Screening druggable targets and predicting therapeutic drugs for COVID-19 via integrated bioinformatics analysis

Tan, Siyuan; Chen, Wenyan; Xiang, Hongxian; Kong, Gaoyin; Zou, Lianhong; Wei, Lai

doi:10.1007/s13258-020-01021-8

Cited by 3 publications

(2 citation statements)

References 46 publications

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“…Here, the functional enrichment analysis of the genes were done through g:Profiler, where the results characterized into GO ID and p-value with highest involved in the biological process (337), followed by cellular component (99) and molecular function (67). Recently, this kind of characterization and annotation of genes were used to predict therapeutic drugs against COVID-19 (Tan et al 2021 ), validation of immune genes (Karthikeyan et al 2021 ), identification of novel prognostic biomarker (Xu et al 2020 ), and analyses of Integrated Gene Expression Profiling Data (IGEPA) (You et al 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Genome skimming-based simple sequence repeat (SSR) marker discovery and characterization in Grevillea robusta

Dabral

Shamoon

Meena

et al. 2021

Physiol Mol Biol Plants

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Section: Discussionmentioning

confidence: 99%

Genome skimming-based simple sequence repeat (SSR) marker discovery and characterization in Grevillea robusta

Dabral

Shamoon

Meena

et al. 2021

Physiol Mol Biol Plants

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“…A similar finding was also presented by Sallenave and Guillot (2020), whose study identified a furin-like cleavage site in SARS-CoV-2 to facilitate the S protein priming, they also claimed that furin inhibitors can be targeted as potential drug therapies for SARS-CoV-2. CXCL10: CXCL10 is a frequently studied gene in multiple COVID-19 genetic studies (Bermejo-Martin et al, 2020;Chua et al, 2020;Hou et al, 2020;Parkinson et al, 2020;Xiong et al, 2020;Han et al, 2021;Tan et al, 2021). Among those studies, a paper published on Nature Biotechnology identified that critical COVID-19 cases had shown stronger interactions between epithelial and immune cells which includes inflammatory macrophages expressing CXCL10 (Chua et al, 2020).…”

Section: Rawmentioning

confidence: 99%

Profiling COVID-19 Genetic Research: A Data-Driven Study Utilizing Intelligent Bibliometrics

Zhang

Grosser³

et al. 2021

Front. Res. Metr. Anal.

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The COVID-19 pandemic constitutes an ongoing worldwide threat to human society and has caused massive impacts on global public health, the economy and the political landscape. The key to gaining control of the disease lies in understanding the genetics of SARS-CoV-2 and the disease spectrum that follows infection. This study leverages traditional and intelligent bibliometric methods to conduct a multi-dimensional analysis on 5,632 COVID-19 genetic research papers, revealing that 1) the key players include research institutions from the United States, China, Britain and Canada; 2) research topics predominantly focus on virus infection mechanisms, virus testing, gene expression related to the immune reactions and patient clinical manifestation; 3) studies originated from the comparison of SARS-CoV-2 to previous human coronaviruses, following which research directions diverge into the analysis of virus molecular structure and genetics, the human immune response, vaccine development and gene expression related to immune responses; and 4) genes that are frequently highlighted include ACE2, IL6, TMPRSS2, and TNF. Emerging genes to the COVID-19 consist of FURIN, CXCL10, OAS1, OAS2, OAS3, and ISG15. This study demonstrates that our suite of novel bibliometric tools could help biomedical researchers follow this rapidly growing field and provide substantial evidence for policymakers’ decision-making on science policy and public health administration.

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The importance of genomic analysis in cracking the coronavirus pandemic

Zella

Giovanetti

Cocco

et al. 2021

Expert Review of Molecular Diagnostics

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Introduction : Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has pushed the scientific community to undertake intense research efforts. Understanding SARS-CoV-2 biology is necessary to discover therapeutic or preventive strategies capable of containing the pandemic. Knowledge of the structural characteristics of the virus genome and proteins is essential to find targets for therapies and immunological interventions. Areas covered : This review covers different areas of expertise, genomic analysis of circulating strains, structural biology, viral mutations, molecular diagnostics, disease, and vaccines. In particular, the review is focused on the molecular approaches and modern clinical strategies used in these fields. Expert opinion : Molecular approaches to SARS-CoV-2 pandemic have been critical to shorten time for new diagnostic, therapeutic and prevention strategies. In this perspective, the entire scientific community is moving in the same direction. Vaccines, together with the development of new drugs to treat the disease, represent the most important strategy to protect human from viral disease and prevent further spread. In this regard, new molecular technologies have been successfully implemented. The use of a novel strategy of communication is suggested for a better diffusion to the broader public of new data and results.

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Screening druggable targets and predicting therapeutic drugs for COVID-19 via integrated bioinformatics analysis

Cited by 3 publications

References 46 publications

Genome skimming-based simple sequence repeat (SSR) marker discovery and characterization in Grevillea robusta

Genome skimming-based simple sequence repeat (SSR) marker discovery and characterization in Grevillea robusta

Profiling COVID-19 Genetic Research: A Data-Driven Study Utilizing Intelligent Bibliometrics

The importance of genomic analysis in cracking the coronavirus pandemic

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