<scp>IL</scp>‐17 eliminates therapeutic effects of oral tolerance in murine airway allergic inflammation

Kawakami, Hidenori; Koya, Toshiyuki; Kagamu, Hiroshi; Kimura, Yo; Sakamoto, Hirotaka; Yamabayashi, Cristiane; Furukawa, Toshiki; Sakagami, Takuro; Miyabayashi, Takao; Hasegawa, Takashi; Suzuki, Eiichi; Narita, Ichiei

doi:10.1111/j.1365-2222.2012.04006.x

Cited by 16 publications

(14 citation statements)

References 39 publications

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“…Increased levels of pro-inflammatory cytokines in BALF of OVA-sensitized animals were observed in reports, such as IL-1β, IL-6, IL-17 and TNF-α [43]–[46]. In the current study, we analyzed the levels of TNF-α and IL-6 in BALF to further evaluate the inflammation in lung.…”

Section: Discussionmentioning

confidence: 82%

Oral Administration of Heat-Inactivated Lactobacillus plantarum K37 Modulated Airway Hyperresponsiveness in Ovalbumin-Sensitized BALB/c Mice

Liu¹,

Liao²,

Chen³

et al. 2014

PLoS ONE

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This study aimed to investigate the anti-allergic effects of Lactobacillus plantarum K37 (K37) on airway hyperresponsiveness (AHR) and systemic allergic responses in ovalbumin (OVA)-sensitized and -challenged BALB/c mice. Heat-inactivated K37 (105, 107, and 109 CFU/mouse, day) were orally administered to OVA-sensitized BALB/c mice to investigate their effects on AHR, immunoglobulin (Ig) and cytokine production. The results showed that K37 dose-dependently lowered the serum levels of IgE, OVA-specific IgE and OVA-specific IgG1, ameliorated AHR induced by methacholine and suppressed eosinophil infiltration in bronchoalveolar lavage fluid (BALF). The cytokine production in spleen cells culture and BALF showed that K37 drove the immune responses toward T-helper cell type 1 (Th1) responses, elevated levels of IL-2 and IFN-γ, and reduced of IL-4, IL-5 and IL-13. K37 also improved cell infiltration in lung sections. Our results demonstrated that oral administration of K37 alleviated effectively the allergic responses in vivo. Thus, K37 can be a good source material and a promising candidate for prophylactic and therapeutic treatments of allergic diseases, like asthma.

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Section: Discussionmentioning

confidence: 82%

Oral Administration of Heat-Inactivated Lactobacillus plantarum K37 Modulated Airway Hyperresponsiveness in Ovalbumin-Sensitized BALB/c Mice

Liu¹,

Liao²,

Chen³

et al. 2014

PLoS ONE

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“…The expression of VEGF and VEGFR in asthma patients increased accompanied by an increased number and size of blood vessels in asthmatic airways [63]. Interleukin-(IL-) 17 may inhibit the induction of tolerance to antigen through inducing IL-6 production, thereby suppressing the expansion of Foxp3-positive regulatory T (Treg) cells [64]. IL-5 is directly involved in recruiting eosinophils to the lung.…”

Section: Resultsmentioning

confidence: 99%

A Network-Based Systematic Study for the Mechanism of the Treatment of Zhengs Related to Cough Variant Asthma

Chen

Zhang

Chen

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Traditional Chinese medicine (TCM) has shown significant efficacy in the treatment of cough variant asthma (CVA), a special type of asthma. However, there is shortage of explanations for relevant mechanism of treatment. As Zhengs differentiation is a critical concept in TCM, it is necessary to explain the mechanism of treatment of Zhengs. Based on TCM clinical cases, this study illustrated the mechanism of the treatment of three remarkably relevant Zhengs for CVA: “FengXieFanFei,” “FeiQiShiXuan”, and “QiDaoLuanJi.” To achieve this goal, five steps were carried out: (1) determining feature Zhengs and corresponding key herbs of CVA by analyses of clinical cases; (2) finding out potential targets of the key herbs and clustering them based on their functional annotations; (3) constructing an ingredient-herb network and an ingredient network; (4) identifying modules of the ingredient network; (5) illustrating the mechanism of the treatment by further mining the latent biological implications within each module. The systematic study reveals that the treatment of “FengXieFanFei,” “FeiQiShiXuan,” and “QiDaoLuanJi” has effects on the regulation of multiple bioprocesses by herbs containing different ingredients with functions of steroid metabolism regulation, airway inflammation, and ion conduction and transportation. This network-based systematic study will be a good way to boost the scientific understanding of mechanism of the treatment of Zhengs.

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“…In our previous study, AHR and allergic inflammation were ameliorated through oral antigen-mediated induction of gut Treg cells, inhibited by endogenous and exogenous IL-17 [15] . Oral administration of ATRA with OVA was thought to induce gut Treg cells, which presumably moved to the lung after the antigen challenges.…”

Section: Discussionmentioning

confidence: 99%

“…We previously reported that both transfer of T helper (Th) 17 cells or administration of IL-17 in the induction phase of oral tolerance abolished the therapeutic effects of oral tolerance by upregulating IL-6 production in Peyer's patch (PP) in a murine asthma model [15] . The vitamin A metabolite, retinoic acid (RA), has also been reported to enhance the expression of α4β7 integrin and C-C chemokine receptor type 9 on T cells upon activation, imprinting them with gut tropism [16] .…”

Section: Introductionmentioning

confidence: 99%

The Effects of All-Trans Retinoic Acid on the Induction of Oral Tolerance in a Murine Model of Bronchial Asthma

Sakamoto

Koya²,

Tsukioka³

et al. 2015

Int Arch Allergy Immunol

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Background: Active suppression induced by regulatory T (Treg) cells is reported to be one of the mechanisms involved in oral tolerance. All-trans retinoic acid (ATRA) has been reported to affect Treg cell differentiation. The present study examined the effects of ATRA on the induction of oral tolerance in a murine model of bronchial asthma. Methods: BALB/c mice were sensitized to and challenged with ovalbumin (OVA) through feeding followed by OVA challenges. In some study groups ATRA was orally administered concomitantly with OVA feeding either in the presence or absence of the retinoic acid receptor antagonist LE135. Lung CD4⁺ T cells were isolated from mice exposed to ATRA and/or OVA, and transferred to control mice. Airway hyperresponsiveness (AHR), cell counts and cytokine levels in bronchoalveolar lavage (BAL) fluid, and lung histology were assessed. Results: Concomitant administration of ATRA with OVA ameliorated AHR, airway eosinophilia, elevation of cytokines in BAL fluid and goblet cell metaplasia. The proportion of Treg cells in the lungs was increased in mice treated with OVA and ATRA, as compared to those treated with OVA only. Transfer of lung CD4⁺ T cells from mice treated with OVA and ATRA induced suppression of AHR and airway inflammation. LE135 completely reversed the effects of ATRA on AHR, airway allergic inflammation and the number of Treg cells in the lungs. Conclusion: These data suggested that oral administration of ATRA with OVA had the potential to enhance oral tolerance in this murine model of bronchial asthma. These effects were mediated, at least in part, by Treg cell expansion.

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IL‐17 eliminates therapeutic effects of oral tolerance in murine airway allergic inflammation

Abstract: These data suggest that IL-17 may inhibit the induction of tolerance to antigen through, at least in part augmenting IL-6 production, thereby suppressing the expansion of Treg cells.

Cited by 16 publications

References 39 publications

Oral Administration of Heat-Inactivated Lactobacillus plantarum K37 Modulated Airway Hyperresponsiveness in Ovalbumin-Sensitized BALB/c Mice

Oral Administration of Heat-Inactivated Lactobacillus plantarum K37 Modulated Airway Hyperresponsiveness in Ovalbumin-Sensitized BALB/c Mice

A Network-Based Systematic Study for the Mechanism of the Treatment of Zhengs Related to Cough Variant Asthma

The Effects of All-Trans Retinoic Acid on the Induction of Oral Tolerance in a Murine Model of Bronchial Asthma

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