Screening for antimicrobial activity and for alkaloids of Nauclea latifolia

Acute and Sub-Acute Toxicity of Aqueous Extract of <i>Nauclea Latifolia</i> in Swiss Mice and in OFA Rats

“…The plant is also used as a chewing stick [2] and in the treatment of ailments like gastrointestinal tract disorders, tuberculosis, sleeping sickness, prolongs menstrual flow, hypertension and malaria [3][4][5][6][7][8][9]. More recently, it had been reported the presence of biologically active principles in the extract with anti-nociceptive, antiinflammatory and anti-pyretic activities that justifies its use in malaria ethnopharmacy and subsequent development for clinical application [1].…”

Antimalarial activity and toxicity evaluation of a quantified Nauclea pobeguinii extract

“…In DR Congo, Nauclea latifolia is used in combination with Cassia occidentalis to produce an enhanced traditional medicine (Médicaments Traditionnels Améliorés, MTA) that is commercialized for treatment of uncomplicated malaria (Pousset, 2006). The alkaloids from the genus Nauclea, which are mostly indole alkaloids and their glucosylated derivatives, may in large part be responsible for the various biological activities, including antimalarial activity (Deeni and Hussain, 1991;Phillipson, 1982). Azas et al (2002) reported IC 50 values of 6.8 ± 1.5 and 7.5 ± 1.5 g/ml for the total alkaloids from Nauclea latifolia against the chloroquine-resitant W2 and the chloroquine-sensitive D6 strains of Plasmodium falciparum.…”

Genotoxic and clastogenic activity of saponins extracted from Nauclea bark as assessed by the micronucleus and the comet assays in Chinese Hamster Ovary cells

“…The use of Nauclea plants in traditional medicine has been supported by several experimental studies which have demonstrated the effectiveness of stem bark or root extracts as antiplasmodial (Benoit-Vical et al, 1998), antimicrobial (Deeni and Hussain, 1991), anti-inflammatory (Otimenyin and Uguru, 2006) and antipyretic agents (NgoBum et al, 2009). On the other hand, phytochemical investigations have revealed the presence of a great variety of biologically active compounds such as monoterpenes (Shigemori et al, 2003), indole alkaloid glycosides (Lamidi et al, 1995) and saponins with a great diversity of pharmacological properties.…”

“…In Nigeria, Nauclea latifolia is used as a chewing stick and as a remedy against stomach ache and tuberculosis (Deeni and Hussain, 1991). In Ivory Coast, infusions and decoctions from stems and roots of Nauclea latifolia are used against malaria (Benoit-Vical et al, 1998).…”