Screening Indian Plant Species for Antiplasmodial Properties – Ethnopharmacological Compared with Random Selection

Kantamreddi, Venkata Siva Satyanarayana; Wright, Colin W.

doi:10.1002/ptr.4651

Cited by 13 publications

(9 citation statements)

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“…In this study, the good level of antiplasmodial activity showed by the MeOH extract of E. scaber leaf (EC 50 = 0.27 μg/ml) was contradictory to the study reported by Kantamreddi and Wright [ 46 ]. According to Kantamreddi and Wright [ 46 ], the MeOH extract of the leaves of this plant was considered inactive (IC 50 = 133.8 μg/ml) against CQ resistant P. falciparum (K1) [ 46 ]. The possible reason for the contradictory results could be due to the differences in the duration of incubation in antiplasmodial assay.…”

Section: Discussioncontrasting

confidence: 94%

“…The present study has identified the antiplasmodial activity in selected plant extracts by HRP2-based assay or HRP2 ELISA technique. There are other reports on antiplasmodial studies using different screening methods such as WHO schizont maturation test [ 44 ], isotopic assay [ 45 ], pLDH enzymatic assay [ 46 , 47 ], SYBR Green I assay [ 48 – 50 ] or fluocytometric assay [ 51 ]. Briefly, the HRP2-based assay is a very sensitive and specific measures of P. falciparum growth by quantifying parasite specific biomolecule, HRP2.…”

Section: Discussionmentioning

confidence: 99%

“…In this study, A. galanga (rhizome), C. iners (leaf), C. zedoaria (rhizome), E. scaber (leaf), C. mangga (rhizome) and M. elliptica (leaf) were for the first time reported for their good level of antiplasmodial activities in vitro . Other potent antiplasmodial plants such as C. aeruginosa (rhizome) [ 62 ], V. negundo (leaf) [ 46 ], B. javanica (leaf and root) [ 45 , 51 , 62 ], A. muricata (leaf) [ 63 ] and V. amygdalina (leaf) [ 44 , 64 – 68 ] have been widely studied and were further discussed in this section.…”

Section: Discussionmentioning

confidence: 99%

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Effect of selected local medicinal plants on the asexual blood stage of chloroquine resistant Plasmodium falciparum

Razak

Afzan

Ali

et al. 2014

BMC Complement Altern Med

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BackgroundThe development of resistant to current antimalarial drugs is a major challenge in achieving malaria elimination status in many countries. Therefore there is a need for new antimalarial drugs. Medicinal plants have always been the major source for the search of new antimalarial drugs. The aim of this study was to screen selected Malaysian medicinal plants for their antiplasmodial properties.MethodsEach part of the plants were processed, defatted by hexane and sequentially extracted with dichloromethane, methanol and water. The antiplasmodial activities of 54 plant extracts from 14 species were determined by Plasmodium falciparum Histidine Rich Protein II ELISA technique. In order to determine the selectivity index (SI), all plant extracts demonstrating a good antiplasmodial activity were tested for their cytotoxicity activity against normal Madin-Darby Bovine Kidney (MDBK) cell lines by 3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay.ResultsTwenty three extracts derived from Curcuma zedoaria (rhizome), Curcuma aeruginosa (rhizome), Alpinia galanga (rhizome), Morinda elliptica (leaf), Curcuma mangga (rhizome), Elephantopus scaber (leaf), Vitex negundo (leaf), Brucea javanica (leaf, root and seed), Annona muricata (leaf), Cinnamomun iners (leaf) and Vernonia amygdalina (leaf) showed promising antiplasmodial activities against the blood stage chloroquine resistant P. falciparum (EC50 < 10 μg/ml) with negligible toxicity effect to MDBK cells in vitro (SI ≥10).ConclusionThe extracts belonging to eleven plant species were able to perturb the growth of chloroquine resistant P. falciparum effectively. The findings justified the bioassay guided fractionation on these plants for the search of potent antimalarial compounds or formulation of standardized extracts which may enhance the antimalarial effect in vitro and in vivo.

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Section: Discussioncontrasting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Effect of selected local medicinal plants on the asexual blood stage of chloroquine resistant Plasmodium falciparum

Razak

Afzan

Ali

et al. 2014

BMC Complement Altern Med

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“…About 80% of the world population still primarily rely on herbal drugs. 1 In India, Ayurvedic medicines were widely considered due to affordability and availability in local markets. Also, the demand for Ayurveda drugs in Western market has increased tremendously which draw attention to the need of quality of Ayurvedic products.…”

Section: Introductionmentioning

confidence: 99%

A Quantitative Approach to Estimate both Essential and Non-essential Elements in Some Commercial Samples of Triphala churna by using WD-XRF Spectrometry

Kantamreddi¹,

Veni²,

Swamy³

2017

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Introduction: The need for quality control of herbal drugs is in demand in order to ensure the purity, safety and efficacy of herbal products. A total of 19 elements including essential and non-essential elements were characterized in five commercial samples of Triphala churna using WD-XRF spectrometry. Method: The WD-XRF method was validated for each element by a pre-calibrated program using five Chinese certified reference materials of vegetable standards (NCS ZC73012, NCS ZC73013, NCS ZC73017, NCS ZC85006 and NCS DC73348). Results: The following elements were detected in all the samples out of 19 elements tested with increasing order of concentrations (mg/kg): Cr (3) < Cu (7) < Ba (24) < Zn (31) < Pb (46) < Mn (57) < S (700) < Na (1064) < Mg (1250) < Fe (1329) < P (1400) < Cl (2960) < Ca (3110) < Si (4350) < K (15130). Lead (41-46 mg/kg), a nonessential element was found above its PDE limit (≤ 10 mg/kg). Conclusion: WD-XRF method was found simple, rapid, reliable and non-destructive technique to investigate the elemental concentrations in herbal drugs.

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“…1 Herbal drugs are gaining popularity worldwide, and there are many branded and unbranded formulations are available for therapeutic and cosmetic uses. 2,3 But, the cases of adverse health consequences caused by the use of herbal medicines have also been increasing simultaneously.…”

Section: Introductionmentioning

confidence: 99%

Differentiation of Five Commercially Available Triphala churnas of an Ayurvedic Formulation by Elemental Fingerprint

Kantamreddi¹,

Veni²,

Simhachalam³

2016

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Introduction: Triphala churna (TPC) is one of the well known Ayurvedic powdered preparations of Indian System of Medicine and is used in the treatment of various diseases. Elemental pattern of TPC was developed in order to investigate the identity and quality of commercial TPC drugs. Method: Inductively coupled plasma mass spectrometry (ICP-MS) was used for the quantitative determination of ten essential and trace elements in five marketed samples of Triphala churna. The concentration patterns of these elements were deciphered by multivariate statistical analysis such as hierarchical cluster analysis (HCA), fuzzy c-means (FCM) and k-means (KM) cluster analysis. Results: The elemental concentrations ranged from 1.3 mg/kg (Cr, TPC3) to 14220 mg/kg (K, TPC4). The elemental fingerprint of Triphala churna was established based on three churnas viz. TPC1, TPC3 and TPC5, which were found in one cluster with a very high degree of similarity by KM, FCM and HCA techniques. Conclusion: Based on the results, the graphical pattern of elements detected in these samples can be considered as elemental fingerprint of Triphala churna and can be used for authentication and/or to determine the quality of commercial TPC drugs.

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Screening Indian Plant Species for Antiplasmodial Properties – Ethnopharmacological Compared with Random Selection

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Cited by 13 publications

References 32 publications

Effect of selected local medicinal plants on the asexual blood stage of chloroquine resistant Plasmodium falciparum

Effect of selected local medicinal plants on the asexual blood stage of chloroquine resistant Plasmodium falciparum

A Quantitative Approach to Estimate both Essential and Non-essential Elements in Some Commercial Samples of Triphala churna by using WD-XRF Spectrometry

Differentiation of Five Commercially Available Triphala churnas of an Ayurvedic Formulation by Elemental Fingerprint

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