Screening for Pediatric Anxiety Disorders

Walkup, John T.; Green, Cori M.

doi:10.1001/jama.2022.15224

Cited by 6 publications

(5 citation statements)

References 14 publications

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“…Thus, it remains possible that, because of disease progression or later emergence of symptoms, additional developmental effects could accentuate or dampen the magnitude of the PBDE associations observed herein. Second, self‐report measures have inherent limitations (Walkup et al, 2022 ) and may differ from symptoms assessed by clinicians. Third, whether these symptoms represent psychiatric disorders (e.g., GAD, social anxiety disorder) cannot be determined in this sample as we did not include a clinician assessment.…”

Section: Discussionmentioning

confidence: 99%

“…Many psychological, biological and developmental risk factors increase the risk of developing anxiety (Strawn et al, 2021 ; Walkup et al, 2022 ). These include having an anxious parent (Beesdo et al, 2010 ), having specific personality disorder symptoms (Steinsbekk et al, 2019 ), family environment (Beesdo et al, 2010 ), early separation or institutionalization (Ellis et al, 2004 ) and specific attachment styles (Warren et al, 1997 ) and temperaments.…”

Section: Introductionmentioning

confidence: 99%

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Early exposure to flame retardants is prospectively associated with anxiety symptoms in adolescents: A prospective birth cohort study

Cecil

Altaye

et al. 2022

Depression and Anxiety

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Background Anxiety disorders emerge during childhood and adolescence and are frequently preceded by subsyndromal anxiety symptoms. Environmental toxicants, including gestational polybrominated diphenyl ether (PBDE) exposure, are associated with neuropsychiatric sequelae; however, the role of PBDEs as risk factors for anxiety in adolescence is unclear. Methods Using data from the Health Outcomes and Measures of the Environment (HOME) Study, a prospective pregnancy and birth cohort enrolled from 2003 to 2006, we investigated the relationship between gestational serum PBDE concentrations and anxiety symptoms in adolescents (N = 236). We measured five PBDE congeners (PBDE‐28, −47, −99, −100, and −153) at 16 ± 3 weeks of gestation and calculated their sum (∑PBDE). We assessed self‐reported anxiety symptoms using the Screen for Child Anxiety Related Emotional Disorders (SCARED) and depressive symptoms using the Children's Depression Inventory (CDI‐2) at age 12 years. We estimated the associations of maternal PBDE concentrations with child anxiety and depressive symptoms using multivariable linear regression and modified Poisson regression. Covariates included child sex, maternal race, maternal age at delivery, maternal marital status, maternal education, and household income at the 12‐year study visit as well as maternal depressive and anxiety symptoms. Sensitivity analyses were performed to control for maternal lead and mercury at delivery. Results After adjusting for predetermined covariates, each doubling in maternal PBDE concentrations was associated with increased SCARED scores (e.g., for ∑PBDE, SCARED total score, β = 1.6 95% confidence interval [CI]: 0.3–2.9, p = .019) and a nonsignificant increase in depressive symptoms (e.g., for CDI total score, β = .8, 95% CI: −0.2–1.8, p = .11). Conclusions Gestational serum PBDE concentrations just before mid‐pregnancy and during a period of active cortical and limbic neurogenesis, synaptogenesis and myelogenesis may be a risk factor for developing anxiety symptoms in early adolescence.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Early exposure to flame retardants is prospectively associated with anxiety symptoms in adolescents: A prospective birth cohort study

Cecil

Altaye

et al. 2022

Depression and Anxiety

Self Cite

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“…Anxiety disorders typically have onset early in life, hence the importance of screening for anxiety in children and adolescents when there is the opportunity to promptly intervene and prevent what can often be lifelong impairment . There are also 2 anxiety disorders that are encountered predominantly, though perhaps not exclusively, in pediatric settings: selective mutism and separation anxiety disorder .…”

mentioning

confidence: 99%

“…4 The latter 2 instances of anxiety are caused by identifiable and, mostly, treatable sources and should be considered "rule-outs" before concluding that one of the other anxiety disorders is present.Anxiety disorders typically have onset early in life, hence the importance of screening for anxiety in children and adolescents when there is the opportunity to promptly intervene and prevent what can often be lifelong impairment. 5 There are…”

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confidence: 99%

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Are There Reasons to Fear Anxiety Screening?

Stein

Hill

2023

JAMA

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Mental disorders are a leading cause of disease burden worldwide, with anxiety disorders being the second most influential contributor, after depressive disorders, to global disabilityadjusted life-years. 1 Anxiety disorders are characterized by anxious mood and, often, phobic avoidance, which result in extreme distress, functional impairment, or both. 2,3 The Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) (DSM-5) recognizes the following types of anxiety disorders likely to be seen in adults: generalized anxiety disorder, social anxiety disorder, panic disorder, agoraphobia, specific phobias, substance/ medication-induced anxiety disorder, and anxiety disorder due to another medical condition. 4 The latter 2 instances of anxiety are caused by identifiable and, mostly, treatable sources and should be considered "rule-outs" before concluding that one of the other anxiety disorders is present.Anxiety disorders typically have onset early in life, hence the importance of screening for anxiety in children and adolescents when there is the opportunity to promptly intervene and prevent what can often be lifelong impairment. 5 There are

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