Screen-printed electrode-based biosensors modified with functional nucleic acid probes and their applications in this pandemic age: a review

Ye, Qingqing; Zhang, Zhenqi; Liu, Jian; Wang, Xuyao

doi:10.1039/d2ay00666a

Cited by 9 publications

(7 citation statements)

References 124 publications

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“…Based on the above-mentioned facts, fabrication, evaluation, and application of the microsensors based on screenprinted are very interesting challenges for many scientists. Realization of different screen-printed modified electrodes were reported [30][31][32][33][34][35][36][37][38][39]. More specifically, fabrication, potentiometric characterization, and analytical application of screenprinted microchips were reviewed in the literature.…”

Section: Introductionmentioning

confidence: 99%

“…More specifically, fabrication, potentiometric characterization, and analytical application of screenprinted microchips were reviewed in the literature. These demonstrated the description of pharmaceutical and biological species analysis [30], Ag/AgCl chloride electrode [31], calibration less pH sensors [32], sodium alkyl sulfates detection [33], printed sensors [34], pesticide detection [35], small molecule sensing [36], carbon electrodes [37], biosensors modified with functional nucleic acids probes [38], and lead cations determination [39], respectively. Furthermore, optimized screenprinted microelectrode have been recently, developed for the determination of xylometazoline [40] and cyclobenzaprine [41].…”

Section: Introductionmentioning

confidence: 99%

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Disposable Screen-Printed Microchip Based on Nanoparticles Sensitive Membrane for Potentiometric Determination of Lead

Alrobaian,

Alfadhel,

Zayed

et al. 2024

Journal of Sensors

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Realization of screen-printed disposable microchip based on organic membrane sensitive layer highly responsive to lead has been demonstrated for the first time. Fabrication, potentiometric characterization and analytical application of the novel microchip have been reported. A sensitive layer comprises TiO2 nanoparticles and multiwalled carbon nanotubes “MWCNTs” composite incorporated in PVC membrane has uploaded on the plastic screen-printed microelectrode substrate surface using novel protocol. The new chip provided a linear behavior for Pb2+ ions over the lead concentration range of 1 × 10−6–1 × 10−1 mole L−1 with super Nernstian sensitivity (49 mV), relatively long life span (>4 months), and a fast response time (10 s). The advantages showed by the microchip include simple fabrication, small size, mass production, cost effectiveness, and automation and integration feasibility. The realized new microchip has been successfully utilized in the quantification of some lead (II) samples with average recovery of 101.9% and the RDS was <3.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Disposable Screen-Printed Microchip Based on Nanoparticles Sensitive Membrane for Potentiometric Determination of Lead

Alrobaian,

Alfadhel,

Zayed

et al. 2024

Journal of Sensors

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“…Among electrochemical sensors, the use of screen-printed electrodes (SPEs) has attracted considerable attention because they are versatile, easy to build, reliable, and reproducible. Furthermore, low-cost, robustness, mass producibility, and miniaturization are also examples of the qualities that are achieved when speaking from SPE-type sensors [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Carbon Nanomaterials-Based Screen-Printed Electrodes for Sensing Applications

Silva

Camargo

et al. 2023

Biosensors

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Electrochemical sensors consisting of screen-printed electrodes (SPEs) are recurrent devices in the recent literature for applications in different fields of interest and contribute to the expanding electroanalytical chemistry field. This is due to inherent characteristics that can be better (or only) achieved with the use of SPEs, including miniaturization, cost reduction, lower sample consumption, compatibility with portable equipment, and disposability. SPEs are also quite versatile; they can be manufactured using different formulations of conductive inks and substrates, and are of varied designs. Naturally, the analytical performance of SPEs is directly affected by the quality of the material used for printing and modifying the electrodes. In this sense, the most varied carbon nanomaterials have been explored for the preparation and modification of SPEs, providing devices with an enhanced electrochemical response and greater sensitivity, in addition to functionalized surfaces that can immobilize biological agents for the manufacture of biosensors. Considering the relevance and timeliness of the topic, this review aimed to provide an overview of the current scenario of the use of carbonaceous nanomaterials in the context of making electrochemical SPE sensors, from which different approaches will be presented, exploring materials traditionally investigated in electrochemistry, such as graphene, carbon nanotubes, carbon black, and those more recently investigated for this (carbon quantum dots, graphitic carbon nitride, and biochar). Perspectives on the use and expansion of these devices are also considered.

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“…Recently, the construction of biosensing platforms on compact and flexible screen-printed electrodes (SPEs) has been under the spotlight due to the portability and mass-production ability of SPEs. Several SPE-based electrochemical sensors, particularly for glucose, ethinylestradiol [22], amphetamine [23] and even SARS-CoV-2 antigen [24], have been developed, reflecting the modified SPEs promising future in point-of-care devices and on-site analysis [25].…”

Section: Introductionmentioning

confidence: 99%

Dye adsorbed few‐layer thick Ti₃C₂T_x‐MXenes for direct electrochemical detection of CD44 proteins

et al. 2023

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The direct electrochemical detection of cancer biomarkers using single single‐component platforms is challenging. Herein, we propose constructing an efficient screen‐printed electrode (SPE) based platform for selective detection of CD44 proteins, a non‐kinase transmembrane glycoprotein. A sensing platform, MB‐MX/HA/SPE, was developed by incorporating few‐layered Ti3C2Tx nanosheets pre‐loaded with methylene blue (MB) dye. The nanosheets were subsequently immobilized with hyaluronic acid (HA), which served as a ligand for the specific recognition of CD44. The simple electrode configuration and the highly conductive Ti3C2Tx facilitated the electrochemical oxidation of MB, generating a reference SWV signal that declined proportionally with the increasing concentration of CD44 owing to ligand (HA)‐protein interaction. The sensor could register a sensitive inhibition response in the concentration range of 0.1 to 7.25 ng.mL−1 with a detection limit of 1.2×10−2 ng.mL−1 for CD44 proteins. Moreover, the synergistic combination of the highly conductive/adsorptive Ti3C2Tx nanosheets and hyaluronic acid (HA) led to strong antifouling characteristics even in the presence of other common proteins, such as bovine serum albumin (BSA), haemoglobin (Ig), immunoglobulin G (IgG), prostate‐specific antigen (PSA), and neuron‐specific enolase (NSE). The proposed strategy eliminates the need for additional components in the electrode modification procedure. In addition, incorporating MXenes as electrode material paves the way for developing sensitive biosensors with prospective applications in cancer diagnosis.

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Screen-printed electrode-based biosensors modified with functional nucleic acid probes and their applications in this pandemic age: a review

Abstract: Electrochemical methodology has probably been the most noticeable sensing platforms in the past few years as they provide superior advantages. In particular, screen printed electrode (SPE)-based sensing applications stand out...

Cited by 9 publications

References 124 publications

Disposable Screen-Printed Microchip Based on Nanoparticles Sensitive Membrane for Potentiometric Determination of Lead

Disposable Screen-Printed Microchip Based on Nanoparticles Sensitive Membrane for Potentiometric Determination of Lead

Carbon Nanomaterials-Based Screen-Printed Electrodes for Sensing Applications

Dye adsorbed few‐layer thick Ti₃C₂T_x‐MXenes for direct electrochemical detection of CD44 proteins

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Screen-printed electrode-based biosensors modified with functional nucleic acid probes and their applications in this pandemic age: a review

Abstract: Electrochemical methodology has probably been the most noticeable sensing platforms in the past few years as they provide superior advantages. In particular, screen printed electrode (SPE)-based sensing applications stand out...

Cited by 9 publications

References 124 publications

Disposable Screen-Printed Microchip Based on Nanoparticles Sensitive Membrane for Potentiometric Determination of Lead

Disposable Screen-Printed Microchip Based on Nanoparticles Sensitive Membrane for Potentiometric Determination of Lead

Carbon Nanomaterials-Based Screen-Printed Electrodes for Sensing Applications

Dye adsorbed few‐layer thick Ti3C2Tx‐MXenes for direct electrochemical detection of CD44 proteins

Contact Info

Product

Resources

About

Dye adsorbed few‐layer thick Ti₃C₂T_x‐MXenes for direct electrochemical detection of CD44 proteins