Screening for and Treatment of Polycystic Ovary Syndrome in Teenagers

Salmi, Darren; Zisser, Howard; Jovanovič, Lois

doi:10.1177/153537020422900504

Cited by 41 publications

(27 citation statements)

References 82 publications

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“…[1][2][3] Identifying women for PCOs and timely intervention is necessary to prevent long term consequences of metabolic syndrome. [12][13][14] India is on the verge of becoming the diabetes capital of the world and young teen age girls with PCOS are contributing to it.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and symptomatology of polycystic ovarian syndrome in Indian women: is there a rising incidence?

Choudhary¹,

Jain²,

Chaudhari³

2017

Int J Reprod Contracept Obstet Gynecol

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Background: Polycystic ovarian syndrome [PCOS] is a complex ill understood hormonal disorder resulting in myriads of symptoms like irregular menses, hyperandrogenism, metabolic disturbances and infertility. It occurs in about 8-11% of reproductive age group women. Recently changing lifestyles and rising obesity worldwide have contributed to rise in the incidence of PCOS. Objective of the present is to study the prevalence and symptomatology of PCOS in Indian women.Methods: 170 women in reproductive age group, with irregular menstrual cycles attending OPD, voluntarily participated in a cross sectional study. All were subjected to detailed history, examination and investigated with a battery of lab tests to confirm PCOS. Out of 170 women investigated 70 women with features of PCOS were included in the study (diagnosed as PCOS by NIH criteria).Results: The overall prevalence of PCOS in the study population was, 41%. It was 16% in married women and 24 % in unmarried girls. Common menstrual irregularity was-oligomenorrhea (40%), Menorrhagia (12.8%) amenorrhea (11%). Common symptoms were hirsutism, acne, infertility and alopecia.Conclusions: PCOS is rising in young women and to some extent the changing lifestyle in urban women may be linked to it. There in a world-wide increase in the incidence of obesity, diabetes mellitus and metabolic syndrome, PCOS and its accompanying insulin resistance is contributing to it. Treating PCOS and its complications is adding to health care burden.

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Section: Discussionmentioning

confidence: 99%

Prevalence and symptomatology of polycystic ovarian syndrome in Indian women: is there a rising incidence?

Choudhary¹,

Jain²,

Chaudhari³

2017

Int J Reprod Contracept Obstet Gynecol

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“…Clinical obElevated serum AMH in adolescent and young adult Chinese patients wkw 17-18/2010 © Springer-Verlag servations have shown interesting similarities between the physiological changes of puberty and the pathological features of PCOS, such as menstrual irregularity, increased ovarian and adrenal steroidogenesis, multiple follicles in ultrasound, hyperinsulinemia [3]. It is hard to diff erentiate the multiple follicles and polycystic follicles in adolescents by ultrasonography [4]. Th erefore, a new index might be helpful for diagnosing PCOS in adolescent and young adult patients.…”

Section: Introductionmentioning

confidence: 96%

Elevated serum anti-mullerian hormone in adolescent and young adult Chinese patients with polycystic ovary syndrome

Chen

et al. 2010

Wien Klin Wochenschr

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“…Weight loss improves practically every parameter of PCOS [35]. Healthy diet and regular exercise are the most beneficial therapies in treating PCOS symptoms and preventing future complications.…”

Section: Treatmentmentioning

confidence: 99%

Current Approaches to the Diagnosis and Treatment of Polycystic Ovarian Syndrome in Youth

2007

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Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies in reproductive-age women. It often presents during late adolescence but in some cases certain features are evident even before menarche. PCOS is a spectrum of disorders with any combination of oligo/anovulation, clinical and/or biochemical evidence of androgen excess, obesity, insulin resistance and polycystic ovaries on ultrasound. The pathogenesis is unknown; however, it is a complex multigenetic disorder where disordered gonadotropin release, dysregulation of steroidogenesis, hyperinsulinism and insulin resistance play a role. The diagnosis is based on a typical physical exam (acne, hirsutism, obesity, and acanthosis nigricans) and laboratory evidence of hyperandrogenism, such as elevated free testosterone, androstenedione and dehydroepiandrosterone sulfate (DHEAS), decreased sex hormone-binding globulin (SHBG) and increased luteinizing hormone (LH). An ovarian ultrasound may detect the multiple cysts. Secondary causes of PCOS need to be excluded. There are several classes of medications correcting different parameters of PCOS that can be used alone or in combination. Oral contraceptive therapy is used to reduce androgen and LH levels with resultant improvement in acne and hirsutism, and the induction of regular menses. Antiandrogens are usually required for a substantial improvement in hirsutism score. Insulin sensitizers such as metformin are a new class of drugs utilized in treatment of PCOS. By improving insulin sensitivity and decreasing insulin levels, they improve the unfavorable metabolic profile of patients with PCOS. Metformin also helps to increase SHBG, decrease androgen levels and induce ovulation. Despite all the available medications, life-style changes are the mainstay of therapy as weight loss and exercise improve all parameters of PCOS without the potential side effects of medication.

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Screening for and Treatment of Polycystic Ovary Syndrome in Teenagers

Cited by 41 publications

References 82 publications

Prevalence and symptomatology of polycystic ovarian syndrome in Indian women: is there a rising incidence?

Prevalence and symptomatology of polycystic ovarian syndrome in Indian women: is there a rising incidence?

Elevated serum anti-mullerian hormone in adolescent and young adult Chinese patients with polycystic ovary syndrome

Current Approaches to the Diagnosis and Treatment of Polycystic Ovarian Syndrome in Youth

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