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Despite decades of intense research, malaria remains a deadly disease worldwide and new antimalarials are urgently needed due to increasing drug resistance of Plasmodium falciparum to existing drugs. This article reports the evaluation of four Indian Diospyros species viz., Diospyros melanoxylon, D. peregrina, D. sylvatica, D. tomentosa for antiplasmodial activities against chloroquine-sensitive (3D7) and chloroquine-resistant (K1) strains of P. falciparum. Six of eight methanolic extracts were found to have significant activity, (IC50 = 16.5–92.9 µg ml−1), against strain 3D7 and five of these showed similar activities against strain K1 (IC50 = 20.5–121.6 µg ml−1). Diospyros sylvatica was found to be the most active species (IC50 = 16.5–29.4 µg ml−1) and is worthy of further investigation.

The potential of mass spectrometry (MS) is often not fully utilized due to the absence of systematic workflow of mass spectral interpretation, partially caused by the lack of simplified literature for interpretation of soft ionization methods and collision induced fragmentation spectral data interpretation. Therefore, this review summarizes the rational work flows for the interpretation of mass spectral data generated using atmospheric pressure ionization (API) and collision induced dissociation (CID) fragmentation. Designed workflow will definitely assist the readers to interpret MS and MS/MS spectral data, especially for the structural elucidation of small drug molecules and their impurities.

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