Screen-printed Modified Diamond Electrode for Glucose Detection

Abstract

An electrochemical glucose sensor based on a screen-printed diamond electrode was fabricated as a low-cost, disposable, and sensitive electrode. Amperometric detection of glucose was achieved by using a glucose-oxidase-immobilized cobalt phthalocyanine/boron-doped diamond powder (GOx-CoPc/BDDP)-printed electrode, with a linear calibration curve in the concentration range of 0.2–1.0 mM. The background current for the GOx-CoPc/BDDP-printed electrode stabilized faster than that for the GOx-CoPc/carbon-printed electrode, which confirms its practical usefulness for the detection of glucose at low concentrations.

The effect of molecular structure of organic compound on the direct high‐pressure synthesis of boron‐doped nanodiamond

“…A water suspension of the boron‐doped diamond nanoparticles with a narrow size distribution can be easily prepared from the samples synthesized at 1200–1300 °C, that essentially simplify scientific and technologic application of this material. Conductive nanodiamonds can be used for seeding during the CVD film synthesis without breaking electrical contact with the conductive substrate , as a conductive “ink” to create conductive structures , for drug delivery in biomedicine, in order to create elements of superconducting devices etc.…”

“…High‐pressure synthesis of nanodiamonds from organic compounds, reported by Wentorf half a century ago , is now becoming extremely high demanded for obtaining nanocrystals of diamond with optically and electrically active impurities. Nanodiamonds doped with optically and electrically active impurities promise attractive applications in biology, magnetometry, nanoscopy, and in different modern quantum information processing and communication technologies . Nano‐ and microcrystalline diamonds with Si–V, N–V, and Ge–V defects have been recently synthesized from naphthalene‐based mixtures of reagents at pressures of 8–9 GPa .…”

Next-Generation Diamond Electrodes for Neurochemical Sensing: Challenges and Opportunities

“…To further improve the mechanical flexibility, pre-patterned BDD MEAs can be transferred from a solid substrate onto a soft polymer substrate, such as polynorbornene [ 131 ], polyimide [ 132 ] and parylene C [ 133 , 134 ] to form BDD-on-polymer MEAs with reduced mechanical rigidity ( Figure 1 E [ 131 ] and Figure 1 F [ 133 ]). Recently, BDD paste electrodes suitable for electroanalytical applications have been reported by Kondo et al, offering a cheaper alternative to fabrication of flexible BDD MEAs [ 135 , 136 ] ( Figure 1 G [ 136 ]). These glucose sensing electrodes were constructed by screen printing of a glucose-oxidase-immobilized cobalt phthalocyanine/boron-doped diamond powders on a polyimide substrate.…”

Immobilization of glucose oxidase on graphene and cobalt phthalocyanine composite and its application for the determination of glucose

“…The 'oxygen deficit' issue can be addressed by replacing oxygen with redox mediators [3,[24][25][26][27][28][29]. MPcs are one of the suitable redox mediators and electrocatalysts to mediate the oxidation of glucose attributed to their outstanding electrochemical and physicochemical properties of MPcs such as rich redox properties, fast electron transfer kinetics, biocompatibility, high chemical and thermal stabilities [24,[30][31][32][33]. Some of the reported MPcs based mediated glucose biosensors include poly(ethylene glycol)/GOx/cobalt octaethoxyphthalocyanine [CoPc(OEt) 8 ] [30], ether-linked cobalt(II) phthalocyanine (CoPc)-cobalt(II) tetraphenylporphyrin pentamer [24], polymetallophthalocyanines/polypyrrole-GOx [31], GOx-CoPc-boron doped diamond electrode [32] and nanoscaled CoPc-GOx [33].…”