<scp>Oligomer‐A<i>β</i>42</scp> suppress glioma progression via potentiating phagocytosis of microglia

Lu, Jie; Wang, Zhenning; He, Zhenqiang; Hu, Yang; Duan, Hao; Liu, Zihao; Li, Depei; Zhong, Sheng; Ren, Jiaoyan; Zhao, Guojun; Mou, Yonggao; Yao, Maojin

doi:10.1111/cns.14495

Cited by 2 publications

(1 citation statement)

References 57 publications

(113 reference statements)

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“…Furthermore, it was demonstrated that BACE-1 is expressed in tumor promoting macrophages and administration of MK-8931 along with IR was able to suppress malignant GBM growth in-vivo. Interestingly, oligomers of beta amyloid protein that are associated with AD can stimulate microglia phagocytotic activity against glioma cells [119]. As with many neurodegenerative disorders, microglia dysfunction seems to be a central feature of both gliomagenesis and AD [120].…”

Section: Bace-1mentioning

confidence: 99%

Phagocytosis Checkpoints in Glioblastoma: CD47 and Beyond

Afzal,

Bizink

et al. 2024

Preprint

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Glioblastoma multiforme (GBM) is one of the deadliest human cancers with very lim-ited treatment options available. The malignant behavior of GBM is manifest in a tu-mor which is highly invasive, resistant to standard cytotoxic chemotherapy and is strongly immunosuppressive. Immune checkpoint inhibitors have recently been in-troduced in the clinic and have yielded promising results in certain cancers. GBM however is largely refractory to these treatments. The immune checkpoint CD47 has recently gained attention as potential target for intervention as it conveys a “don’t eat me” signal to tumor associated macrophages via the inhibitory SIRP alpha protein. In preclinical models, administration of anti-CD47 monoclonal antibodies have shown impressive results with GBM and other tumor models. Several well characterized on-cogenic pathways have recently been shown to regulate CD47 expression in GBM cells and Glioma Stem cells (GSCs) include EGFR, beta catenin and LRIG2. Other macro-phage pathways involved in regulating phagocytosis including TREM2 and glycan binding proteins are discussed as well. Finally, Chimeric Antigen Receptor Macro-phages (CAR)-M could be leveraged for greatly enhancing phagocytosis of GBM and repolarization of the microenvironment in general. Here we comprehensively review the mechanisms that regulate about macrophage phagocytosis of GBM cells.

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Section: Bace-1mentioning

confidence: 99%

Phagocytosis Checkpoints in Glioblastoma: CD47 and Beyond

Afzal,

Bizink

et al. 2024

Preprint

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Phagocytosis Checkpoints in Glioblastoma: CD47 and Beyond

Afzal,

Bizink

et al. 2024

CIMB

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Glioblastoma multiforme (GBM) is one of the deadliest human cancers with very limited treatment options available. The malignant behavior of GBM is manifested in a tumor which is highly invasive, resistant to standard cytotoxic chemotherapy, and strongly immunosuppressive. Immune checkpoint inhibitors have recently been introduced in the clinic and have yielded promising results in certain cancers. GBM, however, is largely refractory to these treatments. The immune checkpoint CD47 has recently gained attention as a potential target for intervention as it conveys a “don’t eat me” signal to tumor-associated macrophages (TAMs) via the inhibitory SIRP alpha protein. In preclinical models, the administration of anti-CD47 monoclonal antibodies has shown impressive results with GBM and other tumor models. Several well-characterized oncogenic pathways have recently been shown to regulate CD47 expression in GBM cells and glioma stem cells (GSCs) including Epidermal Growth Factor Receptor (EGFR) beta catenin. Other macrophage pathways involved in regulating phagocytosis including TREM2 and glycan binding proteins are discussed as well. Finally, chimeric antigen receptor macrophages (CAR-Ms) could be leveraged for greatly enhancing the phagocytosis of GBM and repolarization of the microenvironment in general. Here, we comprehensively review the mechanisms that regulate the macrophage phagocytosis of GBM cells.

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Oligomer‐Aβ42 suppress glioma progression via potentiating phagocytosis of microglia

Cited by 2 publications

References 57 publications

Phagocytosis Checkpoints in Glioblastoma: CD47 and Beyond

Phagocytosis Checkpoints in Glioblastoma: CD47 and Beyond

Phagocytosis Checkpoints in Glioblastoma: CD47 and Beyond

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