<scp><i>T</i></scp><i>ephrosia toxicaria</i> <scp>P</scp>ers. reduces temporomandibular joint inflammatory hypernociception: The involvement of the <scp>HO</scp>‐1 pathway

Val, Danielle Rocha do; Bezerra, Mirna Marques; Silva, A.A.R.; Pereira, Karuza Maria Alves; Lemos, Jonas Cavalcante; Arriaga, Natacha Campos; Vasconcelos, Jackson Nunes e; Benevídes, Norma Maria Barros; Pinto, Vicente de Paulo Teixeira; Cristino-Filho, Gerardo; Brito, Gerly A. C.; Silva, F.R.L.; Santiago, Gilvandete Maria Pinheiro; Arriaga, Ângela M. C.; Chaves, Hellíada Vasconcelos

doi:10.1002/j.1532-2149.2014.488.x

Cited by 22 publications

(21 citation statements)

References 35 publications

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“…The use of CFA to model RA as well as persistent TMJ inflammation is well established, inducing edema in the joint and behavioral hypersensitivity (Spears et al, 2003), symptoms similar to clinical patients (Arthritis Foundation, http://www.arthritis.org). On a technical note, similar to a previous study, we tested the area over the TMJ with von Frey filaments (do Val et al, 2014). In our experiments, the stimulated skin and underlying tissue was relatively insensitive, requiring higher strength von Frey filaments to elicit a response compared to the whiskerpad and feet.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory ‘double hit’ model of temporomandibular joint disorder with elevated CCL2, CXCL9, CXCL10, RANTES and behavioural hypersensitivity in TNFR1/R2−/− mice

McIlwrath

Nesemeier

et al. 2017

European Journal of Pain

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Background Patients with temporomandibular joint disorders (TMD), reactive arthritis, and rheumatoid arthritis often have combined etiology of hereditary and microenvironmental factors contributing to joint pain. Multiple clinical and animal studies indicate “double-hit” inflammatory insults can cause chronic inflammation. The first inflammatory insult primes the immune system and subsequent insults elicit amplified responses. The present “double hit” study produced a chronic orofacial pain model in mice with genetic deletion of both TNFα receptors (TNFR1/R2−/−), investigating the main nociceptive signaling pathways in comparisons to wild type mice. Methods An initial inflammatory insult was given unilaterally into the temporomandibular joint (TMJ). Secondary hypersensitivity was tested on the skin over the TMJ throughout the experiment. Three weeks later after complete reversal of hypersensitivity, a second inflammatory insult was imposed on the colon. Pharmacological interventions were tested for efficacy after week 10 when hypersensitivity was chronic in TNFR1/R2−/− mice. Serum cytokines were analyzed Days 1, 14, and Week 18. Results The double hit insult produced chronic hypersensitivity continuing through the four month experimental timeline in the absence of TNFα signaling. P2X7 and NMDA receptor antagonists temporarily attenuated chronic hypersensitivity. Serum cytokine/chemokine analysis on Day 14 when CFA induced hypersensitivity was resolved identified increased levels of pro-inflammatory cytokines CCL2, CXCL9, CXCL10, RANTES and decreased levels of anti-inflammatory cytokines IL-1ra and IL-4 in TNFR1/R2−/− compared to WT mice. Conclusions These data suggest a causal feed-forward signaling cascade of these little studied cytokines have the potential to cause recrudescence in this orofacial inflammatory pain model in the absence of TNFα signaling.

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Section: Discussionmentioning

confidence: 99%

Inflammatory ‘double hit’ model of temporomandibular joint disorder with elevated CCL2, CXCL9, CXCL10, RANTES and behavioural hypersensitivity in TNFR1/R2−/− mice

McIlwrath

Nesemeier

et al. 2017

European Journal of Pain

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“…Chev., also named T. toxicaria Pers, is a shrub that has been used in Amazonian countries traditional medicine to alleviate pain and inflammation [ 1 ]. Tephrosia (Fabaceae) is a large perennial genus, distributed in warm regions of both hemispheres [ 2 ] known by several important pharmacological activities such as analgesic [ 3 , 4 ], anti-inflammatory [ 3 – 6 ], antioxidant [ 5 – 8 ], anticancer [ 9 , 10 ], insecticidal [ 11 ], larvicidal [ 8 ], and antiviral activities [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, T. sinapou extract inhibits inflammatory hyperalgesia in mice by activating an opioid receptor-dependent mechanism [ 3 ]. The antinociceptive and anti-inflammatory efficacy of T. sinapou in the model of zymosan-induced temporomandibular joint inflammatory hyperalgesia in rats depends, at least in part, on the integrity of the HO-1 pathway [ 4 ]. Importantly, this plant is effective and safe, since the therapeutic dose did not produce any signs of toxicity [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…The antinociceptive and anti-inflammatory efficacy of T. sinapou in the model of zymosan-induced temporomandibular joint inflammatory hyperalgesia in rats depends, at least in part, on the integrity of the HO-1 pathway [ 4 ]. Importantly, this plant is effective and safe, since the therapeutic dose did not produce any signs of toxicity [ 4 ]. T. sinapou is a source of flavonoids and rotenoids that possess various biological effects [ 3 , 4 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…Importantly, this plant is effective and safe, since the therapeutic dose did not produce any signs of toxicity [ 4 ]. T. sinapou is a source of flavonoids and rotenoids that possess various biological effects [ 3 , 4 , 10 ]. In fact, plant extracts containing flavonoids are reported to own antinociceptive, anti-inflammatory, and antioxidant activities [ 15 – 19 ].…”

Section: Introductionmentioning

confidence: 99%

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Antinociceptive Effect ofTephrosia sinapouExtract in the Acetic Acid, Phenyl-p-benzoquinone, Formalin, and Complete Freund’s Adjuvant Models of Overt Pain-Like Behavior in Mice

et al. 2016

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Tephrosia toxicaria, which is currently known as Tephrosia sinapou (Buc'hoz) A. Chev. (Fabaceae), is a source of compounds such as flavonoids. T. sinapou has been used in Amazonian countries traditional medicine to alleviate pain and inflammation. The purpose of this study was to evaluate the analgesic effects of T. sinapou ethyl acetate extract in overt pain-like behavior models in mice by using writhing response and flinching/licking tests. We demonstrated in this study that T. sinapou extract inhibited, in a dose (1–100 mg/kg) dependent manner, acetic acid- and phenyl-p-benzoquinone- (PBQ-) induced writhing response. Furthermore, it was active via intraperitoneal, subcutaneous, and peroral routes of administration. T. sinapou extract also inhibited formalin- and complete Freund's adjuvant- (CFA-) induced flinching/licking at 100 mg/kg dose. In conclusion, these findings demonstrate that T. sinapou ethyl acetate extract reduces inflammatory pain in the acetic acid, PBQ, formalin, and CFA models of overt pain-like behavior. Therefore, the potential of analgesic activity of T. sinapou indicates that it deserves further investigation.

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Appraisal of Medicinal Plants with Anticancer Properties in South America

Suárez

Chávez

2018

Anticancer Plants: Properties and Application

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Tephrosia toxicaria Pers. reduces temporomandibular joint inflammatory hypernociception: The involvement of the HO‐1 pathway

Abstract: T. toxicaria did not produce any signs of toxicity and effectively decreased zymosan-induced TMJ inflammatory hypernociception dependent, at least in part, upon the HO-1 pathway integrity.

Cited by 22 publications

References 35 publications

Inflammatory ‘double hit’ model of temporomandibular joint disorder with elevated CCL2, CXCL9, CXCL10, RANTES and behavioural hypersensitivity in TNFR1/R2−/− mice

Inflammatory ‘double hit’ model of temporomandibular joint disorder with elevated CCL2, CXCL9, CXCL10, RANTES and behavioural hypersensitivity in TNFR1/R2−/− mice

Antinociceptive Effect ofTephrosia sinapouExtract in the Acetic Acid, Phenyl-p-benzoquinone, Formalin, and Complete Freund’s Adjuvant Models of Overt Pain-Like Behavior in Mice

Appraisal of Medicinal Plants with Anticancer Properties in South America

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