“…21 Regarding MFC donor-site morbidity, Rodríguez-Vegas and Delgado-Serrano 22 reported a series of 25 patients wherein they had few transient donor-site complications, including suture intolerance, seroma, and numbness in the saphenous territory; no fracture, knee instability, or stiffness was reported. Moreover, Kazmers et al 23 performed a systematic review of 40 papers which showed that the knee donor site rate of complications was 0.8% for femoral fracture and 0.4% for persistent knee pain. As for a femoral fracture, potentially the most serious complication, two studies conducted by the same group have shown the following: first, that harvest of MFC flap sizes greater or equal than 9 cm results in significantly lower stiffness compared with the 3-cm flap while testing axial stability, however, the femur retains its axial stability even after harvest of large corticocancellous flaps from its medial aspect 24 ; on the other hand, Endara et al 25 showed that bone failure rates were 12.5, 12.5, 28.6, and 55.6% for control, 3-, 5-, and 7-cm MFC harvest size groups, respectively.…”