PEG‐PLA‐PCL based electrospun yarns with curcumin control release property as suture

Abstract

This work presents an interesting method using an electrospinning process to fabricate suture yarns loaded with curcumin to achieve reasonable mechanical properties as well as tunable drug release behavior. Different structures including different yarn counts and twists as well as core‐sheath structures were used to adjust drug release properties along with improving the yarn's mechanical properties. The core parts were made of polycaprolactone and the sheath parts were made of polyethylene glycol, polylactic acid, and polycaprolactone. Drugs can be incorporated in both parts based on the required condition and application. Electrospun yarns were compared using both structural properties and their drug release profiles as metrics. The results of comparing drug release profiles of six electrospun yarns with different yarn counts and twists showed that yarns with finer fiber diameters in the core part have more drug release as well as more initial release. Overall evaluations showed that core‐sheath drugloaded yarn with appropriate physical and mechanical properties can be a useful material as a drug delivery system to the site of damaged tissue. It can also be concluded that the amount and duration of drug release can be controlled using the structural parameters of electrospun yarns as an engineering tool for designing suture yarns with required properties.

Lycopene loaded polylactic acid (PLA) and PLA/copolymer electrospun nanofibers, synthesis, characterization, and control release

“…This kind of release was also observed when EE of PEO‐containing fibers was measured. Recent studies on the release control of encapsulated compounds within PLA nanofibers with the help of different copolymers are similar to the results obtained in this study (Herrero‐Herrero et al., 2018; Sharifisamani et al., 2020).…”

Electrospun progesterone‐loaded cellulose acetate nanofibers and their drug sustained‐release profiles

“…Besides, high drug loading ability, permeability and flexibility, exclusive surface topology, biomimetic properties, controllable morphology, distinct and abundant raw materials, suitable adhesion, and controlled mechanical properties also make these nanostructured materials quite interesting for drug-delivery applications. [1][2][3]10,[14][15][16][17][18][19] Polymeric nanofibers have been applied as DDS for delivery of antibiotic, [5,20] antimicrobial agents, [15,21] vitamins, [22] antiinflammatory, [23] analgesic, [2] antidepressant, [24] anticancer, [3] antimycotic [25] and anthelmintic, [14] as well as hormones. [8,10,17] Desirable release profile (ie, immediate, sustained, biphasic, or delayed) from drug-loaded polymeric nanofibers could be easily achieved by the choice of the polymer/solvent system and nanofiber fabrication method.…”

New Strategies for the Development of Multifunctional Suture Threads

“…[ 2 ] Sharifisamani et al. [ 15 ] reported the electrospinning process to fabricate the suture threads loaded with curcumin. The sutures had a core part composed by polycaprolactone (PCL) and a drug‐loaded sheath part consisting of polyethylene glycol/polylactic acid/polycaprolactone (PEG‐PLA‐PCL).…”