Screening for congenital hypothyroidism: results of screening 5600 Ardabil province infants

Mirzarahimi, Mehrdad; Barak, Manouchehr; Mardi, Afrouz; Enteshari-Moghaddam, Afsaneh

doi:10.18203/issn.2454-2156.intjscirep20174867

Cited by 3 publications

(2 citation statements)

References 20 publications

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“…13 There are some variations in different areas of Iran; for instance, in Tehran, Isfahan, Markazi province and Yazd (central cities of the country), the average prevalence rates of CH are reported at 1:914, 1:338, 1:307 and 1:1608 live births, respectively. 13,21,22 The incidence of CH in Ardabil was found to be 1:916, 23 whereas in the north of Iran, it was estimated at 1 per 491 live births. 24 Nevertheless, the prevalence of CH in Iran is higher than other countries.…”

Section: Discussionmentioning

confidence: 99%

Spatial Distribution of Congenital Hypothyroidism

et al. 2021

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Background: This study was designed and conducted to investigate the spatial distribution of permanent and temporary congenital hyperthyroidism (PCH and TCH) in Isfahan. Methods: This study was conducted on neonates who were born from March 21, 2006 to March 20, 2011 and had undergone the congenital hypothyroidism (CH) screening program in counties affiliated to the Isfahan University of Medical Sciences. CH was diagnosed in 958 patients who treated with levothyroxine. The incidence rates of permanent and temporary congenital hypothyroidism in Isfahan province were calculated and their distribution was shown on the map. The space maps were drawn using the ArcGIS software version 9.3. Results: Based on the data obtained from the screening program, the average incidence of congenital hypothyroidism in the province during the period of 2006–2011 was 2.40 infants per 1000 live births (including both PCH and TCH). The most common occurrence was in Ardestan County (10:1000) and the lowest overall incidence was observed in the Fereydounshahr county (1.39:1000). The incidence of PCH in the counties of Ardestan and Golpayegan had the highest rate in all years of study; and the greatest number of TCH cases in the five years were observed in Nain, Natanz, Khansar and Chadegan counties. Conclusion: Adding the time dimension and performing spatial-temporal analysis is suggested because of the following items: high prevalence of CH in Isfahan province, the important role of this disease in mental retardation and neuropsychiatric disorder, the necessity of conducting future medical researches to find possible factors of CH etiology in Isfahan province, as well as necessity of performing spatial analysis with advanced statistical methods.

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Section: Discussionmentioning

confidence: 99%

Spatial Distribution of Congenital Hypothyroidism

et al. 2021

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“…2 In the study conducted by Mirzarahimi and colleagues in Ardabil province on 160 babies, they showed that the prevalence of permanent hypothyroidism in Ardabil province was 1 in 4000. 3 Considering the complications of this disease and the importance of its timely diagnosis and treatment for babies up to 6 weeks old, screening for congenital thyroid disease is done from the heel and suspicious cases are diagnosed and treated. If the baby's TSH is above 20, hypothyroidism is considered and treated.…”

Section: Introductionmentioning

confidence: 99%

Relationship between infant hypothyroidism and maternal thyroid disease

Mirzarahimi,

Barak,

Katebi

et al. 2023

Int J Community Med Public Health

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Background: Due to the very high complications of neonatal hypothyroidism in the country, neonatal screening program is performed for timely diagnosis and treatment of neonates. The aim of this study to investigate the relationship between infant hypothyroidism and maternal thyroid disease. Methods: This cross-sectional study was done on 195 neonates with a diagnosis of hypothyroidism. Necessary data were collected by a checklist and then analyzed by statistical methods in statistical package for the social sciences (SPSS) version 21 by statistical methods. Results: Of all mothers, 21.0% had a history of thyroid disease. There was no statistically significant relationship between maternal age and infant thyroid stimulating hormone (TSH). There was no significant relationship between the history of maternal hypothyroidism and maternal hypothyroidism (during experiments) with the amount of TSH in the newborn. There was a direct and significant relationship between maternal TSH level and maternal free T4. But there was no statistically significant relationship between infant TSH level and maternal TSH level and free T4. There was no significant difference in neonatal TSH levels with maternal anti-TPO status. There was no significant relationship between the history of maternal diabetes and the history of maternal hypertension with neonatal TSH. There was no significant difference in neonatal TSH levels by maternal thyroid status. Conclusions: In the present study, no significant relationship was found between the incidence of neonatal hypothyroidism and the presence of thyroid disease in mothers. The existence of different genetic and environmental factors and the significant impact of each of these factors can justify this result.

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