IL-1A (-889) gene polymorphism has a role in the pathogenesis of acne vulgaris. We suggest that the triggering or exacerbating effect of diet on acne may be related to IL-1A (-889) gene polymorphism.

The detected hormonal disturbance in male psoriasis patients may be a cause of the associated erectile dysfunction beside the known effect of chronic systemic disease on patients' erectile function.

Background Acne vulgaris (AV) is an inflammatory skin disorder that may be associated with metabolic disorders. The relation between lipid profile in acne is not widely investigated. Chitinase‐3‐like protein 1 (YKL‐40) has been found to be implicated in different inflammatory conditions. Aims We aimed at investigating the role YKL‐40 in acne pathogenesis and associated dyslipidemia in acne patients. Patients/Methods This study included 50 acne vulgaris patients and 30 matched control subjects. Serum YKL‐40 in addition to lipid profile were assessed in all studied subjects. Results Serum YKL‐40 level was significantly elevated in acne patients than healthy controls (P < .001). We also found a significant positive correlations between serum YKL‐40, serum TGs, TC, and LDL‐C (P value: .022, .001, .017 respectively) while, a significant negative correlation between serum YKL‐40 and HDL‐c (P value: .036) was detected. Conclusion Our study results suggest that YKL‐40 might have a role in AV pathogenesis. In addition, it could provide a new potential link between inflammation and dyslipidemia observed in acne patients.

Serum levels of hepcidin and CRP are promising markers, which may be considered as objective tools to predict the possibility of postacne scarring.

Summary Background Acne vulgaris is a common chronic inflammatory skin disease involving pilosebaceous units. Adipokines are secreted by adipose tissue and function as signaling networks communicating it with different organs. They may have role in pathogenesis of acne vulgaris and the associated insulin resistance. Irisin, a hormone like myokine, is one of adipokines with anti‐inflammatory, anti‐oxidant, and anti‐diabetic effects. Aims We aimed at evaluation of serum irisin level in patients with acne vulgaris to assess its correlation with disease pathogenesis. Patients and Methods Serum irisin level was measured by an ELISA technique in 60 acne vulgaris patients and 60 apparently healthy controls. Insulin resistance was calculated by Homeostasis Model Assessment of Insulin Resistance index. Results Serum irisin level was significantly lower in acne vulgaris patients than control group (P < 0.001). It showed a significant negative correlation with insulin resistance among patients (P 0.012). Moreover, it was decreasing significantly with the increase in disease severity (P 0.004). Conclusions Our results revealed that lower serum irisin not only to be a biomarker of disease pathogenesis but also to be a potential prognostic predictor for severity in acne vulgaris.