<scp>LMNB2</scp> is a prognostic biomarker and correlated with immune infiltrates in hepatocellular carcinoma

Kong, Weihao; Wu, Zihao; Yang, Mingwei; Zuo, Xiaomin; Yin, Guanfu; Chen, Wei

doi:10.1002/iub.2408

Cited by 15 publications

(11 citation statements)

References 22 publications

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“…In order to explore the relationship between immune-infiltration level and the two immune genes, we used CIBERSORT (Chen et al, 2018;Kong et al, 2020;Meng et al, 2021a) (https:// cibersort.stanford.edu/) to obtain the immune infiltration level of TCGA-KIRC data. The algorithm was run using LM22 signature and 1,000 permutations.…”

Section: Immune Infiltration Analysis Of Vav3 and Nr3c2mentioning

confidence: 99%

A Novel Immune-Related ceRNA Network and Relative Potential Therapeutic Drug Prediction in ccRCC

Meng

et al. 2022

Front. Genet.

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Renal cell carcinoma (RCC) is the third common solid tumor in the urinary system with a high distant metastasis rate. The five-year survival rate of RCC has reached 75%, benefiting from the emergence and update of multiple treatments, while its pathogenesis and prognostic markers are still unclear. In this study, we committed to explore a prognostic ceRNA network that could participate in the development of RCC and had not been studied yet. We screened nine immune-related hub genes (AGER, HAMP, LAT, LTB4R, NR3C2, SEMA3D, SEMA3G, SLC11A1, and VAV3) using data of The Cancer Genome Atlas Kidney Clear Cell Carcinoma database (TCGA-KIRC) through survival analysis and the cox proportional hazard model. Next, we successfully constructed a ceRNA network of two mRNA (NR3C2 and VAV3), miRNA (hsa-miR-186-5p), and lncRNA (NNT-AS1) for ccRCC based on numerous online bioinformatics tools and Cytoscape. Finally, we predicted five potential drugs (clemizole, pentolonium, dioxybenzone, Prestwick-691, and metoprolol) based on the above results.

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Section: Immune Infiltration Analysis Of Vav3 and Nr3c2mentioning

confidence: 99%

A Novel Immune-Related ceRNA Network and Relative Potential Therapeutic Drug Prediction in ccRCC

Meng

et al. 2022

Front. Genet.

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“…In the future, whether LMNB2 regulated bladder cancer progression via regulating mitochondrial function will be studied. It has also been widely reported that LMNB2 affects the progression and metastasis of multiple types of cancers (15,16). LMNB2 was also aberrantly highly expressed in several cancer tissues, including liver and lung cancer (15,16).…”

Section: Discussionmentioning

confidence: 94%

“…Notably, LMNB2 is recognized as an oncogene affecting the progression of multiple types of cancers, such as ovarian, lung, and liver cancer (13)(14)(15). LMNB2 was revealed to be aberrantly highly expressed in tumor tissues, and correlated with the prognosis of several cancers, such as breast, liver, and lung cancer (15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

Lamin B2 contributes to the proliferation of bladder cancer cells via activating the expression of cell division cycle‑associated protein 3

Chen

et al. 2022

Int J Mol Med

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Bladder cancer is the most common malignant tumor of the urinary system, and in China it is first among urogenital system tumors. More therapeutic targets are still urgently required to combat this disease. Lamin B2 (LMNB2) is a type of nuclear lamina filament protein, which is involved in multiple cellular processes, and known as an oncogene affecting the progression of multiple types of cancers. Although the multiple effects of LMNB2 on cancer progression have been elucidated, its possible role in bladder cancer remains unclear. In the present study, it was determined that LMNB2 expression was upregulated in human bladder cancer tissues, and its expression was correlated with the prognosis and the clinical features, including tumor stage (P=0.001) and recurrence (P= 0.006) of patients with bladder cancer. In addition, it was further revealed that LMNB2 depletion inhibited bladder cancer cell proliferation, stimulated cell cycle arrest and apoptosis in vitro, and suppressed tumor growth of bladder cancer cells in mice. Furthermore, the present data revealed that LMNB2 promoted the proliferation of bladder cancer cells via transcriptional activation of CDCA3 expression. Therefore, the role of LMNB2 in bladder cancer progression was demonstrated, and may serve as a promising therapeutic target for bladder cancer treatment.

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“…There is no experimental evidence that LMNB2, BGN, and MFSD12 in this combination are associated with GA, and these are new PmBs identified in this study. LMNB2 belongs to the lamin family and is closely related to occurrence, development, and prognosis of liver cancer (Kong et al, 2020;Li X. N. et al, 2020). BGN is an important member of the leucinerich small proteoglycan family and an important component of the extracellular matrix.…”

Section: Discussionmentioning

confidence: 99%

mRBioM: An Algorithm for the Identification of Potential mRNA Biomarkers From Complete Transcriptomic Profiles of Gastric Adenocarcinoma

Dong

Rao

et al. 2021

Front. Genet.

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PurposeIn this work, an algorithm named mRBioM was developed for the identification of potential mRNA biomarkers (PmBs) from complete transcriptomic RNA profiles of gastric adenocarcinoma (GA).MethodsmRBioM initially extracts differentially expressed (DE) RNAs (mRNAs, miRNAs, and lncRNAs). Next, mRBioM calculates the total information amount of each DE mRNA based on the coexpression network, including three types of RNAs and the protein-protein interaction network encoded by DE mRNAs. Finally, PmBs were identified according to the variation trend of total information amount of all DE mRNAs. Four PmB-based classifiers without learning and with learning were designed to discriminate the sample types to confirm the reliability of PmBs identified by mRBioM. PmB-based survival analysis was performed. Finally, three other cancer datasets were used to confirm the generalization ability of mRBioM.ResultsmRBioM identified 55 PmBs (41 upregulated and 14 downregulated) related to GA. The list included thirteen PmBs that have been verified as biomarkers or potential therapeutic targets of gastric cancer, and some PmBs were newly identified. Most PmBs were primarily enriched in the pathways closely related to the occurrence and development of gastric cancer. Cancer-related factors without learning achieved sensitivity, specificity, and accuracy of 0.90, 1, and 0.90, respectively, in the classification of the GA and control samples. Average accuracy, sensitivity, and specificity of the three classifiers with machine learning ranged within 0.94–0.98, 0.94–0.97, and 0.97–1, respectively. The prognostic risk score model constructed by 4 PmBs was able to correctly and significantly (∗∗∗p < 0.001) classify 269 GA patients into the high-risk (n = 134) and low-risk (n = 135) groups. GA equivalent classification performance was achieved using the complete transcriptomic RNA profiles of colon adenocarcinoma, lung adenocarcinoma, and hepatocellular carcinoma using PmBs identified by mRBioM.ConclusionsGA-related PmBs have high specificity and sensitivity and strong prognostic risk prediction. MRBioM has also good generalization. These PmBs may have good application prospects for early diagnosis of GA and may help to elucidate the mechanism governing the occurrence and development of GA. Additionally, mRBioM is expected to be applied for the identification of other cancer-related biomarkers.

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LMNB2 is a prognostic biomarker and correlated with immune infiltrates in hepatocellular carcinoma

Cited by 15 publications

References 22 publications

A Novel Immune-Related ceRNA Network and Relative Potential Therapeutic Drug Prediction in ccRCC

A Novel Immune-Related ceRNA Network and Relative Potential Therapeutic Drug Prediction in ccRCC

Lamin B2 contributes to the proliferation of bladder cancer cells via activating the expression of cell division cycle‑associated protein 3

mRBioM: An Algorithm for the Identification of Potential mRNA Biomarkers From Complete Transcriptomic Profiles of Gastric Adenocarcinoma

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