<scp>IL</scp>1A (‐889) gene polymorphism is associated with the effect of diet as a risk factor in Acne Vulgaris

Ibrahim, Adel A.; Salem, Rehab Mohammed; El-Shimi, O.S.; Baghdady, Shaymaa Mohamed; Hussein, Shimaa

doi:10.1111/jocd.12516

Cited by 16 publications

(15 citation statements)

References 19 publications

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“…Both "hair loss" and "acne" may be associated with emotional stress. [20][21][22][23][24] "Hair loss" search term was at the highest point in the second month of the COVID-19 pandemic in Turkey. Of note, this result may indicate that the short term (<2 months) is more important than the long term in the context of stress period for hair loss.…”

Section: Discussionmentioning

confidence: 99%

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Analysis of dermatologic conditions in Turkey and Italy by using Google Trends analysis in the era of the COVID ‐19 pandemic

Kutlu

2020

Dermatologic Therapy

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Many areas of life including patterns of dermatological diseases that patient attend to the hospital were tremendously affected by implementing stay‐at‐home orders during the COVID‐19 pandemic. We aimed to identify the dermatologic interest of the public during the COVID‐19 pandemic by using Google Trends. The terms “acne”, “hair loss”, “eczema”, “genital warts”, “molluscum contagiosum”, “botox”, “skin cancer”, “sunscreen” were analyzed on first April, first May, first June 2020, and the corresponding period of the previous year in Turkey and Italy by using Google Trends. The searching spectrum was between 3first March 2019‐first June 2020. The relative change of search term “acne” was +10, +29, +13/ ‐1, +17,+33, “hair loss” was +14, +40, +16/+3, +16, +15, and “eczema” was +2, +34, −4/ +3, +25, +18, on the other hand, the relative change of the “genital warts” was −15, −48, +10/ ‐44, −30, +18 and “molluscum contagiosum” was −12, −2, −4/ ‐4, −1, −12 while “botox” was, −10, −43, −8/ ‐41, −31, +4, “skin cancer” was −27, −38, −38/−22,+33, −7 and sunscreen was −6, −25, −71/−13,0,‐45 in Turkey/Italy on 1 st April, 1 st May, and 1 st June, 2020, respectively. A statistically significant positive correlation was found between the number of COVID‐19 cases in Turkey and search terms of the general dermatology group during the COVID‐19 pandemic ( P < 0.05). The search terms including “acne”, “eczema”, “hair loss” appears to be increasing while “molluscum contagiosum”, “genital warts” “botox”, “skin cancer”, and “sunscreen” decreasing in the era of the COVID‐19 pandemic. Understanding the trends and impacts of dermatologic diseases on public perceptions during the COVID‐19 pandemic will allow for better preparation of dermatologists. This article is protected by copyright. All rights reserved.

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Section: Discussionmentioning

confidence: 99%

“…We also found that “hair loss” and “acne” search terms were increased in both countries in April and May 2020. Both “hair loss” and “acne” may be associated with emotional stress 20‐24 . “Hair loss” search term was at the highest point in the second month of the COVID‐19 pandemic in Turkey.…”

Section: Discussionmentioning

confidence: 99%

Analysis of dermatologic conditions in Turkey and Italy by using Google Trends analysis in the era of the COVID ‐19 pandemic

Kutlu

2020

Dermatologic Therapy

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“…30 La severidad del acné en la adolescencia es más común a mayor edad, raza blanca, género femenino y mejor nivel socioeconómico. 31 Dentro de los factores de riesgo de acné moderado/severo se encuentran: antecedentes familiares (polimorfismo genético IL-1A -889 entre otros), 32 índice de masa corporal mayor de 23 Kg/m 2 , consumo de leche, inicio temprano de acné comedonal, altos niveles séricos de hormona dehidroepiandrosterona sulfato (DHEAS), 25,28 y el contenido y composición de los lípidos de la superficie de la piel. 33 La oclusión de la superficie de la piel con productos grasosos, la ropa y la sudoración pueden empeorar el acné.…”

Section: Epidemiologíaunclassified

Acné pediátrico

Castro¹,

Gutiérrez²

2021

Acta Pediatr Mex

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El acné vulgar es una enfermedad común, inflamatoria y multifactorial de la unidad pilosebácea que afecta, primariamente, a los adolescentes; sin embargo, puede encontrarse a cualquier edad. Cuando ocurre entre el nacimiento y los 12 años se denomina acné pediátrico, el que con base en la edad de inicio se ha categorizado en acné neonatal, infantil, de la mediana niñez y preadolescente. La importancia de esta categorización reside en los procesos etiopatogénicos implicados, curso, complicaciones y pronóstico.El acné neonatal que coexiste en las primeras 8 semanas de la vida tiene excelente pronóstico y no requiere tratamiento. El acné infantil ocurre de 8 semanas a 1 año; la mayoría cursa sin complicaciones y tiene la implicación de padecer acné severo en la adolescencia. El acné de la mediana niñez aparece entre 1 y 7 años, periodo en el que virtualmente no existen hormonas adrenales ni gonadales, por lo que debe investigarse una endocrinopatía subyacente. En cambio, el acné preadolescente, entre los 7 y 12 años, es muy frecuente y considerado normal. Sin embargo, en todo paciente con síntomas y signos de hiperandrogenismo deberá investigarse un trastorno endocrinológico.El conocimiento del acné pediátrico permitirá al médico tratante o al pediatra sospechar la existencia de una enfermedad subyacente. La influencia de la dieta occidental en la severidad del acné se ha demostrado y está adquiriendo mayor relevancia. El tratamiento pronto y efectivo del acné reduce la repercusión psicosocial del paciente. Sin embargo, se requieren investigaciones futuras para determinar ese efecto en el paciente pediátrico.

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“…Acne vulgaris is a multifactorial inflammatory skin condition resulting from the integration between multiple factors including androgen‐induced increase in sebum secretion, altered keratinization, inflammation, pilosebaceous unit colonization by Cutibacterium acnes ( C . acnes ), delayed‐type immune reaction, diet, and genetic factors 1 …”

Section: Introductionmentioning

confidence: 99%

“…

Acne vulgaris is a multifactorial inflammatory skin condition resulting from the integration between multiple factors including androgeninduced increase in sebum secretion, altered keratinization, inflammation, pilosebaceous unit colonization by Cutibacterium acnes (C. acnes), delayed-type immune reaction, diet, and genetic factors. 1 The proteolytic enzymes, matrix metalloproteinases (MMPs) and intrinsic tissue inhibitors of metalloproteinases (TIMPs), regulate extracellular matrix (ECM) remodeling and inflammatory signaling.

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confidence: 99%

MMP‐1 (519 A/G) and TIMP‐1 (372 T/C) genes polymorphism in an Egyptian sample of Acne vulgaris patients

Mohammed¹,

Sabry

Ameen

et al. 2021

J of Cosmetic Dermatology

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Background Different Matrix metalloproteinases (MMPs) family members may be implicated in acne vulgaris development. However, there are no published data about the role of MMP‐1 and TIMP‐1 gene polymorphisms in acne vulgaris development. Aims To evaluate the association between MMP‐1 (519 A/G) and TIMP‐1 (372 T/C) gene polymorphisms and the risk of developing acne vulgaris among a sample of Egyptian acne patients. Patients/Methods This case‐control study included 100 acne vulgaris patients and 120 apparently healthy control subjects. Acne severity was assessed according to Global Acne Grading System (GAGS). MMP‐1 (519 A/G) and TIMP‐1 (372 T/C) gene polymorphisms were investigated using RFLP‐PCR technique. Results The MMP‐1 (519 A/G) AG and GG genotypes and G allele increase the risk of acne vulgaris~2–3 folds. In female patients, TIMP‐1 (372 C/T) TT genotype and T allele showed significantly higher frequency in cases compared with the control group (p = 0.004, 0.001 respectively) with a higher risk to develop acne. On the other hand, in male patients, there was insignificant difference between the frequency of alleles in patients and control subjects. TIMP‐1 (372C/T) TT genotype has been shown to be significantly detected in the studied female patients associated with the positive family history of the disease, and it increases the risk of back affection, severe acne grade development, and the liability to postacne scar formation. Conclusion MMP‐1 (519 A/G) and TIMP‐1 (372 T/C) gene polymorphisms may be related to acne vulgaris development.

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IL1A (‐889) gene polymorphism is associated with the effect of diet as a risk factor in Acne Vulgaris

Abstract: IL-1A (-889) gene polymorphism has a role in the pathogenesis of acne vulgaris. We suggest that the triggering or exacerbating effect of diet on acne may be related to IL-1A (-889) gene polymorphism.

Cited by 16 publications

References 19 publications

Analysis of dermatologic conditions in Turkey and Italy by using Google Trends analysis in the era of the COVID ‐19 pandemic

Analysis of dermatologic conditions in Turkey and Italy by using Google Trends analysis in the era of the COVID ‐19 pandemic

Acné pediátrico

MMP‐1 (519 A/G) and TIMP‐1 (372 T/C) genes polymorphism in an Egyptian sample of Acne vulgaris patients

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