<scp>Phosphorylation‐mediated PI3K‐Art</scp> signalling pathway as a therapeutic mechanism in the <scp>hydrogen‐induced</scp> alleviation of brain injury in septic mice

Bai, Yuanyuan; Li, Li; Dong, Beibei; Ma, Wanjie; Chen, Hongguang; Yu, Yonghao

doi:10.1111/jcmm.17568

Cited by 7 publications

(2 citation statements)

References 39 publications

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“…Modern studies have shown that there is a link between Th, Scg2, Rpl17, Chl1, Alb and AD [ 15 - 19 ], SPP1, Th, Prex2 play a role in a variety of diseases by regulating the PI3K-AKT signaling pathway [ 20 - 23 ]. In the transcriptome sequencing, the KEGG enrichment analysis of differentially expressed genes was significantly enriched in the PI3K-AKT signaling pathway.…”

Section: Resultsmentioning

confidence: 99%

Analysis of the mechanism of fibrauretine alleviating Alzheimer's disease based on transcriptomics and proteomics

Han,

Chen,

Zong

et al. 2024

Korean J Physiol Pharmacol

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Section: Resultsmentioning

confidence: 99%

Analysis of the mechanism of fibrauretine alleviating Alzheimer's disease based on transcriptomics and proteomics

Han,

Chen,

Zong

et al. 2024

Korean J Physiol Pharmacol

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“…Further analysis showed changes in protein phosphorylation in the H 2 -treated group, especially in the case of serine, which regulates cell functions. The authors postulated that the PI3K/Akt signaling pathway mediated this process [ 55 ].…”

Section: Hydrogenmentioning

confidence: 99%

Exploring Neuroprotective Agents for Sepsis-Associated Encephalopathy: A Comprehensive Review

Krzyzaniak,

Krion,

Szymczyk

et al. 2023

IJMS

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Sepsis is a life-threatening condition resulting from an inflammatory overreaction that is induced by an infectious factor, which leads to multi-organ failure. Sepsis-associated encephalopathy (SAE) is a common complication of sepsis that can lead to acute cognitive and consciousness disorders, and no strict diagnostic criteria have been created for the complication thus far. The etiopathology of SAE is not fully understood, but plausible mechanisms include neuroinflammation, blood–brain barrier disruption, altered cerebral microcirculation, alterations in neurotransmission, changes in calcium homeostasis, and oxidative stress. SAE may also lead to long-term consequences such as dementia and post-traumatic stress disorder. This review aims to provide a comprehensive summary of substances with neuroprotective properties that have the potential to offer neuroprotection in the treatment of SAE. An extensive literature search was conducted, extracting 71 articles that cover a range of substances, including plant-derived drugs, peptides, monoclonal antibodies, and other commonly used drugs. This review may provide valuable insights for clinicians and researchers working in the field of sepsis and SAE and contribute to the development of new treatment options for this challenging condition.

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Effects of the PI3K/Akt/HO-1 pathway on autophagy in a sepsis-induced acute lung injury mouse model

Tian,

Li,

Mao

et al. 2023

International Immunopharmacology

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Phosphorylation‐mediated PI3K‐Art signalling pathway as a therapeutic mechanism in the hydrogen‐induced alleviation of brain injury in septic mice

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 7 publications

References 39 publications

Analysis of the mechanism of fibrauretine alleviating Alzheimer's disease based on transcriptomics and proteomics

Analysis of the mechanism of fibrauretine alleviating Alzheimer's disease based on transcriptomics and proteomics

Exploring Neuroprotective Agents for Sepsis-Associated Encephalopathy: A Comprehensive Review

Effects of the PI3K/Akt/HO-1 pathway on autophagy in a sepsis-induced acute lung injury mouse model

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