<scp>Microbiome‐metabolomic</scp> analyses of the impacts of dietary stachyose on fecal microbiota and metabolites in infants intestinal microbiota‐associated mice

Xi, Menglu; Tang, Hong; Zhang, Yan; Ge, Wupeng; Chen, Ying; Cui, Xiuxiu

doi:10.1002/jsfa.10963

Cited by 8 publications

(6 citation statements)

References 35 publications

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“…41 In animal models, stachyose has been associated with changes in the intestinal microbiome composition, a decreased inflammation of the intestine and an increased mucosal barrier function. [41][42][43][44][45] Stachyose has also been found to upregulate the production of the metabolite taurocholic acid, downregulate amino acid metabolism and significantly regulate the metabolism of taurine and hydroxytaurine, pantothenate and coenzyme A biosynthesis, as well as other signaling pathways. 45 It seems to be growth-promoting for Bifidobacteria.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Bacille Calmette-Guérin Vaccination on the Composition of the Intestinal Microbiome in Neonates From the MIS BAIR Trial

Zimmermann,

Pittet,

Jakob

et al. 2023

Pediatric Infectious Disease Journal

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Introduction: The early-life intestinal microbiome plays an important role in the development and regulation of the immune system. It is unknown whether the administration of vaccines influences the composition of the intestinal microbiome. Objective: To investigate whether Bacille Calmette-Guérin (BCG) vaccine given in the first few days of life influences the abundance of bacterial taxa and metabolic pathways in the intestinal microbiome at 1 week of age. Methods: Healthy, term-born neonates were randomized at birth to receive BCG or no vaccine within the first few days of life. Stool samples were collected at 1 week of age from 335 neonates and analyzed using shotgun metagenomic sequencing and functional analyses. Results: The composition of the intestinal microbiome was different between neonates born by cesarean section (CS) and those born vaginally. Differences in the composition between BCG-vaccinated and BCG-naïve neonates were only minimal. CS-born BCG-vaccinated neonates had a higher abundance of Staphylococcus lugdunensis compared with CS-born BCG-naïve neonates. The latter had a higher abundance of Streptococcus infantis and Trabulsiella guamensis. Vaginally-born BCG-vaccinated neonates had a higher abundance of Clostridiaceae and Streptococcus parasanguinis compared with vaginally-born BCG-naïve neonates, and a lower abundance of Veillonella atypica and Butyricimonas faecalis. Metabolic pathways that were differently abundant between BCG-vaccinated and BCG-naïve neonates were mainly those involved in sugar degradation and nucleotide/nucleoside biosynthesis. Conclusion: BCG given in the first few days of life has little effect on the composition of the intestinal microbiome at 1 week of age but does influence the abundance of certain metabolic pathways.

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Section: Discussionmentioning

confidence: 99%

The Effect of Bacille Calmette-Guérin Vaccination on the Composition of the Intestinal Microbiome in Neonates From the MIS BAIR Trial

Zimmermann,

Pittet,

Jakob

et al. 2023

Pediatric Infectious Disease Journal

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“…The study showed that stachyose significantly altered the intestinal microbiota and metabolitescomposition, and increased the relative abundance of Verrucomicrobia, Actinobacteria, Akkermansia, and Bifidobacterium. [ 29 ] Other studies also show that stachyose promotes the growth of beneficial intestinal bacteria, inhibits pathogenic bacteria, and improves health outcomes in diabetes. [ 30 ]…”

Section: Discussionmentioning

confidence: 99%

In Vitro Effects of Stachyose on the Human Gut Microbiota

Zhao

Liu

2021

Starch Stärke

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Gut microbiota plays an important role in human health. Stachyose, an oligosaccharide, modulates the gut microbiota composition in animals. However, the role of stachyose in promoting the proliferation of probiotics and whether it inhibits pathogenic micro‐organisms in human gut microbiota has not been explored. Therefore, in this study, the effects of stachyose on the gut microbiota and its metabolites in humans are explored. Three concentrations of stachyose are used as the sole carbon source for in vitro fermentation. Results show that stachyose improves beta diversity and increases the concentration of short‐chain fatty acid (SCFAs), mainly acetic acid and butyric acid. Stachyose is found to promote the relative abundance of Bifidobacteria, Faecalibacterium, Lactobacillus, and Prevotella genera in the gut microbiota. Besides, stachyose significantly reduces the relative abundance of Bacteroides and Escherichia‐Shigella genera. The findings show that stachyose increases beneficial microbiota, therefore, it is a useful prebiotic which modulates the composition of the gut microbiota.

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“…These model systems present a powerful framework for integrating hypothesis testing into metabolomics studies of the microbiome and have been used to investigate diverse biological processes including aging 104 , reproduction 105,106 , and metabolism 13,14,16,107,108 . This strategy has been very successful in providing molecular insights into diverse diseases including colitis (both IBS and Crohn's disease) 15,17 , neurodegenerative disease 20,21 , breast cancer 32 , diabetes 109 , the biological response to toxin exposure 9,10,34,[110][111][112][113] , and the role that the microbiome plays in immunity 30,114 .…”

Section: Animal Model Strategies For Investigating Molecular Interact...mentioning

confidence: 99%

Moving beyond descriptive studies: harnessing metabolomics to elucidate the molecular mechanisms underpinning host-microbiome phenotypes

et al. 2022

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Advances in technology and software have radically expanded the scope of metabolomics studies and allow us to monitor a broad transect of central carbon metabolism in routine studies. These increasingly sophisticated tools have shown that many human diseases are modulated by microbial metabolism. Despite this, it remains surprisingly difficult to move beyond these statistical associations and identify the specific molecular mechanisms that link dysbiosis to the progression of human disease. This difficulty stems from both the biological intricacies of host-microbiome dynamics as well as the analytical complexities inherent to microbiome metabolism research. The primary objective of this review is to examine the experimental and computational tools that can provide insights into the molecular mechanisms at work in host-microbiome interactions and to highlight the undeveloped frontiers that are currently holding back microbiome research from fully leveraging the benefits of modern metabolomics.

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Microbiome‐metabolomic analyses of the impacts of dietary stachyose on fecal microbiota and metabolites in infants intestinal microbiota‐associated mice

Cited by 8 publications

References 35 publications

The Effect of Bacille Calmette-Guérin Vaccination on the Composition of the Intestinal Microbiome in Neonates From the MIS BAIR Trial

The Effect of Bacille Calmette-Guérin Vaccination on the Composition of the Intestinal Microbiome in Neonates From the MIS BAIR Trial

In Vitro Effects of Stachyose on the Human Gut Microbiota

Moving beyond descriptive studies: harnessing metabolomics to elucidate the molecular mechanisms underpinning host-microbiome phenotypes

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