Screening for Compositae contact sensitization with sesquiterpene lactones and Compositae mix 2.5% pet

Background Clinical surveillance of the prevalence of contact allergy in consecutively patch tested patients is a proven instrument to continually assess the importance of contact allergens (haptens) assembled in a baseline series. Objectives To present current results from the European Surveillance System on Contact Allergies, including 13 countries represented by 1 to 11 departments. Methods Anonymized or pseudonymized patch test and clinical data from various data capture systems used locally or nationally as transferred to the Erlangen data centre were pooled and descriptively analysed after quality control. Results In the 4 years (2015‐2018), data from 51 914 patients patch tested with the European baseline series (EBS) of contact allergens were analysed. Contact allergy to nickel was most frequent (17.6% positive), followed by contact allergy to fragrance mix I (6.9%), methylisothiazolinone (MI; 6.2%), and Myroxylon pereirae resin (balsam of Peru; 5.8%). Conclusions While the prevalence of MI contact allergy decreased substantially following regulatory intervention, the persistently high levels of allergy to metals, fragrances, other preservatives, and rubber chemicals point to problems needing further research and, potentially, preventive efforts. Results with national additions to the baseline series provide important information on substances possibly to be considered for inclusion in the EBS.

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“…Some suggest a combination with Compositae mix II 2.5% pet. and parthenolide 0.1% pet 53 . However, while the original Compositae mix I 5% pet.…”

Section: Discussionmentioning

confidence: 96%

Patch test results with the European baseline series and additions thereof in the ESSCA network, 2015‐2018

et al. 2020

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“…A recent study suggests screening for Compositae sensitization by testing STL mix but also CM II 2.5% pet. and parthenolide . However, when sensitization to a specific Compositae is suspected, the same authors advise testing of supplementary plant extracts based on patients’ history.…”

Section: Discussionmentioning

confidence: 99%

Airborne allergic contact dermatitis caused by artichoke

et al. 2020

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K E Y W O R D S : airborne, allergic contact dermatitis, artichoke, case report, plant, sesquiterpene lactones CASE REPORTS Case 1. A 71-year-old nonatopic woman was referred for evaluation of erythematous and edematous lesions on her face and left forearm with scaling during the following days (Figure 1). She reported a similar episode the year before, during the same season, around March. Both episodes occurred shortly after she handled artichokes and cardoons (artichoke thistle; Cynara cardunculus) in her garden. Patch tests were performed on the upper back using IQ Ultra chambers (Chemotechnique Diagnostics, Vellinge, Sweden) occluded for 2 days with Opertape (Iberhospitex, Innovative Health Technologies, Barcelona, Spain). The European baseline series was tested along with additional series from the réseau de vigilance en dermato-allergologie group, a plant series (except for Taraxacum officinale and Tanacetum vulgare extracts), the leaf and stalk of common artichokes "as is," and were read on day (D) 2 and D4 according to the ESCD recommendations. 1 Positive reactions with sesquiterpene lactone (STL) mix 0.1% pet. (+ on D2, ++ on D4), Compositae mix (CM) II 5% pet. (++ on D2 and D4), Chrysanthemum cinerariaefolium extract 1.0% pet. (+ on D2, ++ on D4), parthenolide 0.1% pet. (+ on D4), and to artichoke leaf (+ on D2, ++ on D4) were observed (Figure 2(A)).Cardoon was not tested.Case 2. A 41-year-old man with a history of seasonal rhinoconjunctivitis was referred for severe eczematous lesions on his face, neck, and forearms (Figure 3). Cutaneous lesions relapsed whenever he worked as a seasonal employee in a farming cooperative (where he had been working for 4 years), mainly handling artichokes.The same patch tests series as in the previous patient were tested, and positive test reactions to methyldibromo glutaronitrile 0.5% pet.(+ on D3), STL mix 0.1% pet. (++ on D3), CM II 5% pet. (?+ on D3), artichoke stalk (+ on D2 and D3), and to dried artichoke stalk and leaf (+ on D2 and ++ on D3) (Figure 2(B)) were observed. No skin relapse was observed after he stopped handling artichokes, although he continued to work in the same place.

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“…The prevalence of SL mix patch test reactions is surprisingly high (2.8%) in children and adolescents, confirming SL mix to be a useful screening agent in our area 23 . However, CM/CM II 5% are very good supplementary allergens, and we cannot rule out an even higher prevalence of Compositae sensitization if either of these had been used as a screening mix.…”

Section: Discussionmentioning

confidence: 78%

“…In the Swedish study, 20 two cases of alleged active sensitization were noted, but lowering the concentration of CM 5% to 2.5% means that some cases of sensitization will be missed: two children with doubtful reactions to CM 2.5% had positive reactions to CM 5% (Table 1). Because of these findings, we interpret doubtful reactions to CM 2.5% in both children and adults as possible markers of Compositae contact allergy and supplement with CM 5%/CM II 5% 23 . Of course, we cannot rule out that the prevalence of Compositae sensitization in children would be even higher if all children were screened with CM II 5%.…”

Section: Discussionmentioning

confidence: 88%

Compositae sensitization in Danish children and adolescents

Paulsen

Andersen

2020

Contact Dermatitis

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Background Compositae plant sensitization in children is relatively frequent. From 1995–2006, we found a prevalence of 1.8% sesquiterpene lactone (SL) mix/parthenolide patch test positives among consecutive eczema patients <18 years. Objectives To report the results of patch test screening for Compositae sensitization in patients <18 years in the last 13 years. Methods Children and adolescents <18 years, diagnosed with Compositae sensitization between 2007 and 2019, were included. Results Among 388 children tested, 12 (3%) were Compositae‐sensitized, and 11 (2.8%) had positive reactions to SL mix. Compositae mix 5% pet. elicited positive reactions in six of seven patients tested, and dandelion extract 2.5% pet. in six of 10 patients tested. The mean age of the five girls and seven boys was 9.4 years and 11.7 years, respectively. Eleven children had a personal and one a family history of atopy, and 11 children had hand eczema. Only two were mono‐sensitized to Compositae. Conclusions SL mix is a suitable screening agent among children and adolescents in our area, well supplemented with Compositae mix 5% and dandelion extract. The study emphasizes the importance of Compositae screening in children with a personal and/or family history of atopy, hand eczema or widespread airborne dermatitis, summer exacerbation, and plant exposure.

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Screening for Compositae contact sensitization with sesquiterpene lactones and Compositae mix 2.5% pet

Cited by 20 publications

References 31 publications

Patch test results with the European baseline series and additions thereof in the ESSCA network, 2015‐2018

Patch test results with the European baseline series and additions thereof in the ESSCA network, 2015‐2018

Airborne allergic contact dermatitis caused by artichoke

Compositae sensitization in Danish children and adolescents

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