Screening Circulating Tumor Cells as a Non-invasive Cancer Test in 1,585 Asymptomatic Adults (ICELLATE1)

Castro, Juan Manuel; Sánchez, Luis A.; Bedoya, Pierino H Alvarez; Nuñez, María Teresa; Lü, Ming; Castro, Tomas; Sharifi, Hamid R; Ericsson, Christer

doi:10.4172/2329-6771.1000212

J Integr Oncol

2018

DOI: 10.4172/2329-6771.1000212

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Screening Circulating Tumor Cells as a Non-invasive Cancer Test in 1,585 Asymptomatic Adults (ICELLATE1)

Juan Manuel Castro¹,

Luis A. Sánchez²,

Pierino H Alvarez Bedoya³

et al.

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“…Cancer cell screening is an approach to reduce cancer-related morbidity and mortality rates. − In situ quantification and imaging of multifunctional molecules in cells is a powerful basis for cancer cell sorting and early diagnosis, especially at the single-cell level. This purpose cannot be simply realized by cell lysate analysis, because the extraction or purification procedure may alter the intrinsic highly crowded cellular environment including pH, ionic strength and composition, redox potential, and concentrations of related metabolites and effector molecules .…”

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Quantitative Detection and Imaging of Multiple Biological Molecules in Living Cells for Cell Screening

et al. 2020

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Because of insufficient information, a single biomarker is not sufficient for early diagnosis of cancer, whereas sensitive and selective detection of multiple biomolecules can significantly reduce analysis time, sample size, and accurately perform cell screening in early cancer. Therefore, the development of a noninvasive strategy that can simultaneously quantify multiple biomarkers (i.e., nucleic acids, proteins, and small molecules) in a single cell is particularly important. Herein, a universal sensing system (functional DNA@mesoporous silica nanoparticles (MSN)–Black Hole Quencher–rhodamine 6G (RhB), FDSBR), which is based on the combination of functionalized DNA and smart responsive nanomaterial, was successfully constructed. After incubation with the cells, different types of targets trigger the strand displacement reaction to release the fluorophore-labeled nucleic acids as the output signals to reflect the intracellular level of the telomerase and adenosine triphosphate (ATP), respectively. Simultaneously, intracellular miR-21 can be clearly indicated by the restored fluorescence of RhB when the caged double-stranded DNA was substituted into single-stranded DNA to open the pore. The concentrations of intracellular telomerase, miR-21, and ATP were identified successfully in three cell lines at the single-cell level. The results show that the contents of three biomolecules have significant differences in the three model cell lines and provide a promising route for developing innovative early disease diagnosis and cell screening assay.

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Quantitative Detection and Imaging of Multiple Biological Molecules in Living Cells for Cell Screening

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Clinical Significance of Circulating Tumor Cells in Epithelial Appendiceal Neoplasms with Peritoneal Metastases

Frühling,

Moberg,

Ghanipour

et al. 2024

Cancers

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Appendiceal tumors are uncommon and, at times, discovered incidentally during histological examination. The histopathological classification of the disease is complex and has generated some controversy. The analysis of circulating tumor cells can be used for the early detection of metastatic potential. The aim of the present study was to examine the prognostic value of circulating tumor cells in patients with appendiceal tumors and peritoneal metastases. To our knowledge, this is the first study to examine CTCs in appendiceal tumors. We performed a prospective cohort study of consecutive patients treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy between 2015 and 2019 at a HIPEC referral center. In total, 31 patients were included in the analysis, and circulating tumor cells were detected in 15 patients (48%). CTC positivity was not associated with overall or recurrence-free survival, nor was it correlated with PCI score or histopathological grading. Surprisingly, however, CTCs were found in almost half the patients. The presence or quantities of these cells did not, on their own, predict systemic metastatic potential during the observed time, and they did not appear to significantly correlate with the oncological outcomes recorded.

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Screening Circulating Tumor Cells as a Non-invasive Cancer Test in 1,585 Asymptomatic Adults (ICELLATE1)

Cited by 2 publications

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Quantitative Detection and Imaging of Multiple Biological Molecules in Living Cells for Cell Screening

Quantitative Detection and Imaging of Multiple Biological Molecules in Living Cells for Cell Screening

Clinical Significance of Circulating Tumor Cells in Epithelial Appendiceal Neoplasms with Peritoneal Metastases

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