Screening Donated Blood for Transfusion Transmitted Infections by Serology along with NAT and Response Rate to Notification of Reactive Results: An Indian Experience

Abstract

Background. Transfusion safety begins with healthy donors. A fundamental part of preventing transfusion transmitted infections (TTIs) is to notify and counsel reactive donors. Donor notification and counselling protect the health of the donor and prevent secondary transmission of infectious diseases. Methods. 113,014 donations were screened for TTIs, namely, HIV, HBV, HCV, and syphilis, by serology and nucleic acid testing. All reactive donors were retested (wherever possible) and notified of their status by telephone or letter. All initial reactive screens were followed over six months. Results. We evaluated 2,838 (2.51%) cases with reactive screening test results (1.38% HBV, 0.54% HCV, 0.27% HIV, and 0.32% syphilis). Only 23.3% of donors (662) responded to notification. The response among voluntary donors was better as compared to the replacement donors (43.6% versus 21.2%). Only 373 (56.3%) responsive donors followed their first attendance at referral specialties. Over six months, only 176 of 662 (26.6%) reactive donors received treatment. Conclusion. Our study shed light on the importance of proper donor counselling and notification of TTI status to all reactive donors who opt to receive this information. There is also an urgent need to formulate the nationally acceptable guidelines for notification and follow-up of reactive donors.

Five years of experience with ID‐NAT at a tertiary care centre in North India: An interdictory step in preventing the transfusion‐transmitted Infections

“…The NAT yield rate of one in 847 is higher than the first study result (one in 2622) reported by Chatterjee et al at our centre [14]. Agarwal et al and Chaurasia et al have reported a higher NAT yield of one in 610 and one in 628, respectively [12,13]. These variabilities in NAT yield rates could be attributed to much larger sample size taken into account in the current study.…”

“…and Chaurasia et al . have reported a higher NAT yield of one in 610 and one in 628, respectively . These variabilities in NAT yield rates could be attributed to much larger sample size taken into account in the current study.…”

Correlation of razor hygiene with HIV disease transmission risk in barber shop

“…For example, transmission through blood transfusion despite the high odds, but in fact such cases are very rare, because of transmission through blood transfusion can be controlled through the process of screening blood donors beforehand calor (John, 2011). If found blood containing the HIV virus during the screening process, then the blood will not be used for blood transfusions (Chaurasia et al, 2014;Shitu et al, 2014). Instead, transmission through the razor is still a serious concern for everyone.…”

Chemiluminescence brings renaissance in TTI screening: Primi experientia

“…[1234] Majority of the blood banks in India are using ELISA-based serologic screening for transfusion-transmissible viral infections (TTIs). The automated platform for chemiluminescence (ACLS) has been introduced in the recent past, as a newer serological screening tool that offers good precision, reliability, and high throughput.…”