Screening of 25 compounds isolated from <i>Phyllanthus</i> species for anti‐human hepatitis B virus <i>in vitro</i>

Huang, Ray Ling; Huang, Yü; Ou, Jun; Chen, Chien Chih; Hsu, Feng Lin; Chang, Chung-Ming

doi:10.1002/ptr.1167

Cited by 110 publications

(73 citation statements)

References 15 publications

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“…Phyltetralin, nirtetralin and niranthin exhibited anti-inflammatory activity by inhibiting carrageenan-induced paw oedema and neutrophil influx (Kassuya et al 2005). Huang et al (2003) reported the anti-HBsAg and anti-HBeAg activities of niranthin and nirtetralin and the compounds suppressed HBsAg and HBeAg expression effectively at a non-cytotoxic concentration of 50 mM.…”

Section: Lignansmentioning

confidence: 99%

Phytochemicals from Phyllanthus niruri Linn. and their pharmacological properties: a review

Bagalkotkar

Sagineedu

Saad

et al. 2006

Journal of Pharmacy and Pharmacology

241

154

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This review discusses the medicinal plant Phyllanthus niruri Linn. (Euphorbiaceae), its wide variety of phytochemicals and their pharmacological properties. The active phytochemicals, flavonoids, alkaloids, terpenoids, lignans, polyphenols, tannins, coumarins and saponins, have been identified from various parts of P. niruri. Extracts of this herb have been proven to have therapeutic effects in many clinical studies. Some of the most intriguing therapeutic properties include anti-hepatotoxic, anti-lithic, anti-hypertensive, anti-HIV and anti-hepatitis B. Therefore, studies relating to chemical characteristics and structural properties of the bioactive phytochemicals found in P. niruri are very useful for further research on this plant as many of the phytochemicals have shown preclinical therapeutic efficacies for a wide range of human diseases, including HIV/ AIDS and hepatitis B.

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Section: Lignansmentioning

confidence: 99%

Phytochemicals from Phyllanthus niruri Linn. and their pharmacological properties: a review

Bagalkotkar

Sagineedu

Saad

et al. 2006

Journal of Pharmacy and Pharmacology

241

154

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“…Thus, the application of light qualities in tissue cultures could be a useful strategy for improving therapeutic metabolites under standardized conditions, and it is certainly useful in plantlet production. In our study, we showed that yellow light stimulated the production of phenolic compounds that are the main therapeutic constituents of P. tenellus, including tannins and flavonoids (Huang et al, 2003), suggesting that yellow light plays an important role in the biosynthesis of phenolic compounds in P. tenellus. The use of HPLC coupled to a diode array detector revealed a higher amount of phenolic compounds in crude aqueous extracts.…”

Section: Discussionmentioning

confidence: 56%

“…In particular, this species, also known as quebra-pedra or ervapombinha, is used in folk medicine to treat kidney disease, urinary bladder disturbances and hepatitis (Lorenzi and Matos, 2008). The therapeutic value of P. tenellus arises from its phenolic compounds, including tannins and flavonoids (Huang et al, 2003). Environmental, physical and biotic factors all interact to affect plant development, resulting in morpho-anatomical and physiological phenotypic plasticity (Catoni et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Light spectra affect the morphoanatomical and chemical features of clonal Phyllanthus tenellus Roxb. grown in vitro

Cristiane¹,

Marcos²,

Eliana³

et al. 2015

J. Med. Plants Res.

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Phyllanthus tenellus Roxb. is a widely distributed tropical medicinal plant and highly valued for its therapeutic properties. Since variable light conditions can significantly alter phenolic compounds that are the main therapeutic constituents of P. tenellus, including tannins and flavonoids, the development of this plant and its chemical metabolism in response to different light spectra were investigated. To accomplish this, P. tenellus was cultured in modified Murashige and Skoog (MS) medium for 60 days, and its development, leaf anatomy and phytochemistry were analyzed after exposure to white, red, green, yellow and blue light, as well as darkness. Compared to white light, the best in vitro morphogenic responses, including rooting percentage, shoot height, number of leaves, and number and length of branches, occurred under exposure to blue and yellow light. Plantlets developed under white and blue lights presented the greatest thickness of palisade and spongy parenchymas. Under dark condition, plantlets showed fragile aspect and the lowest thickness of leaf tissues. In contrast to other light treatments, chlorophyll and carotenoid contents were significantly lower in plants maintained under green light, whereas yellow light improved the production of phenolic compounds. These results highlight the influence of different light spectra on morphoanatomical features and suggest how different light spectra affect secondary metabolite production in the context of preserving this plant's therapeutic integrity.

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“…It has been reported to exhibit marked anti-hepatitis B virus surface antigen activity both in in vivo [1][2][3] and in vitro studies [4,5]. Furthermore, the plant has been reported to possess antibacterial [6], anticrustacean [7], antiviral [8], anti-inflammatory [9], anticancerous [10], antidiabetic, and anticholesterol activities [11]. Different parts of plant are ethnobotanically reported to have various therapeutic activities such as expectorant, diaphoretic, and diuretic [12].…”

Section: Introductionmentioning

confidence: 99%

HPLC analysis ofPhyllanthus amarussamples stored in stability chambers under different conditions and study of the effect on quantification of the phytomarkers phyllanthin and hypophyllanthin

Srivastava¹,

Raut²,

Puntambekar³

et al. 2015

Acta Chromatographica

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Summary. Storage of medicinal plants may cause deterioration of the active principles with time, thus, reducing the efficacy of plants. Therefore, quantification of the active principle is essential before using the crude drug. Phyllanthus amarus (PA) contains lignans, namely, phyllanthin and hypophyllanthin, which shows anti-hepatotoxic activity. In this paper, we highlight the effect of storage conditions on the quantification of bioactive markers by high-performance liquid chromatography (HPLC) analysis in the crude plant material of PA. HPLC analysis of crude PA samples stored for certain period at long-term study (LS, 30 °C and 65% RH), accelerated study (AS, 40°C and 75% RH), and real-time study (RT) conditions was carried out using the LiChroCART Purospher® STAR RP-18 endcapped (250 × 4.6 mm, 5 μm) column along with a Purospher STAR RP 18e (4.0 × 4.0 mm, 5 μm) guard column using methanol:water (70:30) at a flow rate of 0.7 mL min −1 with ultraviolet (UV) detection at 220 nm. The HPLC study indicated that PA samples kept under LS condition are rich in lignan contents as compared to the samples stored under AS and RT study conditions. Therefore, PA should be used fresh to get maximum concentration of active lignans or it should be stored under LS conditions up to 6 months.

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Screening of 25 compounds isolated from Phyllanthus species for anti‐human hepatitis B virus in vitro

Cited by 110 publications

References 15 publications

Phytochemicals from Phyllanthus niruri Linn. and their pharmacological properties: a review

Phytochemicals from Phyllanthus niruri Linn. and their pharmacological properties: a review

Light spectra affect the morphoanatomical and chemical features of clonal Phyllanthus tenellus Roxb. grown in vitro

HPLC analysis ofPhyllanthus amarussamples stored in stability chambers under different conditions and study of the effect on quantification of the phytomarkers phyllanthin and hypophyllanthin

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