<scp>I</scp>. Yeast sequencing reports. Sequencing of chromosome I of Saccharomyces cerevisiae: Analysis of the 42 kbp SP07‐CENI‐CDC15 region

Clark, Michael W.; Keng, Teresa; Storms, Reg K.; Zhong, Wuwei; Fortin, Nathalie; Zeng, Bin; Delaney, S. J.; Ouellette, B. F. Francis; Barton, Arnold B.; Kaback, David B.; Bussey, Howard

doi:10.1002/yea.320100413

Cited by 8 publications

(3 citation statements)

References 29 publications

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“…We cannot conclude whether this ORF codes for a yeast PDI, but a related function is not to be excluded. A data base search showed that the tRNA alanine (UGC) sequence deduced from this gene corresponds to the DNA sequence published by Drabkin and RajBhandary (1985) for this tRNA species and later assigned to chromosome I (Clark et al, 1994). Therefore this is the second gene described for this tRNA species.…”

Section: Orfs Showing a Similarity With Known Genessupporting

confidence: 59%

DNA sequence analysis of theVPH1-SNF2 region on chromosome XV ofSaccharomyces cerevisiae

Chéret¹,

Bernardi²,

Sor³

1996

Yeast

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Section: Orfs Showing a Similarity With Known Genessupporting

confidence: 59%

DNA sequence analysis of theVPH1-SNF2 region on chromosome XV ofSaccharomyces cerevisiae

Chéret¹,

Bernardi²,

Sor³

1996

Yeast

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“…This appears to be the case for chromosomes I11 and XIV, where five pairs of duplicate genes (coding for three proteins and two tRNAs) have been found flanking the centromeres, but these are interspersed with genes unique to one chromosome (Lalo et al, 1993). Extensive sequence data around centromeres is at present only available for six of the 16 yeast chromosomes: I, 11, 111, IV, XI and XIV (Clark et al, 1993;this study;Oliver et al, 1992;Mann and Davis, 1986;Dusterhoft and Philippsen, 1992;Lalo et al, 1993), and already two pairs of duplicate centromeres are apparent. Since duplication of a centromere is likely to lead to (Chen et al, 1993; nucleotides 1518-2222 of database accession number L07603) and Streptomycesfradiae (Siemieniak et al, 1990; nucleotides 47445109 and 51 11-5521 of accession number M29297).…”

Section: Similarity Between the Cen2 And Cen4 Regionsmentioning

confidence: 95%

II. Yeast sequencing reports. Sequence around the centromere ofSaccharomyces cerevisiae chromosome II: Similarity ofCEN2 toCEN4

Wolfe

Lohan

1994

Yeast

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We report the sequence of a 12 kilobase region spanning the centromere of Saccharomyces cerevisiae chromosome II. The sequence from the left arm includes genes for histones H2A and H2B. The sequence from the right arm includes a gene that probably encodes a novel trehalase, as well as the COQ1 gene (for an enzyme involved in coenzyme Q biosynthesis), and an open reading frame with significant similarity to bacterial genes of unknown function. The trehalase gene (YBR0106) on chromosome II is located beside the centromere and transcribed towards it. This is identical to the arrangement of the neutral trehalase gene (NTH1) beside the centromere of chromosome IV. The centromere regions of chromosomes II and IV may therefore have arisen through a duplication of the centromere region of an ancestral chromosome. The YBR0106 and NTH1 proteins are 77% identical in predicted amino acid sequence, but there is no pronounced sequence similarity between the two centromeres (CEN2 and CEN4) outside of the universally conserved CDE I and CDE III elements. The genes flanking the centromere and trehalase genes differ between the two chromosomes, so the similarity between chromosomes II and IV may be less extensive than that recently reported between chromosomes III and XIV.

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“…Erp2 is a member of the p24 family involved in ER to Golgi transport [28]. FUN14 encodes a protein of so far unknown function (Function unknown now, [29]) that was found in two high-throughput studies to be a mitochondrial protein [30,31]. We cloned the FUN14 coding sequence in an ARS/CEN plasmid containing a rather strong triose phosphate isomerase (TPI) promoter.…”

Section: Mcp3 Is a High-copy Suppressor Of Cells Lacking Mdm10mentioning

confidence: 99%

Mcp3 is a novel mitochondrial outer membrane protein that follows a unique IMP‐dependent biogenesis pathway

et al. 2016

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Mitochondria are separated from the remainder of the eukaryotic cell by the mitochondrial outer membrane (MOM). The MOM plays an important role in different transport processes like lipid trafficking and protein import. In yeast, the ER-mitochondria encounter structure (ERMES) has a central, but poorly defined role in both activities. To understand the functions of the ERMES, we searched for suppressors of the deficiency of one of its components, Mdm10, and identified a novel mitochondrial protein that we named Mdm10 complementing protein 3 (Mcp3). Mcp3 partially rescues a variety of ERMES-related phenotypes.We further demonstrate that Mcp3 is an integral protein of the MOM that follows a unique import pathway. It is recognized initially by the import receptor Tom70 and then crosses the MOM via the translocase of the outer membrane. Mcp3 is next relayed to the TIM23 translocase at the inner membrane, gets processed by the inner membrane peptidase (IMP) and finally integrates into the MOM. Hence, Mcp3 follows a novel biogenesis route where a MOM protein is processed by a peptidase of the inner membrane.

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I. Yeast sequencing reports. Sequencing of chromosome I of Saccharomyces cerevisiae: Analysis of the 42 kbp SP07‐CENI‐CDC15 region

Cited by 8 publications

References 29 publications

DNA sequence analysis of theVPH1-SNF2 region on chromosome XV ofSaccharomyces cerevisiae

DNA sequence analysis of theVPH1-SNF2 region on chromosome XV ofSaccharomyces cerevisiae

II. Yeast sequencing reports. Sequence around the centromere ofSaccharomyces cerevisiae chromosome II: Similarity ofCEN2 toCEN4

Mcp3 is a novel mitochondrial outer membrane protein that follows a unique IMP‐dependent biogenesis pathway

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