2023
DOI: 10.1111/odi.14479
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KDM4D enhances osteo/dentinogenic differentiation and migration of SCAPs via binding to RPS5

Abstract: ObjectivesStem cells of the apical papilla (SCAPs) provide promising candidates for dental pulp regeneration. Despite great advances in the transcriptional controls of the SCAPs fate, little is known about the regulation of SCAP differentiation.Materials and MethodsShort hairpin RNAs and full‐length RNA were used to deplete or overexpress lysine demethylase 4D (KDM4D) gene expression. Western blotting, real‐time RT‐PCR, alizarin red staining, and scratch migration assays were used to study the role of KDM4D an… Show more

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