistant (MDR) profiles in many food and clinical isolates. The Campylobacter genome encodes a rich inventory of virulence factors offering the bacterium the ability to influence host immune defences, survive antimicrobials, form biofilms and ultimately boost its infection-inducing potential. The virulence traits responsible for inducing clinical signs are not sufficiently defined because several populations have ample virulence genes with physiological functions that reflect their pathogenicity differences as well as a complement of antimicrobial resistance (AMR) systems. Therefore, exhaustive knowledge of the virulence factors associated with Campylobacter is crucial for collecting molecular insights into the infectivity processes, which could pave the way for new therapeutical targets to combat and control the infection and mitigate the spread of MDR bacteria. This review provides an overview of the spread and prevalence of genetic determinants associated with virulence and antibiotic resistance from studies performed on livestock animals. In addition, we have investigated the relevant coincidental associations between the prevalence of the genes responsible for pathogenic virulence, horizontal gene transfer (HGT) and transmissibility of highly pathogenic Campylobacter strains.

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Section: Campylobacter Spp Overviewmentioning

confidence: 99%

Section: Campylobacter Spp Overviewmentioning

confidence: 99%

Section: Campylobacter Spp Overviewmentioning

confidence: 99%

Section: Campylobacter Spp Overviewmentioning

confidence: 99%

See 2 more Smart Citations

Overview of Virulence and Antibiotic Resistance in Campylobacter spp. Livestock Isolates

Bunduruș¹,

Balta²,

Ştef³

et al. 2023

Antibiotics

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“…[23] , Listeria monocytogenes [24,25] , Escherichia coli [26] , Staphylococcus aureus [27] , Campylobacter sp. [28] , Helicobacter pylori [29][30][31] , and many more. Upon invasion, these pathogens release their toxins and colonize the host gut, leading to a dysbiosis of the gut microbiome [32] .…”

Section: Introductionmentioning

confidence: 99%

Exploring the impact of Helicobacter pylori and potential gut microbiome modulation

Ong¹,

Loo²,

Law³

et al. 2023

Prog Micobes Mol Biol

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Helicobacter pylori is a highly prevalent bacteria that can harm humans due to its major involvement in developing gastrointestinal diseases, particularly gastric cancer. Therefore, eradicating H. pylori is one of the most important strategies for preventing gastric cancer. Antibiotic treatment has always been the gold standard treatment for H. pylori infection. However, the decreasing efficacy of antibiotic therapy due to the rising antibiotic resistance and high incidence of dysbiosis-related adverse effects resulted in eradication failure. To enhance the effectiveness of antibiotic therapy, strategies that modulate the gut microbiome were proposed to play a positive role. Generally, the integration of probiotics or symbiotic into antibiotic therapy was shown to enhance the eradication rate and reduce the incidence of adverse effects. This review aims to discuss the role and effect of H. pylori in gastric carcinogenesis and gut microbiome modulation in eradicating H. pylori infection.

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Understanding Antimicrobial Resistance in Campylobacter Isolates from Poultry Environments in Gujarat, India

Dantroliya,

Chavan,

Joshi

et al. 2024

Preprint

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Campylobacter

Cited by 7 publications

References 74 publications

Overview of Virulence and Antibiotic Resistance in Campylobacter spp. Livestock Isolates

Overview of Virulence and Antibiotic Resistance in Campylobacter spp. Livestock Isolates

Exploring the impact of Helicobacter pylori and potential gut microbiome modulation

Understanding Antimicrobial Resistance in Campylobacter Isolates from Poultry Environments in Gujarat, India

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