Screening for potential novel probiotic Lactobacillus strains based on high dipeptidyl peptidase IV and α-glucosidase inhibitory activity

Zeng, Zhu; Luo, Junyi; Zuo, Fanglei; Zhang, Ying; Ma, Huiqin; Chen, Shangwu

doi:10.1016/j.jff.2015.11.030

Cited by 75 publications

(61 citation statements)

References 50 publications

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“…Probiotic also has been reported to have an anti-diabetic effect. Zeng et al (2016) reported that Lactobacilli probiotic has a potency to be anti-diabetic probiotics due to its ability to act as α-glucosidase inhibitor.…”

Section: Introductionmentioning

confidence: 99%

Anti-diabetic Potency and Characteristics of Probiotic Goat-Milk Yogurt Supplemented with Roselle Extract during Cold Storage

Wihansah

Arief

Batubara

2018

Trop. Anim. Sci. J.

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This study aimed to evaluate the anti-diabetic potency by in vitro method and the characteristics of probiotic goat-milk yogurt supplemented with roselle extract during cold storage. The experiment used three treatments namely yogurt, probiotic yogurt, and probiotic yogurt supplemented with roselle extract. Yogurt was stored in cold storage (4 o C) and was evaluated for the characteristics and anti-diabetic potency on days 0, 5, 10, and 15. The anti-diabetic potency was analyzed by a-glucosidase inhibitory activity. The results showed that goat milk in this study had a good quality including fat, SNF, protein, lactose content, density, and freezing point. Roselle extract had anti-diabetic potency with 87.72% inhibition at 25% concentration and also had 13.64% IC 50 value. The anti-diabetic potency was affected by the type of yogurt, storage duration, and their interaction (P<0.05). Viscosity and water activity were affected by storage duration (P<0.05), meanwhile titratable acidity and pH value were affected by the type of yogurt. Total lactic acid bacteria were affected by storage duration, and there was an interaction between the type of yogurt and storage duration. In conclusion, probiotic yogurt supplemented with roselle extract had the highest anti-diabetic potency among all treatments with 36.70% inhibition. The inhibitory activity of probiotic yogurt supplemented with roselle extract decreased during 15 days of cold storage. The inhibition was comparable with acarbose at 0.1-0.5 ppm concentration. Physical, chemical, and microbiological characteristics of yogurt in this study were good and could be consumed up to 15 days of cold storage.

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Section: Introductionmentioning

confidence: 99%

Anti-diabetic Potency and Characteristics of Probiotic Goat-Milk Yogurt Supplemented with Roselle Extract during Cold Storage

Wihansah

Arief

Batubara

2018

Trop. Anim. Sci. J.

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“…At same time, in Lactobacillus , trypsin treatment of bacterium‐secreted supernatant specifically elevated its DPP‐IV inhibitory activity, indicating that higher DPP‐IV inhibition might be attributable to generated peptides (Zeng et al . ). Therefore, we can speculate that the components responsible for DPP‐IV inhibition in Bifidobacterium are peptides; further investigation into these components’ identity is warranted.…”

Section: Resultsmentioning

confidence: 97%

Bifidobacteria possess inhibitory activity against dipeptidyl peptidase-IV

Zeng

Luo

Zuo

et al. 2016

Lett Appl Microbiol

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“…Aktivitas penghambatan terhadap enzim α-glukosidase menunjukkan perbedaan yang nyata antar isolat yang diujikan (P<0,01 Chen et al (2014a) terhadap beberapa strain BAL menunjukkan aktivitas yang lebih rendah (antara 3,42±0,14 sampai 29,57±1,38%) karena tidak diekstrak menggunakan pelarut organik, tetapi dilakukan pada supernatan bebas sel (SBS). Aktivitas penghambatan pada SBS lebih tinggi dibandingkan dengan komponen intraselulernya (Muganga et al, 2015;Zeng et al, 2016). Delapan strain Lactobacillus memiliki aktivitas penghambatan berkisar 18,7±0,2 sampai 28,3± 2,8% pada SBS, sedangkan komponen intraselulernya berkisar 0 sampai 13,7±0,8% (Zeng et al, 2016).…”

Section: Hasil Dan Pembahasan Aktivitas Bal Indigenus Dalam Menghambaunclassified

“…Aktivitas penghambatan pada SBS lebih tinggi dibandingkan dengan komponen intraselulernya (Muganga et al, 2015;Zeng et al, 2016). Delapan strain Lactobacillus memiliki aktivitas penghambatan berkisar 18,7±0,2 sampai 28,3± 2,8% pada SBS, sedangkan komponen intraselulernya berkisar 0 sampai 13,7±0,8% (Zeng et al, 2016).…”

Section: Hasil Dan Pembahasan Aktivitas Bal Indigenus Dalam Menghambaunclassified

“…Senyawa lain yang diduga berperan sebagai penghambat α-glukosidase adalah protein (Lacroix dan Li-Chan, 2013;Zeng et al, 2016). Aktivitas penghambatan α-glukosidase dari SBS beberapa Lactobacillus sp yang ditumbuhkan dalam media susu skim menunjukkan hasil yang bervariasi (5,3±0,7 sampai 32,9±1,0%) karena sifat proteolitik masingmasing isolat yang berbeda (Muganga et al, 2015).…”

Section: Hasil Dan Pembahasan Aktivitas Bal Indigenus Dalam Menghambaunclassified

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AKTIVITAS ANTIOKSIDAN DAN PENGHAMBATAN Α-Glukosidase OLEH EKSTRAK ETANOL BAKTERI ASAM LAKTAT INDIGENUS

Farida

Jenie

Nuraida

et al. 2019

jtip

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Lactic acid b acteria (LAB) are one of I ndonesia's b iodiversity which can b e b eneficial for food and health purposes. Some of LAB are potential prob iotics with specific functional properties, such as antidiab etes. This study evaluated the effect of ethanol extracts of twelve indigenous LAB in inhib iting αglucosidase enzyme and their antioxidant activities. Assay for the α-glucosidase inhib ition was performed on LAB ethanol extract using spectrophotometric method at λ=410 nm, while the antioxidant activity was measured using 1,1-diphenyl-2-picrylhydrazyl (DPPH) method at λ=517 nm. The results showed that αglucosidase inhib ition was significantly different b etween the isolates (P<0.01). Lactob acillus fermentum S21209 had the highest α-glucosidase inhib ition activity, which was significantly different from Lactob acillus plantarum MB427, Lactob acillus plantarum Pi28a, Lactob acillus delb rueckii W24802 and Lactob acillus plantarum 2 W22409. Evaluation of the antioxidant activity also showed significant difference b etween the isolates (P<0.01). Lactob acillus plantarum BSL had the highest antioxidant activity (92.81±1.36%), which was not significantly different from vitamin C as a control. This preliminary study reported that twelve indigenous LAB could b e used as potential antidiab etic prob iotics, although the responsib le compounds are not known.

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Screening for potential novel probiotic Lactobacillus strains based on high dipeptidyl peptidase IV and α-glucosidase inhibitory activity

Cited by 75 publications

References 50 publications

Anti-diabetic Potency and Characteristics of Probiotic Goat-Milk Yogurt Supplemented with Roselle Extract during Cold Storage

Anti-diabetic Potency and Characteristics of Probiotic Goat-Milk Yogurt Supplemented with Roselle Extract during Cold Storage

Bifidobacteria possess inhibitory activity against dipeptidyl peptidase-IV

AKTIVITAS ANTIOKSIDAN DAN PENGHAMBATAN Α-Glukosidase OLEH EKSTRAK ETANOL BAKTERI ASAM LAKTAT INDIGENUS

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