Thiol‐disulfide status of patients with cervical cancer

Abstract

Aim: The evaluation of dynamic thiol-disulfide homeostasis among patients with the cancer of the uterine cervix. Methods: The study was conducted in 62 cervical cancer patients and 61 healthy women who had been followed up in an obstetrics and gynecology clinic between September 2018 and April 2020. Serum disulfide, native thiol, total thiol, ischemia modified-albumin, total antioxidant and oxidant capacities, and oxidative stress index values were measured in all participants. Results: The mean plasma disulfide levels of the cervical cancer group was statistically significantly higher than that of the control group (25.79 AE 6.90 μmol/L, 22.31 AE 6.11 μmol/L, respectively) (P = 0.004). Plasma native thiol and total thiol levels were lower in cervical cancer patients (299.27 AE 99.05 μmol/L and 350.86 AE 102.72 μmol/L, respectively) compared to controls, but no statistically significant difference was observed (318.00 AE 93.75 μmol/L and 376.44 AE 98.51 μmol/L, respectively) (P = 0.284, P = 0.161). With respect to the ischemia modified-albumin level, no statistically significant difference was observed between two groups. There were statistically significant positive association between disulfide level and both the stage of cervical cancer (r = 0.278, P = 0.029) and total oxidant capacity level (r = 0.256, P = 0.046). Conclusion: Dynamic thiol-disulfide homeostasis may participate in the pathophysiological mechanisms of cervical cancer and may be a potential biomarker for early identification of cervical cancer in future.

Histological changes in methotrexate hepatotoxicity after boron application and evaluation of serum thiol-disulfide balance

“…In another word, thiol-disulfide homeostasis is reversible and in balance. This balance is disturbed in many illness situations (4,(25)(26)(27)(28). In our study, the decrease in native thiol level and increase in disulfide and % disulfide/ native thiol levels in MTX administired groups show that thiol-disulfide balance deteriorates in favor of oxidation (Table , Figure 3).…”

Disulfidptosis status influences prognosis and therapeutic response in clear cell renal cell carcinoma

“…Disulfidptosis, a novel form of cell death reported in 2023 by Liu et al, has attracted the attention of researchers worldwide [ 12 , 20 ]. A few research groups have elucidated that disulfidptosis plays an important role in various biological processes, such as homeostasis, may be involved in the development of tumors, and may potentially be used for the treatment of tumors [ 12 , 36 ]. Disulfidptosis represents a mode of cystine accumulation in SLC7A11 high cells subjected to glucose starvation and is distinct from other known types of PCDs.…”

Thiol-Disulfide Homeostasis in Skin Diseases

“…Based on these findings, elevated serum thiol levels may represent a mechanism for blocking free thiols in the HPV structure [ 44 ]. Changes in the thiol-disulfide balance have been detected in premalignant and malignant lesions caused by HPV [ 21 , 152 ]. Regarding warts, we identified two studies that evaluated TDH.…”