<scp><sup>31</sup>P‐MRS</scp> in Migraine: Fallen Through the Cracks

Paemeleire, Koen; Schoenen, Jean

doi:10.1111/head.12049

Cited by 8 publications

(9 citation statements)

References 9 publications

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“…For instance, clinical observations of migraine precursors and current published electrophysiological research propose that cortical information processing might change at the time of an attack. The normalization of cortical responses before and during an attack might reflect increased cortical preactivation levels as a result of increased activity in raphe-cortical serotonergic pathways (Judit et al, 2010) and metabolic factors (Paemeleire and Schoenen, 2013); the biological rhythms of hypothalamic activity (Maniyar et al, 2014); or the actual trigger of attacks may be the functional variation in hypothalamic-brainstem connections (Schulte and May, 2016); or periodicity of brain activity in neurophysiology may be related to psychophysiology, genetic (SÃndor et al, 1999;Siniatchkin et al, 2001); Moreover, psychophysiological pathways have become the basis of migraine research. Through the study of ERP, the results show that patients suffering from migraine without aura between attacks display a higher level of arousal and more superficial attention, but require more time for automatic and/or voluntary processes (Wang et al, 1995).…”

Section: Discussionmentioning

confidence: 99%

Contingent negative variation for the periodicity of migraine attacks without aura

Tian

Guo

et al. 2019

J. Integr. Neurosci.

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Migraine is a primary neuropsychological disorder, although its etiology and pathogenesis are unknown. It has been reported that using contingent negative variation, the periodicity of migraine attacks is three days in adults. However, there is still a lack of relevant reports about the periodicity of migraine without aura in adults. Therefore, we investigated the changes of contingent negative variation in adults with migraine without aura from three to seven days after migraine attacks in order to provide the basis for exploring the circulation periodicity of migraine without aura. This prospective, observational study involved a group of 34 individuals with migraine without aura, who were screened during the three to seven days after a migraine attack without aura. A healthy group (31 individuals) was used as controls to assess the amplitudes of contingent negative variation and habituation of early contingent negative variation. Indices of the amplitudes included overall contingent negative variation, initial contingent negative variation, terminal contingent negative variation, and postoperative negative contingent variation. Differences between these indicators were analyzed. No significant difference was found between the patient and control groups for either the amplitudes of these measures of contingent negative variation or habituation of the early contingent negative variation for three to seven days after a migraine attack without aura (all P > 0.05). Thus, the study reported here found that the periodicity of migraine attacks without aura in adults is more than three days.

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Section: Discussionmentioning

confidence: 99%

Contingent negative variation for the periodicity of migraine attacks without aura

Tian

Guo

et al. 2019

J. Integr. Neurosci.

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“…The occurrence of a metabolic strain in the cortex is a plausible hypothesis for igniting a migraine attack [ 23 ]. The cornerstone of the metabolic strain model is the unbalanced relationship between enhanced sensory processing and reduced metabolic offers [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

Evidence of an increased neuronal activation-to-resting glucose uptake ratio in the visual cortex of migraine patients: a study comparing 18FDG-PET and visual evoked potentials

et al. 2018

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BackgroundMigraine attacks might be triggered by a disruption of cerebral homeostasis. During the interictal period migraine patients are characterized by abnormal sensory information processing, but this functional abnormality may not be sufficient to disrupt the physiological equilibrium of the cortex unless it is accompanied by additional pathological mechanisms, like a reduction in energetic reserves. The aim of this study was to compare resting cerebral glucose uptake (using positron emission tomography (18fluorodeoxyglucose-PET)), and visual cortex activation (using visual evoked potentials (VEP)), between episodic migraine without aura patients in the interictal period and healthy volunteers.MethodsTwenty episodic migraine without aura patients and twenty healthy volunteers were studied. 18FDG-PET and VEP recordings were performed on separate days. The overall glucose uptake in the visual cortex-to-VEP response ratio was calculated and compared between the groups. Additionally, PET scan comparisons adding area under the VEP curve as a covariate were performed. For case-wise analysis, eigenvalues from a specific region exhibiting significantly different FDG-PET signal in the visual cortex were extracted. Standardized glucose uptake values from this region and VEP values from each subject were then coupled and compared between the groups.ResultsThe mean area under the curve of VEP was greater in migraine patients compared to healthy controls. In the same line, patients had an increased neuronal activation-to-resting glucose uptake ratio in the visual cortex. Statistical parametric mapping analysis revealed that cortical FDG-PET signal in relation to VEP area under the curve was significantly reduced in migraineurs in a cluster extending throughout the left visual cortex, from Brodmann’s areas 19 and 18 to area 7. Within this region, case-wise analyses showed that a visual neuronal activation exceeding glucose uptake was present in 90% of migraine patients, but in only 15% of healthy volunteers.ConclusionThis study identifies an area of increased neuronal activation-to-resting glucose uptake ratio in the visual cortex of migraine patients between attacks. Such observation supports the concept that an activity-induced rupture of cerebral metabolic homeostasis may be a cornerstone of migraine pathophysiology.This article has been selected as the winner of the 2018 Enrico Greppi Award. The Enrico Greppi Award is made to an unpublished paper dealing with clinical, epidemiological, genetic, pathophysiological or therapeutic aspects of headache. Italian Society for the Study of Headaches (SISC) sponsors this award, and the award is supported through an educational grant from Teva Neuroscience. This article did not undergo the standard peer review process for The Journal of Headache and Pain. The members of the 2018 Enrico Greppi Award Selection Committee were: Francesco Pierelli, Paolo Martelletti, Lyn Griffiths, Simona Sacco, Andreas Straube and Cenk Ayata.

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“…For instance, cortical responsivity is cyclic in individuals with migraine, 71 and varies in parallel with changes in platelet serotonin content. 73 The period icity of neurophysiological brain activity might also be related to psychophysical, genetic 66,79 or metabolic factors, 80 or to the biorhythms of hypothalamic activity. 81 Migraine periodicity might thus be the result of several inter acting biological cycles.…”

Section: Episodic Migrainementioning

confidence: 99%

“…However, the fact that the interictal cortical hyperrespons ivity to sensory stimuli in migraine can be alleviated by neuro stimulation techniques 55 (see below) and by preventive antimigraine drugs, both of which also decrease attack frequency, 107 supports indirectly the hypothesis that the brain dysfunction between attacks could predispose patients to recurrent attacks. Considering that the cer ebral energy reserve (ATP content) between attacks is sig nificantly lower in individuals with migraine compared with healthy individuals, 80 it is tempting to speculate that the cortical hyperresponsivity might contribute to dis ruption of the brain's metabolic homeostasis by increas ing energy demand, thereby initiating the biochemical cascade that leads to the migraine attack. 6 …”

Section: Thalamocortical Dysrhythmia In Migrainementioning

confidence: 99%

Altered processing of sensory stimuli in patients with migraine

et al. 2014

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| Migraine is a cyclic disorder, in which functional and morphological brain changes fluctuate over time, culminating periodically in an attack. In the migrainous brain, temporal processing of external stimuli and sequential recruitment of neuronal networks are often dysfunctional. These changes reflect complex CNS dysfunction patterns. Assessment of multimodal evoked potentials and nociceptive reflex responses can reveal altered patterns of the brain's electrophysiological activity, thereby aiding our understanding of the pathophysiology of migraine. In this Review, we summarize the most important findings on temporal processing of evoked and reflex responses in migraine. Considering these data, we propose that thalamocortical dysrhythmia may be responsible for the altered synchronicity in migraine. To test this hypothesis in future research, electrophysiological recordings should be combined with neuroimaging studies so that the temporal patterns of sensory processing in patients with migraine can be correlated with the accompanying anatomical and functional changes.

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³¹P‐MRS in Migraine: Fallen Through the Cracks

Cited by 8 publications

References 9 publications

Contingent negative variation for the periodicity of migraine attacks without aura

Contingent negative variation for the periodicity of migraine attacks without aura

Evidence of an increased neuronal activation-to-resting glucose uptake ratio in the visual cortex of migraine patients: a study comparing 18FDG-PET and visual evoked potentials

Altered processing of sensory stimuli in patients with migraine

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31P‐MRS in Migraine: Fallen Through the Cracks

Cited by 8 publications

References 9 publications

Contingent negative variation for the periodicity of migraine attacks without aura

Contingent negative variation for the periodicity of migraine attacks without aura

Evidence of an increased neuronal activation-to-resting glucose uptake ratio in the visual cortex of migraine patients: a study comparing 18FDG-PET and visual evoked potentials

Altered processing of sensory stimuli in patients with migraine

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³¹P‐MRS in Migraine: Fallen Through the Cracks