Screening for hypertrophic cardiomyopathy in a young male military population

Nistri, Stefano; Thiene, Gaetano; Basso, Cristina; Corrado, Domenico; Vitolo, Antonio; Maron, Barry J.

doi:10.1016/s0002-9149(03)00132-2

Cited by 54 publications

(41 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…157 However, ECGs are a routine part of medical screening in candidates for aviation duty and in soldiers >40 years old. 158 From Italy, Nistri et al 159 reported on a military screening program from 1992 to 1996 that included history-taking, physical examination, and routine performance of a 12-lead ECG. Among 34 910 conscripts >17 years old, 8% had abnormalities that prompted further evaluation.…”

Section: Military Personnelmentioning

confidence: 99%

Assessment of the 12-Lead ECG as a Screening Test for Detection of Cardiovascular Disease in Healthy General Populations of Young People (12–25 Years of Age)

Maron¹,

Friedman²,

Kligfield³

et al. 2014

Circulation

248

152

View full text Add to dashboard Cite

Section: Military Personnelmentioning

confidence: 99%

Assessment of the 12-Lead ECG as a Screening Test for Detection of Cardiovascular Disease in Healthy General Populations of Young People (12–25 Years of Age)

Maron¹,

Friedman²,

Kligfield³

et al. 2014

Circulation

248

152

View full text Add to dashboard Cite

“…In the 11 primary studies 1,19,[23][24][25][26][27][28][29][30][31] that reported phenotypic (ECG-or ECHObased) prevalence findings, study populations ranged from general to subgroups of high school athletes and military conscripts. Studies were conducted in North America, Europe, and Asia and had sample sizes ranging from 1369 to 1 336 377 (Table 1).…”

Section: Characteristics Of Reviewed Studiesmentioning

confidence: 99%

“…Twenty primary studies 28,[32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50] reported sensitivity and specificity estimates by using ECG to detect LQTS and/or HCM,…”

Section: Characteristics Of Reviewed Studiesmentioning

confidence: 99%

“…Based on 7 studies, 1,19,24,25,[27][28][29] HCM phenotypic (ECG-or ECHO-based) prevalence ranged from 0 to 170 per 100 000 (Fig 2) with a summary phenotypic prevalence rate of 45 per 100 000 (95% CI: 10-79) but with substantial variation between studies (I 2 = 91%, P , .001). Inclusion of the study with a phenotypic prevalence estimate of zero 29 helped inform the upper bounds of the estimate.…”

Section: Hypertrophic Cardiomyopathymentioning

confidence: 99%

“…When adding 2 nonrepresentative studies 23,26 for sensitivity analysis, the summary phenotypic prevalence rate decreased to 13 per 100 000 (95% CI: 7-19) with substantial heterogeneity (I 2 = 92%, P , .001). Turning to screening for HCM, Fig 3 illustrates a set of HSROC curves for detection by ECG (10 studies), 28,[32][33][34][35][36][37][38][39][40] ECHO (6 studies), [33][34][35]37,40,41 and ECG/ ECHO (4 studies). [33][34][35]40 Based on the summary HSROC curves, the AUC values were high.…”

Section: Hypertrophic Cardiomyopathymentioning

confidence: 99%

See 2 more Smart Citations

Electrocardiogram Screening for Disorders That Cause Sudden Cardiac Death in Asymptomatic Children: A Meta-analysis

et al. 2012

View full text Add to dashboard Cite

BACKGROUND AND OBJECTIVES: Pediatric sudden cardiac death (SCD) occurs in an estimated 0.8 to 6.2 per 100 000 children annually. Screening for cardiac disorders causing SCD in asymptomatic children has public appeal because of its apparent potential to avert tragedy; however, performance of the electrocardiogram (ECG) as a screening tool is unknown. We estimated (1) phenotypic (ECG-or echocardiogram [ECHO]-based) prevalence of selected pediatric disorders associated with SCD, and (2) sensitivity, specificity, and predictive value of ECG, alone or with ECHO. METHODS:We systematically reviewed literature on hypertrophic cardiomyopathy (HCM), long QT syndrome (LQTS), and Wolff-ParkinsonWhite syndrome, the 3 most common disorders associated with SCD and detectable by ECG. RESULTS:We identified and screened 6954 abstracts, yielding 396 articles, and extracted data from 30. Summary phenotypic prevalences per 100 000 asymptomatic children were 45 (95% confidence interval [CI]: 10-79) for HCM, 7 (95% CI: 0-14) for LQTS, and 136 (95% CI: 55-218) for Wolff-Parkinson-White. The areas under the receiver operating characteristic curves for ECG were 0.91 for detecting HCM and 0.92 for LQTS. The negative predictive value of detecting either HCM or LQTS by using ECG was high; however, the positive predictive value varied by different sensitivity and specificity cut-points and the true prevalence of the conditions. CONCLUSIONS:Results provide an evidence base for evaluating pediatric screening for these disorders. ECG, alone or with ECHO, was a sensitive test for mass screening and negative predictive value was high, but positive predictive value and false-positive rates varied.

show abstract

Trends in Sudden Cardiovascular Death in Young Competitive Athletes After Implementation of a Preparticipation Screening Program

Corrado

Basso²,

Pavei³

et al. 2006

JAMA

1,335

1,064

View full text Add to dashboard Cite

The incidence of sudden cardiovascular death in young competitive athletes has substantially declined in the Veneto region of Italy since the introduction of a nationwide systematic screening. Mortality reduction was predominantly due to a lower incidence of sudden death from cardiomyopathies that paralleled the increasing identification of athletes with cardiomyopathies at preparticipation screening.

show abstract

Screening for hypertrophic cardiomyopathy in a young male military population

Cited by 54 publications

References 18 publications

Assessment of the 12-Lead ECG as a Screening Test for Detection of Cardiovascular Disease in Healthy General Populations of Young People (12–25 Years of Age)

Assessment of the 12-Lead ECG as a Screening Test for Detection of Cardiovascular Disease in Healthy General Populations of Young People (12–25 Years of Age)

Electrocardiogram Screening for Disorders That Cause Sudden Cardiac Death in Asymptomatic Children: A Meta-analysis

Trends in Sudden Cardiovascular Death in Young Competitive Athletes After Implementation of a Preparticipation Screening Program

Contact Info

Product

Resources

About