Screening active ingredients of rosemary based on spectrum-effect relationships between UPLC fingerprint and vasorelaxant activity using three chemometrics

Zhang, Jidan; Chen, Tong; Li, Ké; Xu, Haiyu; Liang, Rixin; Wang, Weihao; Li, Hua; Shao, Anwen; Yang, Bin

doi:10.1016/j.jchromb.2019.121854

Cited by 19 publications

(17 citation statements)

References 18 publications

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“…En la medicina tradicional se ha usado en el tratamiento del asma bronquial, la epilepsia, el dolor de cabeza, malestares gastrointestinales, cólicos biliares y renales (Said et al, 2019), el control de alergias, pérdida del apetito, anomalías circulatorias, complemento en el tratamiento del dolor muscular, de articulaciones y en inflamaciones (Borges et al, 2018), también como antiespasmódico, carminativo, diurético, antirreumático, antidepresivo, ansiolítico, potenciador de la fertilidad humana y la memoria (Karim, Khan, Abdelhalim, Abdel-Halim & Hanrahan, 2017), en el tratamiento de enfermedades inflamatorias y de la diabetes mellitus (Nieto et al, 2018), potenciador de la cognición y de la circulación sanguínea (Sadeh et al, 2019), expectorante, en el tratamiento de la dismenorrea, desórdenes respiratorios, dolor de garganta y de estómago (Karadağ et al, 2019), en desórdenes de la piel (Ali et al, 2019), el alivio de enfermedades cardiovasculares (Zhang et al, 2019), el tratamiento de lesiones orales (Sumintarti, Fatimasari, Hajrah-Yusuf & Ruslin, 2018), como atenuante de cataratas, tratamiento de alergias cutáneas (de Oliveira, Camargo & de Oliveira, 2019), como tónico en el tratamiento de las flatulencias y tensión nerviosa (Abbaszadeh, Layeghhaghighi, Azimi & Hadi, 2020) y control de la caspa (Trupti & Gadekar, 2018).…”

Section: Romero (R Officinalis L)unclassified

“…Su aceite esencial y extractos son antimicrobianos con propiedades antioxidantes (Basheer, 2018), anti-nefrotóxicos, antiinflamatorios, antitumorales, anti-hepatotóxicos (El-Desouky et al, 2019), antihelmínticos (Zoral et al, 2018), anticancerígenos (Karim et al, 2017), antifúngicos (Ebrahimi et al, 2020), insecticidas, antidiabéticos, antimutagénicos, anti-toxigénicos (Nieto et al, 2018), citotóxicos, analgésicos, herbicidas, hipoglucémicos, hipolipemiantes (Karadağ et al, 2019), antiartríticos (Beltrán et al, 2017), antidepresivos, antiobesidad, neuroprotectores (Hamidpour, Hamidpour & Elias, 2017), antihiperglucémicos, antihiperlipidémicos (Ali et al, 2019), antidiarreicos (Selmi, Rtibi, Grami, Sebai & Marzouki, 2017) e inhibidoreres de la germinación de semillas (Sadeh et al, 2019), efecto inhibidor contra el VIH (Barbieri et al, 2019), vasorrelajantes (Zhang et al, 2019), antivirales (Sumintarti et al, 2018), antitrombóticos (Elyemni et al, 2019), hipouricémicos, proapoptóticos (de Oliveira et al, 2019), anti-infecciosos, espasmolíticos (Gomes et al, 2020), entre otros más.…”

Section: Romero (R Officinalis L)unclassified

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Romero (Rosmarinus officinalis L.): su origen, importancia y generalidades de sus metabolitos secundarios

et al. 2020

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El presente trabajo, es una revisión que muestra el impacto que tiene el uso de las plantas medicinales en la salud humana. Desde la antigüedad, por tradición, se extendió el uso mayoritario de algunas familias vegetales como la Lamiaceae que destaca por sus propiedades aromáticas y aplicación culinaria en numerosas culturas, así como en el tratamiento y prevención de una gran variedad de enfermedades y malestares. Dentro de las especies pertenecientes a esta familia se encuentra el romero (Rosmarinus officinalis), planta que ha ganado importancia en el campo de la investigación por sus diversos atributos biológicos como: antiinflamatorio, antimicrobiano, antioxidante y anticancerígeno, entre otros; resultados que debe a sus metabolitos secundarios como: el ácido carnósico, el carnosol, el ácido rosmárico y el alcanfor, entre otros más, aunado a un potencial efecto cuando es aplicado. También se mencionan algunas metodologías que buscan la extracción de los componentes biológicamente activos del romero.

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Section: Romero (R Officinalis L)unclassified

Romero (Rosmarinus officinalis L.): su origen, importancia y generalidades de sus metabolitos secundarios

et al. 2020

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“…Nowadays, spectrum-effect is used to study the relationship between components and efficacy of traditional Chinese medicines. For example, the main vasorelaxant components of rosemary have been found by using the chemical spectrum-effect relationship [ 19 ]. HPLC fingerprint and bioactivity verification were used to investigate the potential correlation between the chemical components and pharmaceutical effects [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Spectrum-Effect Relationship between HPLC Fingerprints and Antioxidant Activity of Yangyin Tongnao Prescription

Zhang

Zhao

et al. 2021

Journal of Analytical Methods in Chemistry

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Yangyin Tongnao (YYTN) prescription is used as a traditional Chinese herbal formula, and it has antioxidant activity that mainly contributes in the treatment of cardiovascular and cerebrovascular diseases. However, the compounds related to its antioxidant activity are still unknown. In the present study, the fingerprints of YYTN extracts under different extraction conditions were obtained by high performance liquid chromatography (HPLC) to identify the common peaks to all the samples processed. A 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity assay and ferric reducing antioxidant power (FRAP) assay were carried out to evaluate the antioxidant activity of the extracts. Spectrum-effect relationship between HPLC fingerprints and antioxidant activity of YYTN was assessed by Pearson product-moment correlation coefficient (PPMCC) and multiple linear regression analysis (MLRA). The results showed that peaks 5, 6, 13, 15, and 24 of the fingerprints were closely connected to antioxidant activity. Five peaks were identified: vanillic acid (P5), puerarin (P7), ferulic acid (P13), daidzein (P21), and formononetin (P23). Our study successfully established the spectrum-effect relationship between HPLC fingerprints and antioxidant activity of YYTN, which provided a general method for establishing quality standards with a combination of chromatography and antioxidant activity.

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“…"Pharmacodynamics" data is acquired by the biomodels usually [25]. e methods of data processing, mainly include principal component analysis (PCA), partial least squares (PLS) regression analysis, orthogonal partial least squares-discriminant analysis (OPLS-DA), canonical correlation analysis (CCA), and grey relational analysis (GRA) usually [26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

Selecting and Characterizing Tyrosinase Inhibitors from Atractylodis macrocephalae Rhizoma Based on Spectrum-Activity Relationship and Molecular Docking

Yong-qin

Liang

et al. 2021

Journal of Analytical Methods in Chemistry

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Atractylodis macrocephalae Rhizoma (AMR) is a famous classical Chinese traditional medicine (CTM), which has been used as a tonic for many diseases for thousands of years. In ancient China, it was used as a supplementary food for beauty in the palace. In preliminary studies, the function of whitening skin and the significant inhibiting effect on tyrosinase (TYR) which is the reactive enzyme in the composition of melanin of AMR were discovered, and the relevant research was rarely reported. In this study, high-performance liquid chromatography (HPLC) along with partial least squares regression analysis (PLS) was applied to survey the coherence between the chemical constituents and the inhibiting activity of 11 batches of AMR on TYR activity. The results of PLS showed that the chromatographic peaks 11 (atractylenolide III) and 15 could be important effective ingredients of the inhibition TYR activity as ascertained by spectrum-activity relationships. Furthermore, TYR inhibitory activity of atractylenolide III was validated by in vitro test by β-arbutin served as a positive control drug. The results of the in vitro test and the molecular docking showed that atractylenolide III has high TYR inhibitory activity and could link to the residues in TYR catalytic pocket. Therefore, bioassay, molecular docking, and spectrum-activity relationships are appropriate for linking the quality of samples with pharmaceutical-related active ingredients. And our studying would lay a theoretical foundation for applying the water extracts of AMR in whitening cosmetics.

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Screening active ingredients of rosemary based on spectrum-effect relationships between UPLC fingerprint and vasorelaxant activity using three chemometrics

Cited by 19 publications

References 18 publications

Romero (Rosmarinus officinalis L.): su origen, importancia y generalidades de sus metabolitos secundarios

Romero (Rosmarinus officinalis L.): su origen, importancia y generalidades de sus metabolitos secundarios

Spectrum-Effect Relationship between HPLC Fingerprints and Antioxidant Activity of Yangyin Tongnao Prescription

Selecting and Characterizing Tyrosinase Inhibitors from Atractylodis macrocephalae Rhizoma Based on Spectrum-Activity Relationship and Molecular Docking

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