<scp><i>Helicobacter pylori</i></scp> infection is associated with type 2 diabetes among a middle‐ and old‐age Chinese population

Wang, Jing; Liu, Bing; Hu, Hua; Li, Xiulou; Yang, Kun; Yuan, Jing; Yao, Ping; Wei, Sheng; Wang, Youjie; Liang, Yuan; Miao, Xiaoping; Zhang, Xiaomin; Guo, Huan; Yang, Handong; Wu, Tangchun; He, Meian

doi:10.1002/dmrr.2677

Cited by 42 publications

(38 citation statements)

References 34 publications

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“…Therefore, it is plausible that chronic H. pylori infection might predispose individuals to hyperglycemia. Consistent with this notion, several studies on non‐diabetic individuals showed positive associations between H. pylori infection and glycemia or metabolic syndrome, with only a few exceptions. However, in patients with type 2 diabetes, the association between H. pylori infection and hyperglycemia remains inconclusive.…”

Section: Introductionmentioning

confidence: 84%

“…It is thus not surprising that when using serum or urine IgG assay as the diagnostic method, no relationship between H. pylori infection and glycemia exists in studies of non‐diabetic individuals. In contrast, a positive relationship between H. pylori infection and glycemia or metabolic syndrome is noted in mainly or exclusively non‐diabetic individuals, when applying diagnostic tests that verify active H. pylori infection. Thus, it is evident that active or inactive infection affects the relationship between H. pylori infection and glycemia.…”

Section: Discussionmentioning

confidence: 99%

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Helicobacter pylori eradication improves glycemic control in type 2 diabetes patients with asymptomatic active Helicobacter pylori infection

Cheng

Yang

Hung

et al. 2019

J of Diabetes Invest

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Aims/Introduction Helicobacter pylori infection is associated with insulin resistance and glycemia in non‐diabetes. However, the relationship between H. pylori infection and glycemia in diabetes remains inconclusive. Therefore, we explored the effect of H. pylori infection status and its eradication on glycemic control and antidiabetic therapy in type 2 diabetes patients. Materials and Methods A total of 549 diabetes patients were recruited for sequential two‐step approach (immunoglobulin G [IgG] serology followed by 13 C‐urea breath test [UBT] ) to discriminate “active” (IgG+ and UBT +) from “non‐active” ( UBT − or IgG−) H. pylori infection, and “past” (IgG+ but UBT −) from “never/remote” (IgG−) infection. The differences in hemoglobin A1c (A1C) and antidiabetic regimens between groups were compared. In the “active” infection group, the differences in A1C changes between participants with and without 10‐day eradication therapy were compared after 3 months. Results Despite no between‐group difference in A1C, the “active” infection group ( n = 208) had significantly more prescriptions of oral antidiabetic drug classes (2.1 ± 1.1 vs 1.8 ± 1.1, P = 0.004) and higher percentages of sulfonylurea use (67.3% vs 50.4%, P < 0.001) than the “non‐active” infection group ( n = 341). There were no differences in A1C and oral antidiabetic drug classes between “past” ( n = 111) and “never/remote” infection groups ( n = 230). Compared with the non‐eradication group ( n = 99), the eradication group ( n = 98) had significant within‐group (−0.17 ± 0.80%, P = 0.036) and between‐group (−0.23 ± 0.10%, P = 0.024) improvements in A1C. Conclusions Diabetes patients with active H. pylori infection need higher glycemic treatment intensity to achieve comparable glycemia. Furthermore, H. pylori eradication decreases A1C, and thus improves glycemic control.

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Section: Introductionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Helicobacter pylori eradication improves glycemic control in type 2 diabetes patients with asymptomatic active Helicobacter pylori infection

Cheng

Yang

Hung

et al. 2019

J of Diabetes Invest

View full text Add to dashboard Cite

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“…Moreover, H. pylori infection was also associated with a higher risk of type 2 diabetes (OR=1.08; CI: 1.02–1.14; P =.008) after adjustment for other confounders. The same authors underlined that subjects with H. pylori infection had a lower level of high‐density lipoprotein cholesterol ( P <.0001) and higher blood pressure levels ( P <.001), total cholesterol, HbA1c, and fasting blood glucose ( P <.0001) compared to H. pylori ‐negative ones . On the contrary, Tamura et al.…”

Section: Diabetes Mellitus and Metabolic Syndromementioning

confidence: 97%

Helicobacter pylori and extragastric diseases

Goni

Franceschi

2016

Helicobacter

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During the past year, many articles were published on the extragastric diseases related to Helicobacter pylori infection. This supports the theory that some microorganisms may cause diseases even far from the primary site of infection by interfering with different biologic processes. The role of H. pylori on idiopathic thrombocytopenic purpura, sideropenica anemia, and vitamin B12 deficiency is well known. On the other hand, there is a growing interest in the bacterium's association with cardiovascular, neurologic, hematologic, dermatologic, head and neck, and uro-gynecologic diseases, as well as diabetes mellitus and metabolic syndrome, with very promising results. This review has been aimed at summarizing the results of the most relevant studies published over the last year on this fascinating topic.

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“…Researchers have also found that infection with H. pylori can result in cardiovascular, hematological, hepatobiliary, and metabolic diseases (5)(6)(7)(8)(9). Currently, many epidemiological surveys have been performed to identify risk factors for H. pylori infection; age, obesity, and type 2 diabetes mellitus have been identified as risk factors (10)(11)(12)(13). In terms of diagnosis, stool antigen testing, gastric biopsies, CLO-test, and urea breath test are used.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and risk factors for Helicobacter pylori infection in southwest China: a study of health examination participants based on 13C-urea breath test

Liu¹,

Wang²,

Zhao³

et al. 2017

Turk J Med Sci

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Background/aim: Helicobacter pylori (H. pylori) has a high prevalence in developing countries. We aimed to investigate the current prevalence of H. pylori, as well as its potential serum risk factors, in a population from southwest China. Materials and methods:This cross-sectional study included 10,912 subjects who received medical examinations at the First Affiliated Hospital of Chongqing Medical University in 2014. Data regarding physical examinations and biochemical measurements were collected, and H. pylori infection was diagnosed with a 13 C-urea breath test. Logistic regression was conducted to identify the risk factors for H. pylori infection. Results:The infection rate of H. pylori was 34.4% (3750/10,912). Older age, lower albumin levels, and higher total cholesterol, LDLcholesterol, and fasting blood sugar were significantly associated with increased incidence of H. pylori infection. Moreover, logistic regression analysis showed that older age, low albumin, and hyperglycemia were independent risk factors for H. pylori infection after adjusting for other covariables. Conclusion:The results from our study showed that H. pylori was prevalent in southwest China. Older age, low albumin levels, and hyperglycemia were significant risk factors associated with H. pylori infection.

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Helicobacter pylori infection is associated with type 2 diabetes among a middle‐ and old‐age Chinese population

Abstract: These findings suggested that H. pylori infection was associated with the risk of type 2 diabetes in a middle-age and old-age Chinese population. Copyright © 2015 John Wiley & Sons, Ltd.

Cited by 42 publications

References 34 publications

Helicobacter pylori eradication improves glycemic control in type 2 diabetes patients with asymptomatic active Helicobacter pylori infection

Helicobacter pylori eradication improves glycemic control in type 2 diabetes patients with asymptomatic active Helicobacter pylori infection

Helicobacter pylori and extragastric diseases

Prevalence and risk factors for Helicobacter pylori infection in southwest China: a study of health examination participants based on 13C-urea breath test

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