Thiol-Disulfide Homeostasis in Skin Diseases

Georgescu, Simona Roxana; Mitran, Cristina Iulia; Mitran, Mădălina Irina; Matei, Clara; Popa, G; Erel, Özcan; Tampa, Mircea

doi:10.3390/jcm11061507

Cited by 21 publications

(16 citation statements)

References 153 publications

(188 reference statements)

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“…Furthermore, oxidative stress is positively correlated with disease activity [ 17 ]. It is related to the fact that the skin harbors a wide range of enzymatic and nonenzymatic compounds that act as antioxidants or oxidant-degrading molecules [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

The Role of Oxidative Stress in Atopic Dermatitis and Chronic Urticaria

et al. 2022

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Atopic dermatitis (AD) and chronic urticaria (CU) are common skin diseases with an increasing prevalence and pathogenesis that are not fully understood. Emerging evidence suggests that oxidative stress plays a role in AD and CU. The aim of the single-center cross-sectional study was to compare markers of oxidative stress in 21 patients with AD, and 19 CU patients. The products of protein oxidation, total antioxidant capacity (TAC), and markers of lipid peroxidation were estimated in the serum. AD patients had a higher level of advanced protein oxidation products and a lower level of thiol groups than healthy participants. However, CU patients had statistically higher levels of AOPP and 3-nitrotyrosine than healthy subjects. The level of thiol groups and serum TAC decreased significantly in patients with CU. There was no difference in serum concentration of lipid peroxidation products, Amadori products, ratio of reduced to oxidized glutathione, and ability of albumin to binding cobalt between AD or CU patients compared to healthy subjects. We found a moderate positive significant correlation between AOPP and age in patients with AD. In patients with CU, TAC was negatively correlated with age. These results may shed light on the etiopathogenesis of AD or CU, and confirm an oxidative burden in these patients. Furthermore, our study could be useful in developing new therapeutic methods that include using antioxidants in dermatological diseases.

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Section: Introductionmentioning

confidence: 99%

The Role of Oxidative Stress in Atopic Dermatitis and Chronic Urticaria

et al. 2022

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“…ROS modulate important processes underlying the pathogenesis of urticaria such as mast cell degranulation, endothelial cell function and vascular permeability. Moreover, mast cell activation is influenced by ROS-dependent activation of protein kinase C [ 64 ].…”

Section: Discussionmentioning

confidence: 99%

Ischemia-Modified Albumin—A Potential New Marker of Oxidative Stress in Dermatological Diseases

Tampa

Mitran

et al. 2022

Medicina

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There is growing evidence that oxidative stress is involved in the pathogenesis of numerous conditions, including dermatological diseases. Various markers are available to assess oxidative stress, but none of these can be considered the ideal marker. Recent studies have shown that ischemia-modified albumin (IMA) is not only an indicator of ischemia, but also a marker of oxidative stress. We have conducted a narrative review to evaluate the role of IMA in dermatological diseases. We have identified 24 original articles that evaluated IMA in skin disorders (psoriasis, acne vulgaris, hidradenitis suppurativa, urticaria, vitiligo and Behcet’s disease) and hair disorders (alopecia areata, androgenetic alopecia and telogen effluvium). The results of the studies analyzed reveal that IMA may be considered a new marker of oxidative stress in dermatological diseases and offer new insights into the pathogenesis of these disorders and the theoretical basis for the development of new, effective, targeted therapies. To the best of our knowledge, this is the first review that gathers up data on the role of IMA in dermatological diseases.

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“…This may vary depending on the stage and severity of the disease, and the level of oxidative stress and antioxidant capacity. 10 In this study, the cut-off value for the native thiol level to predict mortality was determined using ROC analysis. The sensitivity of the native thiol level and the specificity of the disulfide level were 91.3% and 50%, respectively.…”

Section: Ethics Committee Approvalmentioning

confidence: 99%

Erken Evre Küçük Hücreli Dışı Akciğer Kanserli Hastalarda Tiyol-Disülfid Homeostazisin Prognoz Üzerine Etkisi

KAVAS¹,

BAYTEMİR²,

Alışık

et al. 2023

Online Türk Sağlık Bilimleri Dergisi

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The Effect of Thiol-Disulfide Homeostasis on Prognosis in Patients with Early Stage of NSCLC Objective: Lung cancer has a poor prognosis. Thiol groups which have high antioxidant capacity, turn to disulpide (DS) groups with biochemical reactions that neutralize different oxidant compounds. Thiol/Disulpide homeostasis (TDH) has significant effects on cell mechanisms, transcription and apoptosis. We present the role of prognosis of dynamic TDH in patients operated for NSCLC. Methods: The patients who operated for early stage with NSCLC prospectively analysedTDH tests were measured by the automated spectrophotometric method. Results: 77 patients patients, 61 volunteer controls participated in this study. Native thiol (NT) and total thiol (TT) levels were significantly lower in the patient group. SS/NT ratio which is the indicator of oxidative stress of TDH also reached statistical significance in the patients (p

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Thiol-Disulfide Homeostasis in Skin Diseases

Cited by 21 publications

References 153 publications

The Role of Oxidative Stress in Atopic Dermatitis and Chronic Urticaria

The Role of Oxidative Stress in Atopic Dermatitis and Chronic Urticaria

Ischemia-Modified Albumin—A Potential New Marker of Oxidative Stress in Dermatological Diseases

Erken Evre Küçük Hücreli Dışı Akciğer Kanserli Hastalarda Tiyol-Disülfid Homeostazisin Prognoz Üzerine Etkisi

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