<scp>IL</scp>‐33/<scp>ST</scp>2 axis affects the polarization and efferocytosis of decidual macrophages in early pregnancy

Sheng, Yan-Ran; Hu, Wenting; Wei, Chunyan; Tang, Lingli; Liu, Yukai; Liu, Yuyin; Qiu, Jianping; Li, Da‐Jin; Zhu, Xiao‐Yong

doi:10.1111/aji.12836

Cited by 31 publications

(21 citation statements)

References 32 publications

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“…IL-33, a member of the IL-1 family, induced the proliferation of cytotrophoblasts (CTB) and triggered the migration of EVT by interacting with the IL-33 ligand ST2L (102). Dysregulation of the IL-33/ST2 signaling pathway may skew normal pregnancy-derived dMϕs and U937 cells into the M1 phenotype (103). Meng et al observed that the levels of RANKL/RANK were reduced in villi and decidua from miscarriage patients compared to those from normal pregnancy patients.…”

Section: The Roles Of Macrophages In Pregnancy Complicationsmentioning

confidence: 99%

Macrophage Polarization in Physiological and Pathological Pregnancy

2019

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The immunology of pregnancy is complex and poorly defined. During the complex process of pregnancy, macrophages secrete many cytokines/chemokines and play pivotal roles in the maintenance of maternal-fetal tolerance. Here, we summarized the current knowledge of macrophage polarization and the mechanisms involved in physiological or pathological pregnancy processes, including miscarriage, preeclampsia, and preterm birth. Although current evidence provides a compelling argument that macrophages are important in pregnancy, our understanding of the roles and mechanisms of macrophages in pregnancy is still rudimentary. Since macrophages exhibit functional plasticity, they may be ideal targets for therapeutic manipulation during pathological pregnancy. Additional studies are needed to better define the functions and mechanisms of various macrophage subsets in both normal and pathological pregnancy.

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Section: The Roles Of Macrophages In Pregnancy Complicationsmentioning

confidence: 99%

Macrophage Polarization in Physiological and Pathological Pregnancy

2019

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“…During the menstrual cycle, in the endometrium, immature DC-SIGN + cells can transform into mature CD83 + DCs by exposure to antigen or inflammatory cytokines, which suggest that DCs are involved in the uterus defense against pathogens (103). Kammerer et al reported that decidual DC-SIGN + cells in situ and in vitro exhibit similar functions and phenotypes as immature DCs and these cells could mature in cell culture (104, 105).…”

Section: Dendritic Cellsmentioning

confidence: 99%

Dynamic Function and Composition Changes of Immune Cells During Normal and Pathological Pregnancy at the Maternal-Fetal Interface

2019

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A successful pregnancy requires a fine-tuned and highly regulated balance between immune activation and embryonic antigen tolerance. Since the fetus is semi-allogeneic, the maternal immune system should exert tolerant to the fetus while maintaining the defense against infection. The maternal-fetal interface consists of different immune cells, such as decidual natural killer (dNK) cells, macrophages, T cells, dendritic cells, B cells, and NKT cells. The interaction between immune cells, decidual stromal cells, and trophoblasts constitute a vast network of cellular connections. A cellular immunological imbalance may lead to adverse pregnancy outcomes, such as recurrent spontaneous abortion, pre-eclampsia, pre-term birth, intrauterine growth restriction, and infection. Dynamic changes in immune cells at the maternal-fetal interface have not been clearly stated. While many studies have described changes in the proportions of immune cells in the normal maternal-fetus interface during early pregnancy, few studies have assessed the immune cell changes in mid and late pregnancy. Research on pathological pregnancy has provided clues about these dynamic changes, but a deeper understanding of these changes is necessary. This review summarizes information from previous studies, which may lay the foundation for the diagnosis of pathological pregnancy and put forward new ideas for future studies.

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“…However, the majority of decidual macrophages do not fit the M1‐M2 paradigm . Rather, most of the decidual macrophages display a unique, M2‐like phenotype throughout pregnancy . Decidual macrophages from women who underwent spontaneous labor at term or preterm labor, however, exhibit an M1‐like pro‐inflammatory phenotype .…”

Section: Introductionmentioning

confidence: 99%

The immunophenotype of decidual macrophages in acute atherosis

Gill

Leng

Romero

et al. 2019

American J Rep Immunol

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Problem: Acute atherosis is a uteroplacental arterial lesion that is associated with pregnancy complications such as preeclampsia and preterm birth, the latter being the leading cause of perinatal morbidity and mortality worldwide. However, the immunobiology of acute atherosis is poorly understood. Method of study:Placental basal plate samples were collected from women who delivered with (n = 11) and without (n = 31) decidua basalis lesions of acute atherosis.Multicolor flow cytometry was used to quantify M1-and M2-like macrophage subsets and the expression of iNOS and IL-12 by decidual macrophages. Multiplex fluorescence staining and phenoptics were performed to localize M1-, MOX-, and Mhem-like macrophages in the decidual basalis. Results:Macrophages displayed diverse phenotypes in the decidua basalis with acute atherosis. M2-like macrophages were the most abundant subset in the decidua; yet, this macrophage subset did not change with the presence of acute atherosis. Decidual M1-like macrophages were increased in acute atherosis, and such macrophages displayed a pro-inflammatory phenotype, as indicated by the expression of iNOS and IL-12. Decidual M1-like pro-inflammatory macrophages were localized near both transformed and non-transformed vessels in the decidua basalis with acute atherosis.

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IL‐33/ST2 axis affects the polarization and efferocytosis of decidual macrophages in early pregnancy

Abstract: This study indicates that IL-33 secreted by dMφs promotes M2 bias at the feto-maternal interface, and as a result, RSA might attribute to the disturbance of IL-33/ST2 axis and the enhancement of efferocytosis of dMφs subsequently.

Cited by 31 publications

References 32 publications

Macrophage Polarization in Physiological and Pathological Pregnancy

Macrophage Polarization in Physiological and Pathological Pregnancy

Dynamic Function and Composition Changes of Immune Cells During Normal and Pathological Pregnancy at the Maternal-Fetal Interface

The immunophenotype of decidual macrophages in acute atherosis

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