MG53: A potential therapeutic target for kidney disease

Abstract

Ensuring cell survival and tissue regeneration by maintaining cellular integrity is important to the pathophysiology of many human diseases, including kidney disease. Mitsugumin 53 (MG53) is a member of the tripartite motif‐containing (TRIM) protein family that plays an essential role in repairing cell membrane injury and improving tissue regeneration. In recent years, an increasing number of studies have demonstrated that MG53 plays a renoprotective role in kidney diseases. Moreover, with the beneficial effects of the recombinant human MG53 (rhMG53) protein in the treatment of kidney diseases in different animal models, rhMG53 shows significant therapeutic potential in kidney disease. In this review, we elucidate the role of MG53 and its molecular mechanism in kidney disease to provide new approaches to the treatment of kidney disease.

MG53 alleviates airway inflammatory responses by regulating nuclear factor-κB pathway in asthmatic mice

“…7 It has been documented that MG53 has a protective effect against the pathogenesis of multiple inflammatory diseases. 8,9 MG53 predominantly contributes to cardioprotection in cardiac diseases through regulating several cell signaling pathways, such as phosphatidylinositol 3-kinase-protein kinase B (PI3K) and extracellular signal-regulated kinase 1 and 2 (ERK1/2) signaling pathways. 28 Moreover, accumulating evidence showed that systemic cell infiltration and mucus secretion were aggravated in lung tissues but were attenuated by MG53 intervention (Figures 2B and 2C).…”

“…7 Recently, more studies have shown that MG53 acts as a protective agent in the kidney and cardiac diseases. 8,9 In addition, a wide range of human diseases, such as diabetes mellitus and lung cancer, are regulated by MG53. Further, studies have documented that MG53 is involved in a variety of physiological and pathological processes, such as the suppression of aberrant intracellular Ca 2+ signaling, insulin resistance, inhibition of inflammation, suppression of cell apoptosis, reduction of oxidative stress, and wound healing.…”