Screen-printed digital microfluidics combined with surface acoustic wave nebulization for hydrogen-deuterium exchange measurements

Monkkonen, Lucas; Edgar, J. Scott; Winters, Daniel; Heron, S.; Mackay, C. Logan; Masselon, Christophe; Stokes, Adam A.; Langridge‐Smith, Patrick R. R.; Goodlett, David R.

doi:10.1016/j.chroma.2015.12.048

Cited by 21 publications

(16 citation statements)

References 43 publications

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“…, using standing wave configurations). 146,147,148 One particular limitation of SAW MS compared to more established techniques such as electrospray ionization (ESI) is interfacing with upstream separation techniques, such as liquid chromatography (LC). Tveen-Jensen et al have recently successfully demonstrated the coupling the of LC with SAW MS (Fig.…”

Section: Saw-integrated Microfluidicsmentioning

confidence: 99%

Surface acoustic wave devices for chemical sensing and microfluidics: a review and perspective

et al. 2017

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Surface acoustic waves (SAWs), are electro-mechanical waves that form on the surface of piezoelectric crystals. Because they are easy to construct and operate, SAW devices have proven to be versatile and powerful platforms for either direct chemical sensing or for upstream microfluidic processing and sample preparation. This review summarizes recent advances in the development of SAW devices for chemical sensing and analysis. The use of SAW techniques for chemical detection in both gaseous and liquid media is discussed, as well as recent fabrication advances that are pointing the way for the next generation of SAW sensors. Similarly, applications and progress in using SAW devices as microfluidic platforms are covered, ranging from atomization and mixing to new approaches to lysing and cell adhesion studies. Finally, potential new directions and perspectives on the field as it moves forward are offered, with a specific focus on potential strategies for making SAW technologies for bioanalytical applications.

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Section: Saw-integrated Microfluidicsmentioning

confidence: 99%

Surface acoustic wave devices for chemical sensing and microfluidics: a review and perspective

et al. 2017

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“…Aerosol generation using surface acoustic waves (SAWs) on piezoelectric chip substrates was first demonstrated by Kurosawa et al in 1995 (Kurosawa et al, 1995a ). Since then, several promising fields of application for this technique were reported, including inhalation therapy (Qi et al, 2009 ; Rajapaksa et al, 2014 ), olfactory displays (Nakamoto et al, 2014 ), micro- and nanoparticle synthesis (Alvarez et al, 2008 ; Kim et al, 2005 ; Qi et al, 2011 ), thin film deposition (Murochi et al, 2007 ; Darmawan et al, 2014 ; Winkler et al, 2016a ) and mass spectroscopy of low- or non-volatile fluids (Ho et al, 2011 ; Huang et al, 2012 ; Monkkonen et al, 2016 ; Winkler et al, 2016b ).…”

Section: Introductionmentioning

confidence: 99%

Compact SAW aerosol generator

Winkler

Harazim

Collins

et al. 2017

Biomed Microdevices

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In this work, we discuss and demonstrate the principle features of surface acoustic wave (SAW) aerosol generation, based on the properties of the fluid supply, the acoustic wave field and the acoustowetting phenomena. Furthermore, we demonstrate a compact SAW-based aerosol generator amenable to mass production fabricated using simple techniques including photolithography, computerized numerical control (CNC) milling and printed circuit board (PCB) manufacturing. Using this device, we present comprehensive experimental results exploring the complexity of the acoustic atomization process and the influence of fluid supply position and geometry, SAW power and fluid flow rate on the device functionality. These factors in turn influence the droplet size distribution, measured here, that is important for applications including liquid chromatography, pulmonary therapies, thin film deposition and olfactory displays.Electronic supplementary materialThe online version of this article (doi:10.1007/s10544-017-0152-9) contains supplementary material, which is available to authorized users.

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“…Droplets can be manipulated using other means such as surface acoustic waves (SAW) [ 102 , 103 , 104 ] or thermocapillary forces [ 105 , 106 ]. Acoustic energy is generated using a piezoelectric element and transferred to the droplet.…”

Section: Digital Microfluidicsmentioning

confidence: 99%

Recent Advances and Future Perspectives on Microfluidic Liquid Handling

et al. 2017

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The interdisciplinary research field of microfluidics has the potential to revolutionize current technologies that require the handling of a small amount of fluid, a fast response, low costs and automation. Microfluidic platforms that handle small amounts of liquid have been categorised as continuous-flow microfluidics and digital microfluidics. The first part of this paper discusses the recent advances of the two main and opposing applications of liquid handling in continuous-flow microfluidics: mixing and separation. Mixing and separation are essential steps in most lab-on-a-chip platforms, as sample preparation and detection are required for a variety of biological and chemical assays. The second part discusses the various digital microfluidic strategies, based on droplets and liquid marbles, for the manipulation of discrete microdroplets. More advanced digital microfluidic devices combining electrowetting with other techniques are also introduced. The applications of the emerging field of liquid-marble-based digital microfluidics are also highlighted. Finally, future perspectives on microfluidic liquid handling are discussed.

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Screen-printed digital microfluidics combined with surface acoustic wave nebulization for hydrogen-deuterium exchange measurements

Cited by 21 publications

References 43 publications

Surface acoustic wave devices for chemical sensing and microfluidics: a review and perspective

Surface acoustic wave devices for chemical sensing and microfluidics: a review and perspective

Compact SAW aerosol generator

Recent Advances and Future Perspectives on Microfluidic Liquid Handling

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