Severe bacterial infections (SBI), that is, meningitis, pneumonia, pyelonephritis, gastroenteritis, osteomyelitis, cellulitis/abscess and sepsis, are associated with worldwide high mortality and childhood morbidity rates. [1][2][3][4] In Italy, SBIs are responsible for 1.7% of infant mortality under 5 years of age. 5 In Europe, the incidence of severe infections observed at primary care services in children aged