Spatial Distribution of Congenital Hypothyroidism

Mahaki, Behzad; Mehrnejat, Neda; Zabihi, Mehdi; Dalvi, Marzie; Kazemitabaee, Maryamsadat

doi:10.34172/aim.2021.90

Cited by 4 publications

(3 citation statements)

References 34 publications

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“…This survey found that the female-to-male ratio of neonatal CH was 1.21 : 1, which is somewhat different from the female-to-male ratio of neonatal CH (3/4) reported in relevant literature [ 13 ], suggesting that the female-to-male ratio of neonatal CH varies in different regions, which may be due to different factors such as dietary habits, environment, and medical conditions in each region. Health education on neonatal CH in rural areas is not in place, especially for rural dwellers with low literacy levels and having poor knowledge about neonatal CH health and low understanding of relevant preventive measures, leading to an increased risk of CH [ 14 , 15 ]. This study showed that advanced maternal age was correlated with the occurrence of CH ( P < 0.05), and logistic regression analysis showed that advanced maternal age was one of the high risk factors for CH.…”

Section: Discussionmentioning

confidence: 99%

Serological Characteristics, Etiological Analysis, and Treatment Prognosis of Children with Congenital Hypothyroidism

shen¹,

Ding

2022

Emergency Medicine International

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Objective. The aim of the study is to analyze the serological features, etiology, and prognosis of congenital hypothyroidism (CH) treated with L-thyroxine sodium (L-T4). Methods. A total of 126 CH children in our hospital from June 2015 to January 2020 were selected as the research objects, and L-T4 treatment was given immediately after diagnosis. After diagnosis and 24 months of treatment, laboratory serum thyroid function-related indicators were examined, and thyroid changes were determined by ultrasound. We compared serum thyroxine levels in children with different thyroid changes, compared serum thyroid hormone levels, serum ghrelin levels, and body mass index (BMI) changes in children with CH before treatment and after 24 months of treatment, and analyzed the prognosis of treatment in children. In terms of thyroid changes in 126 CH children, 32 cases (25.40%) had a normal thyroid gland, 16 cases (12.70%) had a hypoplastic thyroid gland, 40 cases (31.75%) had an ectopic thyroid gland, 28 cases (22.22%) had an absent thyroid gland, and 10 cases (7.93%) had an enlarged thyroid gland, with an ectopic thyroid gland being the most common. In terms of serological expression of CH children, the TSH level in children with thyroid dysplasia was significantly higher than that in children with basic normal and T3 and T4 levels were significantly lower than those in children with basic normal ( P < 0.05 ). At the same time, the TSH level in children with thyroid absence, ectopic, and enlargement was increased, while thyroxine (T4) and tri-iodothyronine (T3) levels were decreased compared with those in children with thyroid dysplasia. The difference was statistically significant ( P < 0.05 ). Univariate analysis showed that there were statistically significant differences in birth weight, week of gestation at delivery, maternal age at childbirth, household registration, and a family history of thyroid disease compared between the two groups ( P < 0.05 ); multivariate logistic regression analysis showed that birth weight <2,500 g, maternal age >35 years, rural residence, and a family history of thyroid disease were risk factors for neonatal CH ( P < 0.05 ). Serum thyroid-stimulating hormone (TSH) levels, serum ghrelin levels, and the body mass index of children with CH decreased significantly, and T4 levels increased significantly after 24 months of treatment ( P < 0.05 ). Conclusion. Screening for common causes of CH is conducive to timely detection of children with CH, and L-T4 treatment can effectively improve thyroid function in children.

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Section: Discussionmentioning

confidence: 99%

Serological Characteristics, Etiological Analysis, and Treatment Prognosis of Children with Congenital Hypothyroidism

shen¹,

Ding

2022

Emergency Medicine International

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“…According to the authors, in the southern part concentration of iodine near the coast is high due to gas in the sea. And considering that people living near the beach, so for the southern part should consider a higher percentage than the 99 percentile (33,34). According to the spatial pattern obtained from of developments place -time incidence of CH in newborns Fars province, its spatial variation was not statistically signi cant.…”

Section: Methodsmentioning

confidence: 92%

Spatio-temporal pattern of congenital hypothyroidism screening success in Iran (Case study, Fars counties during 2005-2013)

Goli

Nematollahi

Razieh

et al. 2022

Preprint

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Objective: 1) Spatio-temporal analysis of CH screening success in Fars counties during 2005-2013; 2) To analyze Neonatal CH clusters in Fars counties during 2005-2013; and 4) Help to provide better planning budget and facilities for Disease Control of CH in the study area and other regions.Results: The results of this study showed that the incidence of disease duration was variable from 2 to 10 in every 1,000 newborn boys more than girls in the rate. Also, the spatial distribution pattern of CH in newborns in the period studied based on the statistical significance level (p-value) and the index of spatial autocorrelation (Moran 's I) had a random pattern. This result can identify factors involved in disease in order to better planning in the field budget and facilities needed for Disease Control and CH in the Fars province are very helpful. In different geographical areas of the province, the analysis of the spatial distribution of CH in newborns every year to show differences and show a uniformity pattern decrease and tend to focus on specific areas of space that may be the pattern (focus spatial) happen in the next few years.

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“…The disorder is divided into permanent and transient types; the transient type heals spontaneously, while the permanent type necessitates medication for the rest of life. The transient type is mainly caused by iodine disorders in the mother during pregnancy or exposure of the baby to high levels of iodine during or after birth (9). Thyroid hormones are necessary for the normal growth and development of the nervous system.…”

Section: Introductionmentioning

confidence: 99%

The incidence of congenital hypothyroidism in neonates born in Chaharmahal and Bakhtiari province from 2015 to 2021; A cross-sectional study

et al. 2022

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Introduction: Congenital hypothyroidism (CH) is one of the most common endocrine and metabolic disorders and a common preventable cause of mental retardation across the world. This disorder can be prevented if diagnosed and treated before the age of four weeks. Objectives: This study was performed to investigate the incidence rate of CH in infants in Chaharmahal and Bakhtiari province. Patients and Methods: The data of this study were obtained by the CH screening program from 2015 to 2021 in the health deputy of Chaharmahal and Bakhtiari province. Results: A total of 651 patients were diagnosed with CH, which showed an incidence rate of 5.06 per 1000 births (1 per 198 live births) in the province. The highest incidence of the disease was obtained in 2016 and the lowest incidence in 2021. Lordegan city had the highest incidence rate (8.1 per 1000 live births) and Kiar had the lowest one (1.67 per 1000 live births) during the study period. Moreover, the highest and lowest incidence rates in terms of season were observed in winter and summer, respectively. Conclusion: It can be concluded that Chaharmahal and Bakhtiari province, especially Lordegan, is one of the regions with high prevalence of CH in Iran, therefore the incidence rate is not only higher than the national average but also higher than the global average. Hence, the potential causes of this observation deserve further investigation.

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Spatial Distribution of Congenital Hypothyroidism

Cited by 4 publications

References 34 publications

Serological Characteristics, Etiological Analysis, and Treatment Prognosis of Children with Congenital Hypothyroidism

Serological Characteristics, Etiological Analysis, and Treatment Prognosis of Children with Congenital Hypothyroidism

Spatio-temporal pattern of congenital hypothyroidism screening success in Iran (Case study, Fars counties during 2005-2013)

The incidence of congenital hypothyroidism in neonates born in Chaharmahal and Bakhtiari province from 2015 to 2021; A cross-sectional study

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