Screening and Identification of the Metabolites in Rat Plasma and Urine after Oral Administration of Areca catechu L. Nut Extract by Ultra-High-Pressure Liquid Chromatography Coupled with Linear Ion Trap–Orbitrap Tandem Mass Spectrometry

Li, Lulu; Luo, Zhiqiang; Yang, Liu; Wang, Hao; Liu, Aoxue; Yang, Guohua; Li, Mengwei; Yang, Ruirui; Chen, Xinjing; Zhu, Junjie; Zhao, Baosheng

doi:10.3390/molecules22061026

Cited by 11 publications

(8 citation statements)

References 27 publications

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“…The investigation on avan-3-ols con rmed the presence of (epi)catechin (m/z 291.0869) and (epi)gallocatechin (m/z 307.0832). The rst generated fragment ions of m/z 273, 165, 139, and 123 were already been validated in a previous report [49]. Otherwise, (epi)gallocatechin showed characteristic fragments such as m/z…”

Section: Flavan-3-olsmentioning

confidence: 70%

Chemical Diversity and In Vitro/In Silico Antiviral Activity of Extracts from Different Parts of Phyllanthus brasiliensis (Aubl.) Poir

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Reis

Gomes

et al. 2023

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Introduction: Plants of the genus Phyllanthus (Euphorbiaceae), the “stone breaker” has long been used in folk medicine to treat hepatitis B, an important viral disease. In this regard some species of this genus were tested against viruses as Herpes simplex virus type 1 (HSV-1), COVID and Hepatitis C virus (HCV), showing expressive inhibition in some of them, attracting attention to the genus and to its chemical constituents. Although P. brasiliensis has no traditional use as an antiviral plant, these findings urge us to consider whether P. brasiliensis, plant widely distributed in the Brazilian Amazon and its compounds have antiviral activity against Vero cell lines infected with Mayaro, Oropouche, Chikungunya, and Zika viruses. Objectives: Thus, herein we describe a study of extracts' chemical diversity, antiviral activity, and specialized metabolites detected in different parts of the Phyllanthus brasiliensis (Aubl.) Poir., Methods: In this context, liquid chromatography-mass spectrometry is a crucial analytical method to reveal the identity of many drug candidates from extracts from medicinal plants used to treat diseases, including for instance infections by viruses. Results: As result, 44 compounds were annotated by mass spectrometry-based molecular networking approach. Along, the extracts were tested against Vero cell lines infected with Mayaro, Oropouche, Chikungunya, and Zika viruses. Overall, the results revealed that this species is high in fatty acids, flavones, flavan-3-ols, and lignans. Among them, especially lignans are known to have promising antiviral properties. In this context, in vitro assays revealed potent antiviral activity against different viruses, especially lignan-rich extracts MEB (EC50 = 0.80 µg.mL− 1, SI = 377.59), MEL (EC50 = 0.84 µg.mL− 1, SI = 297.62), and HEL (EC50 = 1.36 µg.mL− 1, SI = 735.29) against Zika virus (ZIKV). Conclusions: The potential of lignans was also supported by in silico antiviral prediction, and Tuberculatin (a lignan) stood out with high activity score and as a strong candidate from MEL extract. Therefore, authors believe that P. brasiliensis extracts contain metabolites that could be a new kick-off point with candidates for antiviral drug development, with lignans becoming a promising trend for further virology research.

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Section: Flavan-3-olsmentioning

confidence: 70%

Chemical Diversity and In Vitro/In Silico Antiviral Activity of Extracts from Different Parts of Phyllanthus brasiliensis (Aubl.) Poir

Carvalho

Reis

Gomes

et al. 2023

Preprint

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show abstract

“…Areca catechu L. nut is a well-known traditional herbal medicine, which has been recorded in the pharmacopoeia of China. Areca catechu is known for the treatment of parasitic diseases, dyspepsia, anti-depressant, and anti-migraine effects [ 169 , 170 ]. However, areca catechu is a group 1 carcinogen and related to oral disorders including submucous fibrosis, oral leukoplakia, and erythroplakia, oral lichenoid lesions, and oral cancer [ 171 , 172 ].…”

Section: Limitations Prospects and Conclusionmentioning

confidence: 99%

Traditional Chinese medicine promotes bone regeneration in bone tissue engineering

et al. 2022

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Bone tissue engineering (BTE) is a promising method for the repair of difficult-to-heal bone tissue damage by providing three-dimensional structures for cell attachment, proliferation, and differentiation. Traditional Chinese medicine (TCM) has been introduced as an effective global medical program by the World Health Organization, comprising intricate components, and promoting bone regeneration by regulating multiple mechanisms and targets. This study outlines the potential therapeutic capabilities of TCM combined with BTE in bone regeneration. The effective active components promoting bone regeneration can be generally divided into flavonoids, alkaloids, glycosides, terpenoids, and polyphenols, among others. The chemical structures of the monomers, their sources, efficacy, and mechanisms are described. We summarize the use of compounds and medicinal parts of TCM to stimulate bone regeneration. Finally, the limitations and prospects of applying TCM in BTE are introduced, providing a direction for further development of novel and potential TCM. Graphical Abstract

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“…Gingerol was isolated from Pinellia pedatisecta Schott, arecoline from Areca catechu L. and the rest of the selected compounds were isolated from Tinospora cordifolia (Willd.). P. pedatisecta as well as A. catechu are well-known in Chinese medicine as anti-inflammatory agents ( Li et al, 2017 ; Wang et al, 2019 ). T. cordifolia is also known in Asian traditional medicine as an anti-inflammatory agent ( Yates et al, 2021 ).…”

Section: Pharmacological Modulation Of Phagocytosis Via Medical Plantsmentioning

confidence: 99%

Phagocytosis, Degranulation and Extracellular Traps Release by Neutrophils—The Current Knowledge, Pharmacological Modulation and Future Prospects

et al. 2021

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Neutrophils are crucial elements of innate immune system, which assure host defense via a range of effector functions, such as phagocytosis, degranulation, and NET formation. The latest literature clearly indicates that modulation of effector functions of neutrophils may affect the treatment efficacy. Pharmacological modulation may affect molecular mechanisms activating or suppressing phagocytosis, degranulation or NET formation. In this review, we describe the role of neutrophils in physiology and in the course of bacterial and viral infections, illustrating the versatility and plasticity of those cells. This review also focus on the action of plant extracts, plant-derived compounds and synthetic drugs on effector functions of neutrophils. These recent advances in the knowledge can help to devise novel therapeutic approaches via pharmacological modulation of the described processes.

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Screening and Identification of the Metabolites in Rat Plasma and Urine after Oral Administration of Areca catechu L. Nut Extract by Ultra-High-Pressure Liquid Chromatography Coupled with Linear Ion Trap–Orbitrap Tandem Mass Spectrometry

Cited by 11 publications

References 27 publications

Chemical Diversity and In Vitro/In Silico Antiviral Activity of Extracts from Different Parts of Phyllanthus brasiliensis (Aubl.) Poir

Chemical Diversity and In Vitro/In Silico Antiviral Activity of Extracts from Different Parts of Phyllanthus brasiliensis (Aubl.) Poir

Traditional Chinese medicine promotes bone regeneration in bone tissue engineering

Phagocytosis, Degranulation and Extracellular Traps Release by Neutrophils—The Current Knowledge, Pharmacological Modulation and Future Prospects

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